Treatment of skin injuries induced by sulfur mustard with calmodulin antagonists, using the pig model

Characterization of acute and long-term sulfur mustard-induced skin injuries in hairless guinea-pigs using non-invasive methods

“…The model we have established was based on previous reports in the literature that described the use of anesthetized HGP (1, 25, 26, 34); however, in our experiment, exposure to HD was conducted on awake animals only, as there might be an interaction between anesthetic drugs and the tested treatments (19, 35, 36). Following exposure and decontamination, animals were returned to their cages for further monitoring up to 2 weeks.…”

“…Because of its anatomical, physiological and biochemical similarity to human skin, pig skin is the preferred model for skin injury research (19–21), but as the pig is a large animal, experiments can be conducted only on limited numbers. The mouse ear vesicant model (MEVM) (15, 16) is very useful in studying the parameters of inflammation and histopathological changes during the acute phase of HD injury.…”

Flavonoid Treatment for Mustard Agents' Toxicity

“…Sulphur mustard is a potent cutaneous vesicant. Sulphur mustard penetrates rapidly through the skin, causing prolonged injuries and leading to severe incapacitation (Kadar et al, 2000). The proliferating basal cells in the skin are metabolically very active and are more sensitive to SM (Ray et al, 2000).…”

Swine models in the design of more effective medical countermeasures against organophosphorus poisoning

“…injuries, wound healing and burn management (Kadar et al, 2000;Rice et al, 2000). This review will focus on OP toxicology.…”