Treatment of plantar erosive lichen planus with topical cyclosporin

Paçô, M; Silva, Rafael Arcanjo Duarte e

doi:10.1046/j.1468-3083.2001.00129-3.x

Cited by 14 publications

(5 citation statements)

References 8 publications

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“…Topical ciclosporin suspension (5 mL of 100 mg/mL swished and expectorated after 5 min) has been used to treat oral erosive lichen planus (52). Similarly plantar erosive lichen planus has also been shown to respond to topical ciclosporin (53). No systemic side effects were noted with topical ciclosporin.…”

Section: Lichen Planusmentioning

confidence: 99%

Systemic ciclosporin and tacrolimus in dermatology

Madan

Griffiths

2007

Dermatol Ther

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Ciclosporin and tacrolimus are calcineurin inhibiting immunosuppressant agents useful in the treatment of immune-mediated inflammatory dermatoses. Available data and clinical experience demonstrate ciclosporin's efficacy in treating psoriasis, atopic dermatitis, pyoderma gangrenosum, lichen planus, autoimmune bullous disease (in combination with corticosteroids), recalcitrant chronic idiopathic urticaria, and chronic dermatitis of the hands and feet. Although the role of topical tacrolimus in atopic dermatitis is well established, such experience with the oral formulation of tacrolimus has been limited. However, there are several case studies and anecdotal reports of the successful use of oral tacrolimus in various dermatoses. In this article we discuss the utility of systemic ciclosporin and tacrolimus in dermatology.

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Section: Lichen Planusmentioning

confidence: 99%

Systemic ciclosporin and tacrolimus in dermatology

Madan

Griffiths

2007

Dermatol Ther

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“…There was no detectable cyclosporine level in blood during treatment, which probably depended both on the concentration of the solution used and the surface of application [26]. Paçi and Silva reported a case of an 81-year-old female with just ulcerative LP on the sole of her right foot, without any other lesions.…”

Section: Resultsmentioning

confidence: 99%

“…The treatment was continued twice a week for 10 months with a considerable improvement. During the treatment cyclosporine was never detected in blood tests and the authors did not notice any undesirable secondary effects [26]. …”

Section: Resultsmentioning

confidence: 99%

Treatment modalities of palmoplantar lichen planus: a brief review

Feily¹,

Yaghoobi²,

Nilforoushzadeh³

2016

pdia

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Palmoplantar lichen planus is a localized and uncommon variant of lichen planus which is mostly resistant to treatment. Our purpose was to discuss all treatment modalities proposed and tested for palmoplantar lichen planus in the literature. A systematic review of the literature was conducted to evaluate evidence regarding all treatment modalities proposed and tested for palmoplantar lichen planus in the literature. Two major databases (PubMed, Google scholar) were searched. The review included all case reports, letters and original articles reporting any treatment for palmoplantar lichen planus but not treatment used in the other type of lichen planus, generalized lichen planus or other type of palmoplantar dermatoses. We have gone over more than 50 articles. There are many drugs that have been used in the treatment of lichen planus and generalized lichen planus but the palmoplantar type is a rare variety of lichen planus. That is why we could not find any clinical trial on the subject and just case reports have been described in this manuscript. In spite of plentiful investigations carried out on lichen planus, there is no treatment modality that has proved to be utterly satisfactory in treatment of palmoplantar lichen planus.

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“…De Jong and Van De Kerkhof (7) reported remission with acitretin therapy in a patient with palmoplantar lichen planus/lupus erythematosus overlap syndrome who was unresponsive to corticosteroids. Another resistant case with erosive plantar lichen planus unresponsive to steroids, retinoids, and thalidomide was successfully treated with topical cyclosporin (8). Surgical treatment with excision and grafting has also been suggested in painful erosive cases resistant to all modalities (12).…”

Section: Discussionmentioning

confidence: 99%

Palmoplantar Lichen Planus Presenting with Vesicle‐Like Papules

Gündüz

İnanır

Türkdoğan

et al. 2003

The Journal of Dermatology

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Palmoplantar lichen planus is a rare, localized variant of the disease that may create difficulty in diagnosis if it is present as an isolated finding. Although several morphological patterns may be seen, plaques or small papules with compact hyperkeratosis are usually observed. We present a 25-year-old woman with a one-month history of slightly pruritic, red papules on her palms and soles. Dermatologic examination revealed numerous, asymptomatic, unscaly, red papules on her palms and soles, some of them resembling vesicles and white reticulate plaques on both sides of the buccal mucosa. The diagnosis was established by the typical histopathological features of lichen planus. Although resistant to topical corticosteroids, she responded well to systemic corticosteroid therapy, and no recurrence was observed during the follow-up period of one year.

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Treatment of plantar erosive lichen planus with topical cyclosporin

Cited by 14 publications

References 8 publications

Systemic ciclosporin and tacrolimus in dermatology

Systemic ciclosporin and tacrolimus in dermatology

Treatment modalities of palmoplantar lichen planus: a brief review

Palmoplantar Lichen Planus Presenting with Vesicle‐Like Papules

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