Treatment of Peyronie’s Disease With Potassium Para-Aminobenzoate (potaba)

Treatment of Peyronie's disease with oral colchicine: long‐term results and predictive parameters of successful outcome

“…18 Potaba was introduced into the treatment regimen for Peyronie's disease in 1959 by Zarafonetis and Horrax. 18,29 In a recent report by Carson, treatment with Potaba resulted in improvement in penile angulation in 58% and complete resolution of angulation 25.8%, but had several disadvantages such as its high cost and severe gastrointestinal side effects. 30 Tamoxifen has also been reported to improve the deformity in more than 30% cases but facial¯ushing, reduced libido and ejaculate volume are some of its side effects.…”

Pathophysiology of Peyronie's disease

“…As described briefly earlier, it has been hypothesized that oxidative damage may be causal in the initiation and progression of tissue fibrosis. 36 While there is limited reported efficacy and no double blinded trials, both para-aminobenzoic acid 37 and vitamin E 38 have been reported as a treatment of Peyronie's disease. Intraplaque injection of the anti-inflammatory protein orgotein 39 -42 which has superoxide dismutase activity or bovine superoxide dismutase 43 are reported to improve symptoms in Peyronie's patients, although adequate clinical trials are lacking.…”

Management of Peyronie's disease with penile prostheses

“…Vitamin E, 2 Potaba, 3 colchicine, 4 as well as a number of other medications have been tried and despite initial glowing reports success has not been substantiated with time. These medications have been designed to reduce the inflammatory response and unfortunately by the time the patient presents for treatment inflammation and scar formation are well underway or possibly even complete.…”