2009
DOI: 10.1111/j.1463-5224.2008.00679.x
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Treatment of proliferative feline eosinophilic keratitis with topical 1.5% cyclosporine: 35 cases

Abstract: Objective Proliferative feline eosinophilic keratitis is a chronic keratopathy caused by a suspected immune mediated response to an unknown antigenic stimulus. The purpose of this study is to demonstrate the efficacy of topical 1.5% cyclosporine solution in proliferative feline eosinophilic keratitis. Methods Thirty-five cats were treated topically with 1.5% cyclosporine A between 1997 and 2007. Eosinophilic keratitis was diagnosed by clinical appearance and evidence of eosinophils and/or mast cells in corneal… Show more

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Cited by 47 publications
(109 citation statements)
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“…The proportion of cats with concomitant corneal ulcers (33.3%) was similar to that reported in two previous studies -28.6%3 and 24%4 -higher than that reported by Paulsen (13%). 5 Much of the data reported here are consistent with published results: [3][4][5]8 age at diagnosis (median, 4-6 years), 3,4 position on the cornea, involvement mostly unilateral. The right and left eyes were affected with equal frequency in this study.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…The proportion of cats with concomitant corneal ulcers (33.3%) was similar to that reported in two previous studies -28.6%3 and 24%4 -higher than that reported by Paulsen (13%). 5 Much of the data reported here are consistent with published results: [3][4][5]8 age at diagnosis (median, 4-6 years), 3,4 position on the cornea, involvement mostly unilateral. The right and left eyes were affected with equal frequency in this study.…”
Section: Discussionsupporting
confidence: 91%
“…8 More recent studies have proposed an alternative to corticosteroid treatment. 3 In the current study, we based our investigation of the disease by retrospectively selecting cases based on their clinical presentation. We gathered data available on each Feline eosinophilic keratoconjunctivitis: a retrospective study of 45 cases (56 eyes)…”
Section: Introductionmentioning
confidence: 99%
“…Regardless of the clinical presentation, cytologic evaluation identifies eosinophils when examined microscopically. Eosinophilic keratitis has been reported in horses, 3, 4, 5, 6, 7, 8, 9, 10, cats 11, 12, 13, 14, 15, 16, and rabbits 17.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, corticosteroids are often contraindicated when FHV-1 infection is suspected. 22 It is possible that tacrolimus or cyclosporine could be effective as sole therapies rather than as an adjunct to surgical excision for feline epitheliotropic mastocytic conjunctivitis; however, further data would be needed to evaluate medical management alone. Nonetheless, a diagnostic biopsy is necessary in order to differentiate this condition from neoplasia.…”
Section: Discussionmentioning
confidence: 99%
“…The wide array of treatments prescribed makes it difficult to comment upon preferred protocols; however, recurrences in 2 cats were reasonably controlled with long-term topical therapy with tacrolimus or corticosteroid. Immunomodulating therapy (eg, cyclosporine, tacrolimus) is also an effective way of managing human vernal conjunctivitis 8,11 and proliferative or eosinophilic keratitis in cats 22 and is typically not associated with the adverse effects seen with long-term topical treatment with corticosteroids. Moreover, corticosteroids are often contraindicated when FHV-1 infection is suspected.…”
Section: Discussionmentioning
confidence: 99%