Treatment of Squamous Cell Carcinoma of the Anus, Unresolved Areas and Future Perspectives for Research: Perspectives of Research Needs in Anal Cancer

Guren, Marianne G.; Sebag‐Montefiore, David; Franco, Pierfrancesco; Johnsson, Anders; Segelov, Eva; Deutsch, Éric; S, Rao; Spindler, Karen Lise Garm; Arnold, Dirk

doi:10.1016/j.clcc.2021.09.006

Cited by 8 publications

(4 citation statements)

References 106 publications

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“…In 2020 and 2021, clinicians and researchers organized two International Multidisciplinary Anal Cancer Conference (IMACC) Webinars. There was also a physical meeting held in Aarhus, Denmark, in 2021 [ 4 , 20 ]. These meetings presented an opportunity to discuss several potential topics and open issues for future collaborations, including the implementation of global prospective registries to record outcomes of specific patient subgroups, the harmonization of clinical-trial designs and outcomes to facilitate data pooling and analysis, and the need and rationale for developing biological and translational studies [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, this clinical-pathological entity is regarded as a matter for global public health attention, with a focus on primary and secondary prevention, treatment and survivorship [ 3 ]. Given the rarity of the disease, barriers have been encountered when carrying out clinical trials to establish standard treatment strategies and to conduct translational research projects to shed light into its biology and molecular characterization [ 4 , 5 ]. However, despite these, ASCC has been a prime example of national and international collaborations, networking abilities, organizational proficiency and leadership.…”

Section: Introductionmentioning

confidence: 99%

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A Machine-Learning-Based Bibliometric Analysis of the Scientific Literature on Anal Cancer

Franco

Segelov

Johnsson

et al. 2022

Cancers

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Squamous-cell carcinoma of the anus (ASCC) is a rare disease. Barriers have been encountered to conduct clinical and translational research in this setting. Despite this, ASCC has been a prime example of collaboration amongst researchers. We performed a bibliometric analysis of ASCC-related literature of the last 20 years, exploring common patterns in research, tracking collaboration and identifying gaps. The electronic Scopus database was searched using the keywords “anal cancer”, to include manuscripts published in English, between 2000 and 2020. Data analysis was performed using R-Studio 0.98.1091 software. A machine-learning bibliometric method was applied. The bibliometrix R package was used. A total of 2322 scientific documents was found. The average annual growth rate in publication was around 40% during 2000–2020. The five most productive countries were United States of America (USA), United Kingdom (UK), France, Italy and Australia. The USA and UK had the greatest link strength of international collaboration (22.6% and 19.0%). Two main clusters of keywords for published research were identified: (a) prevention and screening and (b) overall management. Emerging topics included imaging, biomarkers and patient-reported outcomes. Further efforts are required to increase collaboration and funding to sustain future research in the setting of ASCC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Machine-Learning-Based Bibliometric Analysis of the Scientific Literature on Anal Cancer

Franco

Segelov

Johnsson

et al. 2022

Cancers

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“…During follow-up, it is crucial to evaluate and take care of eventual conditions affecting the anorectal and sexual function, together with urinary continence [4]. Treatment decisions, follow-up examinations and interventions are taken by the radiation oncologist, relying on a shared decision-making process taken within the tumor board, which is considered a fundamental instrument to improve patient care in this setting [36].…”

Section: Discussionmentioning

confidence: 99%

A Pattern of Care Report on the Management of Patients with Squamous Cell Carcinoma of the Anus—A Study by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Tumors Study Group

et al. 2021

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Background and objectives: The diagnosis and therapy of squamous cell carcinoma of the anus may vary significantly in daily clinical practice, even if international guidelines are available. Materials and Methods: We conducted a pattern of care survey to assess the management of patients with anal cancer in Italy (38 questions). We analyzed 58 questionnaires. Results: Most of the respondents work in public and/or university hospitals (75.8%) in northern Italy (65.5%). The majority (88.0%) treat less than 20 patients/year. Common examinations for diagnosis and staging are anorectal endoscopy (84.5%), computed tomography scan (86.2%) and pelvic magnetic resonance imaging (MRI) (96.5%). The most frequently prescribed dose to primary tumor is 50–54 Gy (46.5–58.6%) for early stage disease and 54–59.4 Gy (62.1–32.8%) for locally advanced cases. Elective volumes are prescribed around 45 Gy (94.8%). Most participants use volumetric intensity modulated radiotherapy (89.7%) and a simultaneous integrated boost (84.5%). Concurrent radiotherapy, 5-fluorouracil and mitomycin is considered the standard of care (70.6%). Capecitabine is less frequently used (34.4%). Induction chemotherapy is an option for extensive localized disease (65.5%). Consolidation chemotherapy is rarely used (18.9%). A response evaluation is conducted at 26–30 weeks (63.9%) with a pelvic MRI (91.4%). Follow-up is generally run by the multidisciplinary tumor board (62.1%). Conclusions: Differences were observed for radiotherapy dose prescription, calling for a consensus to harmonize treatment strategies.

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“…Although relatively sensitive to chemoradiotherapy, local recurrence requires salvage surgery with significant morbidity and is associated with poor outcomes. A better understanding of anal cancer biology is a recognised unmet research need 1 that Hamza and colleagues set out to address 2 . Surgical samples from 158 anal cancer patients with abdominoperineal resections following first line chemoradiotherapy (or radiotherapy alone) were assessed for pathogenic variants in 571 cancer‐related genes, focusing on prognostic and targetable mutations.…”

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Understanding the molecular biology of anal squamous cell carcinoma

Samuel,

Gilbert

2023

Intl Journal of Cancer

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Anal squamous cell carcinomas (ASCC) are strongly associated with prior infection with high-risk human papilloma viruses (HPV).Although relatively sensitive to chemoradiotherapy, local recurrence requires salvage surgery with significant morbidity and is associated with poor outcomes. A better understanding of anal cancer biology is a recognised unmet research need 1 that Hamza and colleagues set out to address. 2 Surgical samples from 158 anal cancer patients with abdominoperineal resections following first line chemoradiotherapy (or radiotherapy alone) were assessed for pathogenic variants in 571 cancer-related genes, focusing on prognostic and targetable mutations. Mutations in PIK3CA and KMT2C were found to be associated with worse outcomes (overall survival) in HPV+ve patients, with 40% of all patients having targetable mutations. We congratulate the authors on a comprehensive analysis of a larger number of patients with a rare disease that supports including these patients in trials of precision medicine.As with other mucosal squamous cell carcinomas, the HPV status of SCCA is associated with improved outcomes after initial radical treatment 3 but does not yet alter treatment approaches or regimens.Given that 90%-95% of SCCA patients are HPV+ve, there is a higher absolute number of HPV+ve SCCA patients that relapse after firstline treatment. The differences in mutational profiles between these

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Treatment of Squamous Cell Carcinoma of the Anus, Unresolved Areas and Future Perspectives for Research: Perspectives of Research Needs in Anal Cancer

Cited by 8 publications

References 106 publications

A Machine-Learning-Based Bibliometric Analysis of the Scientific Literature on Anal Cancer

A Machine-Learning-Based Bibliometric Analysis of the Scientific Literature on Anal Cancer

A Pattern of Care Report on the Management of Patients with Squamous Cell Carcinoma of the Anus—A Study by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Tumors Study Group

Understanding the molecular biology of anal squamous cell carcinoma

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