Treatment of Severe Acute Respiratory Syndrome With Glucosteroids

Chen, Rong Chang; Tang, Xiaojing; Tan, Shou Yong; Liang, Biao; Wan, Zhuo Yue; Fang, Ji Qian; Zhong, Nanshan

doi:10.1378/chest.129.6.1441

Cited by 281 publications

(277 citation statements)

References 26 publications

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“…In a retrospective study of patients with SARS-CoV and sepsis, steroids, in a mean daily dose of 105.3 +/-86.1 mg in 147 of 249 noncritical patients (59.0%) reduced mortality and shortened duration of hospitalization, while 121 of 152 critical patients (79.6%) received corticosteroids at a mean daily dose of 133.5 +/-102.3 mg, and 25 died 25 . A subsequent retrospective observational study of 309 MERS patients showed that those who received high dose steroids were more likely to require mechanical ventilation, vasopressors and RRT 26 .…”

Section: Glucocorticoidsmentioning

confidence: 99%

The Novel Coronavirus 2019 epidemic and kidneys

Naicker

Yang

Hwang

et al. 2020

Kidney International

599

606

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Section: Glucocorticoidsmentioning

confidence: 99%

The Novel Coronavirus 2019 epidemic and kidneys

Naicker

Yang

Hwang

et al. 2020

Kidney International

599

606

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“…Retrospective analysis of SARS‐CoV patients showed no benefit of corticosteroid administration except when critical cases were analyzed alone and death‐related variables were adjusted. Among these critical patients, corticosteroid therapy did significantly reduce case fatality (Chen, ). Similarly, corticosteroids have been used in some MERS‐CoV patients with severe disease (Assiri et al .,; Guberina et al ., ; Memish et al .,; Omrani et al ., ).…”

Section: Mers‐cov Intervention Strategiesmentioning

confidence: 99%

The emergence of the Middle East Respiratory Syndrome coronavirus

2014

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On September 20, 2012, a Saudi Arabian physician reported the isolation of a novel coronavirus from a patient with pneumonia on ProMED-mail. Within a few days the same virus was detected in a Qatari patient receiving intensive care in a London hospital, a situation reminiscent of the role air travel played in the spread of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) in 2002. SARS-CoV originated in China’s Guangdong Province and affected more than 8000 patients in 26 countries before it was contained six months later. Over a year after the emergence of this novel coronavirus—Middle East Respiratory Syndrome coronavirus (MERS-CoV)—it has caused 178 laboratory confirmed cases and 76 deaths The emergence of a second highly pathogenic coronavirus within a decade highlights the importance of a coordinated global response incorporating reservoir surveillance, high-containment capacity with fundamental and applied research programs, and dependable communication pathways to ensure outbreak containment. Here we review the current state of knowledge on the epidemiology, ecology, molecular biology, clinical features and intervention strategies of the novel coronavirus, MERS-CoV.

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“…In recent years, infectious agents have become the most important factors in ARDS, especially the avian influenza virus and severe acute respiratory syndrome (SARS) coronavirus [5][6][7][8]. CHEN et al [9] investigated the efficacy and safety profiles of corticosteroid therapy in SARS patients, and reported that the proper use of corticosteroids in confirmed critical SARS resulted in lower mortality and shorter hospital stay. MEDURI and co-workers [10,11] reported that prolonged administration of methylprednisolone in patients with unresolving ARDS significantly improved pulmonary and extrapulmonary organ dysfunction and reduced mortality.…”

mentioning

confidence: 99%

Effect of dexamethasone on acute respiratory distress syndrome induced by the H5N1 virus in mice

Xu¹,

Jian²,

Zhao³

et al. 2009

Eur Respir J

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Glucocorticoids are widely used in the treatment of different inflammatory diseases. The present study was performed to investigate the effect of dexamethasone (DEX) on acute respiratory distress syndrome (ARDS) induced by the H5N1 viral infection in mice.BALB/c mice, 6-8 weeks old, were divided into three groups with 80 mice in each. The infected group and the DEX-treated infected group were inoculated intranasally with 1610 2 50% mouse infectious dose of A/Chicken/Hebei/108/2002 (H5N1) viruses, with daily intraperitoneal injections of PBS, or 2.5 mg?kg -1 DEX at days 3-14 post inoculation, respectively. The control group received noninfectious allantoic fluid and a daily intraperitoneal injection of PBS. In H5N1-infected mice, DEX treatment did not improve the mortality (17 out of 20 versus 16 out of 20 deaths in the DEX-treated infected group versus the infected group), and did not alleviate clinical signs, including weight loss, decreased food intake and inactivity. There was no significant amelioration of the hypoxaemia and ARDS-associated pathological changes in DEXtreated infected mice, as assessed by blood gas analysis and histological score. Furthermore, DEX therapy did not inhibit inflammatory cellular infiltration and cytokine release (interleukin-6 and tumour necrosis factor-a) in bronchoalveolar lavage fluid induced by the H5N1 infection.In conclusion, dexamethasone treatment (2.5 mg?kg -1 ) from days 3-14 post inoculation has no beneficial effect on acute respiratory distress syndrome caused by the H5N1 infection in mice.

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Treatment of Severe Acute Respiratory Syndrome With Glucosteroids

Abstract: This Guangzhou retrospective study revealed that proper use of corticosteroid in confirmed critical SARS resulted in lowered mortality and shorter hospitalization stay, and was not associated with significant secondary lower respiratory infection and other complications.

Cited by 281 publications

References 26 publications

The Novel Coronavirus 2019 epidemic and kidneys

The Novel Coronavirus 2019 epidemic and kidneys

The emergence of the Middle East Respiratory Syndrome coronavirus

Effect of dexamethasone on acute respiratory distress syndrome induced by the H5N1 virus in mice

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