Treatment of retinal capillary hemangioma

Singh, Arun D.; Nouri, Mahnatz; Shields, Carol L.; Shields, Jerry A.; Padrón-Pérez, Noel

doi:10.1016/s0161-6420(02)01177-6

Cited by 183 publications

(136 citation statements)

References 34 publications

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“…For RCHs requiring treatment, laser photocoagulation and cryotherapy have been shown to be equally effective in controlling the growth of the lesion, as well as the associated retinal edema. In the same study by Singh and colleagues, 74% of treated RCHs remained controlled with one session of laser photocoagulation or cryotherapy [125].…”

Section: Retinal Capillary Hemangiomasmentioning

confidence: 82%

“…The majority of RCHs may be safely observed [125]. Singh et al reported that 82% (68 total patients) of observed RCH lesions remained stable with a mean follow up of 84 months [125].…”

Section: Retinal Capillary Hemangiomasmentioning

confidence: 99%

“…The majority of RCHs may be safely observed [125]. Singh et al reported that 82% (68 total patients) of observed RCH lesions remained stable with a mean follow up of 84 months [125]. For RCHs requiring treatment, laser photocoagulation and cryotherapy have been shown to be equally effective in controlling the growth of the lesion, as well as the associated retinal edema.…”

Section: Retinal Capillary Hemangiomasmentioning

confidence: 99%

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Cryotherapy in Ophthalmology

Tehrani¹,

Fraunfelder²

2013

OJOph

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Cryogens have been used to freeze living tissue for the purpose of treating benign and malignant lesions. Within the last century, ophthalmologists have found cryotherapy to be useful in treating a variety of ocular pathologies. Here, we review the history of cryotherapy, its introduction to the field of ophthalmology, its proposed mechanism of action, and its current applications in treating surface and intraocular eye disease.

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Section: Retinal Capillary Hemangiomasmentioning

confidence: 82%

“…The majority of RCHs may be safely observed [125]. Singh et al reported that 82% (68 total patients) of observed RCH lesions remained stable with a mean follow up of 84 months [125].…”

Section: Retinal Capillary Hemangiomasmentioning

confidence: 99%

Section: Retinal Capillary Hemangiomasmentioning

confidence: 99%

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Cryotherapy in Ophthalmology

Tehrani¹,

Fraunfelder²

2013

OJOph

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“…Patients were evaluated at the Ocular Oncology Service, Moorfields Eye Hospital, London (ie, patients [1][2][3][4] patients had juxtapapillary RCH, whereas one eye of one patient had peripheral RCH. All patients were treated with verteporfin PDT (Activis, Quantel Medical, Cournon d' Auvergne, France) with a single spot covering the lesion using Area Centralis lens (Volk, Mentor, OH, USA).…”

Section: Case Reportsmentioning

confidence: 99%

“…1 Studies using verteporfin photodynamic therapy (PDT) for both juxtapapillary and peripheral RCH have mixed anatomical and functional outcomes. [2][3][4][5][6][7][8][9][10][11] Post-PDT side effects such as vascular occlusion, optic neuropathy, and tractional retinal detachment (RD) have been reported.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy for retinal capillary hemangioma

Papastefanou

Pilli

Stinghe

et al. 2013

Eye

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Purpose To describe the results of photodynamic therapy (PDT) for juxtapapillary and peripheral retinal capillary hemangioma (RCH). Patients and methods Interventional case series of four eyes (four patients) with juxtapapillary RCH and one eye (one patient) with peripheral RCH. Two eyes with juxtapapillary RCH had received two sessions of full-fluence, double-duration PDT; whereas other two eyes had received single session of half-fluence, single-duration PDT. The peripheral RCH was treated with a single session of full-fluence, single-duration PDT. Results Two patients had von HippelLindau disease. Follow-up duration ranged from 4 months to 1 year. Pre-PDT visual acuity (VA) ranged from 20/200 to HM (juxtapapillary RCH) and 20/100 (peripheral RCH). Among the eyes with juxtapapillary RCH, tumor regression with partial resolution of macular edema was noted in two eyes (one eye each with half-fluence and full-fluence PDT), whereas two eyes had no change in tumor size with persistent macular edema. VA remained stable in three eyes and declined in one eye. In an eye with peripheral RCH, regression of tumor and macular edema with VA improvement was noted. Post-PDT complications included epiretinal membrane (one eye) and transient exudative retinal detachment (one eye). Conclusion PDT can be effective in reducing macular edema associated with RCH but this does not always correspond with an improvement in VA especially for juxtapapillary tumors.

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Three Cases of Large Retinal Capillary Hemangiomas Treated With Verteporfin and Photodynamic Therapy

et al. 2005

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Objective: To investigate the efficacy of verteporfin and photodynamic therapy in the treatment of large retinal capillary hemangiomas.Methods: Case reports of 3 patients with large retinal capillary hemangiomas treated with photodynamic therapy using verteporfin. Standard verteporfin dosages (6 mg/m 2 of body surface area) were given. Both standard and modified photodynamic protocols were followed. Modified protocols included shorter verteporfin infusion times and longer light exposure times.Results: Pretreatment best-corrected Snellen visual acuity of the 3 affected eyes were 20/100, 20/50, and 2/200, respectively. All cases had associated exudative retinal detachments involving the macula. Cases 1 and 2 were classic endophytic retinal capillary hemangiomas. Case 3 was a reactive retinal capillary hemangioma. Case 1 had 2 photodynamic therapy treatments, and after 8 months, visual acuity improved to 20/40. Two years after initiating photodynamic therapy, the visual acuity was 20/30 and there was no reperfusion of the hemangioma. Case 2 had 3 photodynamic therapy treatments. The hemangioma was fibrotic, and 20 months after initiating photodynamic therapy visual acuity improved to 20/30. Case 3 had 1 treatment, 11 weeks later and visual acuity improved to 20/400. Four months after treatment, visual acuity returned to counting fingers because of tractional elevation of the macula as the capillary hemangioma fibrosed. Vitrectomy surgery was performed, and choroidal and retinal neovascularization was discovered. Three months after vitrectomy visual acuity was 20/ 400. In cases 1 and 2, the capillary hemangioma ultimately regressed, and the exudative detachment resolved.Conclusions: Verteporfin and photodynamic therapy were effective in achieving closure of large retinal capillary hemangiomas. In all cases, the hemangioma underwent fibrosis with consequent macular puckering due to retinal traction. In all cases, the visual acuity improved.

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Treatment of retinal capillary hemangioma

Cited by 183 publications

References 34 publications

Cryotherapy in Ophthalmology

Cryotherapy in Ophthalmology

Photodynamic therapy for retinal capillary hemangioma

Three Cases of Large Retinal Capillary Hemangiomas Treated With Verteporfin and Photodynamic Therapy

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