Treatment of Severe Postmenopausal Endometriosis With an Aromatase Inhibitor

Takayama, Ken‐ichi; Zeitoun, Khaled; Gunby, Robert T.; Sasano, Hironobu; Carr, Bruce R.; Bulun, Serdar E.

doi:10.1016/s0015-0282(98)00022-3

Cited by 253 publications

(157 citation statements)

References 5 publications

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“…One study, using the Japanese quail, has shown that administration of an aromatase antagonist can reverse gonadectomyinduced decreases in the nociceptive threshold (Evrard and Balthazart, 2003). Furthermore, aromatase inhibitors have shown promise in the treatment of pelvic pain associated with endometriosis (Takayama et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

The organizational and activational effects of sex hormones on tactile and thermal hypersensitivity following lumbar nerve root injury in male and female rats

LaCroix-Fralish

Tawfik

DeLeo

2005

Pain

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Considerable evidence exists for sex differences in human pain sensitivity. Women typically report a higher incidence of various painful conditions and report that the conditions are more painful when compared to men. In the present study, we sought to determine whether sex differences in pain sensitivity are observed using a lumbar radiculopathy model of low back pain in the rat and whether removal or alteration of gonadal hormones at specific timepoints can modulate these sex differences. Pubertal and adult male and female Sprague-Dawley rats were castrated 2 or 6 weeks prior to L5 nerve root injury to determine the activational hormonal effects. In a separate study, neonatal male and female Sprague-Dawley rats were either castrated or injected with testosterone, respectively, on postnatal day one to determine the organizational effects of gonadal hormones on L5 nerve root injury-induced behavioral hypersensitivity. Our results demonstrate that there was a statistically significant sex difference in the magnitude of mechanical allodynia and thermal hyperalgesia following experimentally induced radiculopathy in the rat: females demonstrated decreased thresholds to tactile and thermal stimuli as compared to males. Furthermore, the enhanced female hypersensitivity was reversed in pubertal and adult animals ovariectomized 6 weeks, but not 2 weeks prior to L5 nerve root injury. Our results demonstrate that the activational effects of gonadal hormones mediate the enhanced female tactile and thermal hypersensitivity following L5 nerve root injury. These results suggest that manipulation of gonadal hormones may be a potential source for novel therapies for chronic pain in women.

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Section: Discussionmentioning

confidence: 99%

The organizational and activational effects of sex hormones on tactile and thermal hypersensitivity following lumbar nerve root injury in male and female rats

LaCroix-Fralish

Tawfik

DeLeo

2005

Pain

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show abstract

“…12 Previous studies demonstrated that transvaginal ultrasonography was able to assess the mass in the pelvic and to distinguish between ovarian endometriosis and other ovarian masses. 10 Transvaginal ultrasonography has a sensitivity of 84% and specificity of 90% in the ovarian mass. 12 In this study, 32 cases were diagnosed with adenomyosis using transvaginal USG.…”

Section: Discussionmentioning

confidence: 99%

Management of adenomyosis in infertile women: comparison between laparotomic resection and administration of aromatase inhibitor (<em>Experience in 55 cases</em>)

Rajuddin¹,

Jacoeb²

2006

Med J Indones

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“…Sonuç olarak, aromataz inhibitörlerinin endometriyozis tedavisinde etkili bir seçim olabileceği beyan edilmiştir. 9 Ferroro ve ark.nın 2013 yılında yayımlanan ça-lışmasında, laparoskopik veya laparotomik olarak derin endometriyozisi eksize edilemeyen ve histopatolojik tanı almış, postoperatif ağrısı olan 35 premenopozal kadına günde 2,5 mg letrazol, 1000 mg kalsiyum, 880 IU vitamin D3 (calcit vitamina D3) verilmiştir. Bu hastaların 18'ine üç ayda bir intramusküler depo triptorelin (11,25 decapeptyl), 17'sine de oral norethisterone asetat (2,5 mg/gün primolutnor), altı ay boyunca ilave olarak verilerek, dismenore, nonmenstrüel ağrı ve derin disparoninin şiddeti tedavi süresince vizüel analog skala (VAS) skorlaması ile değerlendirilmiştir.…”

Section: Aromataz İnhi̇bi̇törleri̇unclassified

Treatment of Endometriosis with Non-Hormonal Agents: Review

Özdemirci¹,

Dilbaz²

2016

Turkiye Klinikleri J Gynecol Obst

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Treatment of Severe Postmenopausal Endometriosis With an Aromatase Inhibitor

Cited by 253 publications

References 5 publications

The organizational and activational effects of sex hormones on tactile and thermal hypersensitivity following lumbar nerve root injury in male and female rats

The organizational and activational effects of sex hormones on tactile and thermal hypersensitivity following lumbar nerve root injury in male and female rats

Management of adenomyosis in infertile women: comparison between laparotomic resection and administration of aromatase inhibitor (<em>Experience in 55 cases</em>)

Treatment of Endometriosis with Non-Hormonal Agents: Review

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