Treatment of Psoriasis: Novel Approaches to Topical Delivery

Wollina, Uwe; Tirant, Michael; Vojvodić, Aleksandra; Lotti, Torello

doi:10.3889/oamjms.2019.414

Cited by 23 publications

(14 citation statements)

References 51 publications

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“…The second route, transappendageal, involves the passage of agents through the hair follicles and through the sweat glands [15]. Thus, topical application may result in the release of the drug into the skin and into the systemic circulation through percutaneous absorption including the passage of topically-applied molecules to the skin, percutaneous penetration during which the compounds move from the surface of the stratum corneum through the skin to the systemic circulation, and the permeation of chemical compounds through the skin by diffusion or through the pores [16].…”

Section: Introductionmentioning

confidence: 99%

Hydrogel-Based Active Substance Release Systems for Cosmetology and Dermatology Application: A Review

Zagórska‐Dziok

Sobczak

2020

Pharmaceutics

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Hydrogels are playing an increasingly important role in medicine and pharmacy. Due to their favorable physicochemical properties, biocompatibility, and designed interaction with living surroundings, they seem to be one of the most promising groups of biomaterials. Hydrogel formulations from natural, semi, or synthetic polymeric materials have gained great attention in recent years for treating various dermatology maladies and for cosmetology procedures. The purpose of this review is to present a brief review on the basic concept of hydrogels, synthesis methods, relevant mechanisms, and applications in dermatology or cosmetology. This review discusses transdermal therapies and the recent advances that have occurred in the field.

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Section: Introductionmentioning

confidence: 99%

Hydrogel-Based Active Substance Release Systems for Cosmetology and Dermatology Application: A Review

Zagórska‐Dziok

Sobczak

2020

Pharmaceutics

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“…Indeed, conventional therapies show low drug penetration, significant toxicity, and require high dosing frequency. [ 179 ] Phototherapy is a potential treatment which is not broadly adopted as it requires multiple sessions with associated low patient compliance and high costs. [ 179 ] For an efficient and improved treatment, it is important to design formulations with reduced cutaneous side effects, increased permeation through the skin surface, and minimal systemic side effects on kidney and liver, such as those induced by oral and injectable therapies.…”

Section: Topical Drug Delivery With Nanomaterialsmentioning

confidence: 99%

“…[ 180 ] Retinoids like tazarotene (topical) and acitretin (oral) are FDA approved drugs for psoriasis which inhibit inflammation and keratinocyte proliferation. [ 179 ] An acitretin‐niosome‐loaded gel improves the induction of orthokeratosis and reduces epithelial thickness compared to a commercial gel (Zarotex) and free acitretin in ex vivo skin models. [ 142,181 ] The niosome‐loaded gel does not cause any skin irritation and dose requirement is substantially reduced.…”

Section: Topical Drug Delivery With Nanomaterialsmentioning

confidence: 99%

Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery

Mustfa

Maurizi

McGrath

et al. 2020

Advanced Therapeutics

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Topical treatments have been widely adopted to address a broad range of conditions across multiple sites thanks to their convenience, versatility, and effectiveness. While bypassing systemic biobarriers and avoiding systemic side effects by delivering directly to the target tissue, topical treatments still face significant local biobarriers that limit their efficacy. The toolset available for nanodelivery systems and their inherent multifunctionality can contribute to simultaneously address otherwise intractable challenges related to barrier function evasion, drug solubility, bioavailability, pharmacokinetics, smart and sustained release, quantitative co‐delivery, and local targeting which are key to successful topical treatments. This review summarizes the outstanding challenges associated with the topical treatments of key diseases of the skin, mucosae, eyes, and ears, and highlights how nanodelivery systems are being developed to address them effectively.

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“…By minimizing systemic side effects, it allows for specific targeting of infected skin. However, patient satisfaction with the available topical treatment remains minimal [2]. Apremilast is an oral Phosphodiesterase Inhibitor (PDE4) approved by the US Food and Drug Administration in 2014 to treat moderate-tosevere plaque psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Topical Delivery of Apremilast Loaded Nanostructured Lipid Carrier Based Hydrogel for Psoriasis Therapy

Sindhoor

Koland

2021

JPRI

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Background: Apremilast (APR) is an orally administered selective phosphodiesterase 4 inhibitor approved to treat plaque psoriasis and psoriatic arthritis and is available as an oral tablet formulation. However, its systemic side effects limit its application. The low solubility and permeability of apremilast make it difficult to administer it through the skin. Hence an attempt is made to incorporate apremilast into a suitable nanocarrier to facilitate its topical delivery. Aims: To formulate and characterize Apremilast loaded nanostructured lipid carriers for the management of psoriasis to reduce the systemic side effects. Methodology: Apremilast loaded Nanostructured Lipid carriers (NLC) were prepared by melt emulsification accompanied by probe sonication. The formulation was prepared using GMS, Sefsol 218, Tween 80 and Transcutol P as Solid Lipid, Liquid lipid, Surfactant and Penetration Enhancer. The NLC was incorporated into carbapol 934 dispersion to convert it into a gel. The NLC formulation was evaluated for size, Polydispersity Index, Zeta Potential, Entrapment efficiency, Transmission Electron Microscopy. After that, the NLC gel was examined for Spreadability, Extrudabilty, Viscosity, In vitro drug release, Ex vivo permeation, Skin deposition and In vivo studies. Results: The formulated Apremilast loaded showed particle size of less than 200 nm (i.e.170.32nm) with a narrow PDI of 0.267. Entrapment efficiency revealed that 89.26±01.22% of the drug was entrapped. Transmission electron microscopy images confirmed the spherical nature of the nanocarrier. The extended-release pattern of the formulated NLC for 24h was observed in the in vitro release studies and followed the Higuchi model(R2=0.9966). Ex vivo permeability showed a 6.14 fold increase in permeability and 74.05±0.25% deposition of apremilast loaded NLC gel compared to apremilast gel. The formulation was stable for three months without significant changes. In vivo skin studies showed that the prepared NLC did not have any skin irritation potential. The antipsoriatic activity demonstrated by the Apremilast loaded NLC gel in the imiquimod induced psoriasis model in mice was comparable to the standard treatment. Conclusion: Apremilast loaded NLC demonstrated enhanced permeation, improved skin retention and extended-release compared to conventional gel. The developed formulation can be an alternative for psoriasis therapy after clinical trials in the future.

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Treatment of Psoriasis: Novel Approaches to Topical Delivery

Cited by 23 publications

References 51 publications

Hydrogel-Based Active Substance Release Systems for Cosmetology and Dermatology Application: A Review

Hydrogel-Based Active Substance Release Systems for Cosmetology and Dermatology Application: A Review

Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery

Topical Delivery of Apremilast Loaded Nanostructured Lipid Carrier Based Hydrogel for Psoriasis Therapy

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