Treatment of Posttraumatic Stress Disorder Using the Traditional Japanese Herbal Medicine Saikokeishikankyoto: A Randomized, Observer‐Blinded, Controlled Trial in Survivors of the Great East Japan Earthquake and Tsunami

Numata, Tomohiro; GunFan, Shen; Takayama, Shin; Takahashi, Satoshi; Monma, Yuto; Kaneko, S.; Kuroda, Hiroshi; Tanaka, Junichi; Kanemura, Seiki; Nara, Masayuki; Kagaya, Yutaka; Ishii, Tadashi; Yaegashi, Nobuo; Kohzuki, Masahiro; Iwasaki, Katsunori

doi:10.1155/2014/683293

Cited by 21 publications

(20 citation statements)

References 13 publications

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“…These patients have received either a herbal treatment, saikokeishikankyoto (SKK), or placebo for two weeks. This study demonstrated the efficacy of SKK-phytotherapy to reduce PTSD symptoms [41].…”

Section: Discussionmentioning

confidence: 58%

Double-blind, Randomized, Placebo-Controlled study to evaluate the Efficacy of an early treatment with Herbal Supplement based in the Prevention of Post-Traumatic Stress Disorder in emergency department (PHYTéS Study)

Boukef

Youssef

Yaacoubi

et al. 2022

Preprint

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Introduction: The prevention from Post-traumatic stress disorder (PTSD) is therefore of major public health interest and one of the concerns of any emergency physician. The purpose of our study was to evaluate the efficacy and safety of an herbal supplement to prevent the occurrence of PTSD in high-risk patients. Methods: It is a randomized, double-blind, prospective, interventional study including patients exposed to a potentially traumatic event that meets DSM-V Criterion A and has a Peri-traumatic Distress Inventory score or the Questionnary for traumatic dissociation experiments (PDEQ) and/or L.Crocq score higher than the thresholds between day 1 and day 3. Two hundred patients were included randomly assigned into two groups: Aleozen group and placebo group. Patients included in aleozen group received Aleozen® for 10 days while patients in placebo group received Placebo. A CAPS-5 assessment was performed for all patients at different moments. The main objective was to assess the efficacy of Aleozen after 90 days of an exposition to traumatic events according to PTSD. Secondary objectives were to evaluate the safety of Aleozen® at 10 and 30 days after its administration and PTSD in the study population after one year of inclusion. Results: No statistical differences were noted between the two groups in term of baseline characteristics including age, sex and the ISS score. After 90 days of follow-up, and according to the CAPS-5 scale, 85 patients (42.5%) of the population study showed PTSD. Concerning primary endpoint, less PTSD were seen in intervention group compared to placebo group (38.8% versus 61.2% respectively; p<0.001). During the study, no adverse events were noted. Conclusion: Results of this work suggest the potential preventive effects of an herbal supplement on PTSD for traumatic patient in emergency. Further confirmatory studies are needed.

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Section: Discussionmentioning

confidence: 58%

Double-blind, Randomized, Placebo-Controlled study to evaluate the Efficacy of an early treatment with Herbal Supplement based in the Prevention of Post-Traumatic Stress Disorder in emergency department (PHYTéS Study)

Boukef

Youssef

Yaacoubi

et al. 2022

Preprint

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“…These herbs improved somatization, compulsive behavior, depression, anxiety, hostility and sleep quality without serious side effects, which indicated that Xiaotan Jieyu Recipe is a safe and effective option to improve the poor mental state of PTSD patients. (36) Numata, et al (37) reported that after the Great Eastern Japan earthquake and Tsunami, Kampo used Japanese traditional herbal medicine (Saikokokeishikankyoto, SKK) to treat PTSD. The effi cacy of this therapy was studied in a randomized controlled trial (RCT), and the results showed that SKK significantly improved modified event scale score.…”

Section: Clinical Applications Of Herb Medicine In Ptsdmentioning

confidence: 99%

Advances in Treatment of Post-Traumatic Stress Disorder with Chinese Medicine

Wang

2021

Chin. J. Integr. Med.

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“Timely, near, and expectation” is the main principle of battlefield rescue for military combat stress reaction (CSR). Post-traumatic stress disorder (PTSD) is the most common form of CSR and a long-term persistent mental disorder that is caused by unusual threatening or catastrophic psychological trauma. Chinese medicine (CM) has abundant resources, is simple, easy to master, with few side effects. This article summarizes the cellular and animal experimental mechanisms of CM treatment on PTSD, suggesting that traditional Chinese herbs and acupuncture can protect brain functional areas, and adjust hypothalamus-pituitary-adrenal axis. Traditional Chinese herbs and acupuncture have shown good anti-stress efficacy and fewer side effects in clinical application, which may improve the CSR in the battlefield.

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“…Rikkosan, a negative regulator of IL-1β network [14], plays a supplementary role for stomatitis by relieving the pain. Kamishoyosan (KSS), that enhances peripheral circulation and reduces stress and associated pain [15], and saikokeishikankyoto, that reduces posttraumatic stress [16], are effective to refractory and recurrent stomatitis.…”

Section: Data Search For Traditional Medicine For the Treatment Ofmentioning

confidence: 99%

Search for Drugs Used in Hospitals to Treat Stomatitis

et al. 2019

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Stomatitis is an inflammatory disease of the oral mucosa, often accompanied by pain. Usually it is represented by aphthous stomatitis, for which treatment steroid ointment is commonly used. However, in the cases of refractory or recurrent stomatitis, traditional herbal medicines have been used with favorable therapeutic effects. Chemotherapy, especially in the head and neck region, induces stomatitis at higher frequency, which directly affects the patient’s quality of life and treatment schedule. However, effective treatment for stomatitis has yet to be established. This article presents the clinical report of Kampo medicines on the stomatitis patients in the Nihon university, and then reviews the literature of traditional medicines for the treatment of stomatitis. Among eighteen Kampo medicines, Hangeshashinto has been the most popular for the treatment of stomatitis, due to its prominent anti-inflammatory activity. It was unexpected that clinical data of Hangeshashinto on stomatitis from Chinese hospital are not available. Kampo medicines have been most exclusively administered to elder person, as compared to pediatric population. Supplementation of alkaline plant extracts rich in lignin-carbohydrate complex may further extend the applicability of Kampo medicines to viral diseases.

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Treatment of Posttraumatic Stress Disorder Using the Traditional Japanese Herbal Medicine Saikokeishikankyoto: A Randomized, Observer‐Blinded, Controlled Trial in Survivors of the Great East Japan Earthquake and Tsunami

Cited by 21 publications

References 13 publications

Double-blind, Randomized, Placebo-Controlled study to evaluate the Efficacy of an early treatment with Herbal Supplement based in the Prevention of Post-Traumatic Stress Disorder in emergency department (PHYTéS Study)

Double-blind, Randomized, Placebo-Controlled study to evaluate the Efficacy of an early treatment with Herbal Supplement based in the Prevention of Post-Traumatic Stress Disorder in emergency department (PHYTéS Study)

Advances in Treatment of Post-Traumatic Stress Disorder with Chinese Medicine

Search for Drugs Used in Hospitals to Treat Stomatitis

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