Treatment of rotaviral gastroenteritis with Qiwei Baizhu powder

Abstract

AIM To observe the effects of Qiwei Baizhu Powder (QWBZP) on rotaviral gastroenteritis in children and in animal models.METHODS Enrolled patients were divided into two groups, and one group was treated with oral rehydration solution (ORS) and the other treat ed with oral liquid of QWBZP. Neonate mice were orally infected with 50 µ µ µ µ µL rotavirus suspension (4×10 8 PFU/mL) and treated with ORS or oral liquid of QWBZP, respectively.RESULTS Eighty-three cases of rotaviral gastroenteritis treated with QWBZP revealed a better efficacy than that treated with ORS (χ χ χ χ χ 2 = 10.87, P<0.05). The contents of sodium and glucose as well as number of patients with positive human rotavirus antigen in stool in QWBZP group were all less than that in ORS group. In a nimal models, QWBZP was found effective in treating rotavirus gastroenteritis in neonate NIH mice, as compared with control groups. In QWBZP group, the mortality of infected mice was decreased by 73.3%, the body weight of infected mice was increased, the contents of sodium and glucose as well as number of mice with positive rotavirus antigen in feces were significantly reduced, and the pathological changes such as damage of small intestinal mucosa and villi were also obviously alleviated.CONCLUSION QWBZP has effects on improving the absorptive function of small intestine, shortening the duration of diarrhea and rotavirus shedding from stool and alleviating the pathological changes of small intestine induced by rotavirus.Subject headings gastroenteritis/drug therapy; rotavirus infections/drug therapy; Qiwei baizhu powder/therapeutic use; disease models, animal

Advances in the development of antivirals for rotavirus infection

“…The relief of diarrhoea in rotavirus infected piglets by lentinan administration may be the result of improved intestinal microbiota and attenuation of apoptosis (145). Animal tests of Qiwei Baizhu powder confirmed that the drug reduces pathological damage such as small intestinal mucosa and villi damage and improves small intestinal absorption (146). Oral administration of transforming growth factor alpha promotes the recovery of mucosal damage induced by rotavirus enteritis in pigs (147).…”

Preventive Effects of Pyungwi-san against Dextran Sulfate Sodium- and Clostridium difficile-Induced Inflammatory Bowel Disease in Mice

“…Accumulating evidence indicates the usefulness of PWS in the treatment of common gastrointestinal disorders, such as gastritis, esophageal reflux, gastric or duodenal ulcers, and acute or chronic enteritis [43]. It has been revealed that RAM prevents virus-induced gastroenteritis via the protection of intestinal mucosal cells against injury and improvement in the absorption [44]. However, the effect of PWS on acute colitis has not yet been described in detail.…”