Epigastric pain is a manifestation of several medical and surgical conditions. However, when persistent epigastric pain is associated with microscopic or frank haematuria and elevated lactate dehydrogenase (LDH), especially in patients with increased risk of thromboembolic events, acute renal infarction (ARI) should be considered. We report the case of a 77-year-old male patient who presented with sudden persistent epigastric pain and elevated LDH who was found to have atrial fibrillation. The patient was diagnosed with ARI. ARI is not usually a typical differential diagnosis in patients with persistent epigastric pain and elevated LDH in whom the risk of thromboembolic events is high. Thus, physicians should perform a contrast-enhanced CT scan as early as possible to rule out or confirm renal infarction. LEARNING POINTS • In acute kidney infarction, epigastric pain can be one of the clinical manifestations. • The combination of unexplained epigastric pain and elevated lactate dehydrogenase and haematuria in a patient with an increased risk of thromboembolic events should raise the suspicion of acute kidney infarction. • The physician should perform a contrast-enhanced CT scan as early as possible to rule out or confirm kidney infarction.