Treatment of telogen effluvium using a dietary supplement containing
 Boswellia serrata
 ,
 Curcuma longa
 , and
 Vitis vinifera
 : Results of an observational study

Nisticò, Steven Paul; Tamburi, Federica; Bennardo, Luigi; Dastoli, Stefano; Schipani, Giusy; Caro, Gemma; Fortuna, Maria Caterina; Rossi, Alfredo

doi:10.1111/dth.12842

Cited by 41 publications

(26 citation statements)

References 8 publications

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“…Curcumin, also known as turmeric, is a polyphenol derived from curcumin longa, and is traditionally used in various Asian cuisine [20]. Recently, curcumin has been studied to adjunctly treat broad spectrum of disease from type 2 diabetes mellitus to telogen effluvium [21]. Curcumin elicits antidiabetic effects via several mechanisms, including the increase in glycolysis and glycogen synthesis and the decrease in gluconeogenesis in the liver, as well as the increase in glucose uptake, glycolysis, and glycogen synthesis in the skeletal muscle [22].…”

Section: Introductionmentioning

confidence: 99%

Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis

Chien

Chang

et al. 2021

Nutrients

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The therapeutic effects of curcumin for polycystic ovary syndrome (PCOS) remain inconclusive. The present study aims to evaluate the effects of curcumin on glycemic control and lipid profile in patients with PCOS. PubMed, Embase, Scopus, Web of Science, and Cochrane Library were searched from the inception through 28 November 2020. Randomized control trials (RCTs), which enrolled adult patients with PCOS, compared curcumin with placebo regarding the glycemic control and lipid profile, and reported sufficient information for performing meta-analysis, were included. Three RCTs were included. Curcumin significantly improves fasting glucose (mean difference (MD): −2.77, 95% confidence interval (CI): −4.16 to −1.38), fasting insulin (MD: −1.33, 95% CI: −2.18 to −0.49), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (MD: −0.32, 95% CI: −0.52 to −0.12), and quantitative insulin sensitivity check index (QUICKI) (MD: 0.010, 95% CI: 0.003–0.018). It also significantly improves high-density lipoprotein (MD: 1.92, 95% CI: 0.33–3.51) and total cholesterol (MD: −12.45, 95% CI: −22.05 to −2.85). In contrast, there is no statistically significant difference in the improvement in low-density lipoprotein (MD: −6.02, 95% CI: −26.66 to 14.62) and triglyceride (MD: 8.22, 95% CI: −26.10 to 42.53) between curcumin and placebo. The results of the fasting glucose, fasting insulin, HOMA-IR, QUICKI, and total cholesterol are conclusive as indicated by the trial sequential analysis. Curcumin may improve glycemic control and lipid metabolism in patients with PCOS and metabolic abnormality without significant adverse effects. Further studies are advocated to investigate the potential effects of curcumin on hyperandrogenism.

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Section: Introductionmentioning

confidence: 99%

Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis

Chien

Chang

et al. 2021

Nutrients

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“…C. domestica Valeton and C. brog Valeton) ( Zingiberaceae ) used as a culinary spice in curry powder [ 19 ]. The antioxidant and anti-inflammatory properties of curcumin [ 20 , 21 ] could be attributed to its antinociceptive activity against different pain conditions, including peripheral neuropathic, inflammatory, postoperative, burn pain, and wound healing [ 22 , 23 , 24 , 25 ], as well as its use as an oral supplement in the treatment of various inflammatory medical conditions, such as alopecia [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review

Basu

Maier

Basu

2021

IJMS

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Lesion or disease of the somatosensory system leads to the development of neuropathic pain. Peripheral neuropathic pain encompasses damage or injury of the peripheral nervous system. On the other hand, 10–15% of individuals suffer from acute postoperative pain followed by persistent pain after undergoing surgeries. Antidepressants, anticonvulsants, baclofen, and clonidine are used to treat peripheral neuropathy, whereas opioids are used to treat postoperative pain. The negative effects associated with these drugs emphasize the search for alternative therapeutics with better efficacy and fewer side effects. Curcumin, a polyphenol isolated from the roots of Curcuma longa, possesses antibacterial, antioxidant, and anti-inflammatory properties. Furthermore, the low bioavailability and fast metabolism of curcumin have led to the advent of various curcumin formulations. The present review provides a comprehensive analysis on the effects of curcumin and its formulations in preclinical and clinical studies of neuropathic and postoperative pain. Based on the positive outcomes from both preclinical and clinical studies, curcumin holds the promise of mitigating or preventing neuropathic and postoperative pain conditions. However, more clinical studies with improved curcumin formulations are required to involve its use as adjuvant to neuropathic and postoperative drugs.

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“…Moreover, CU is able to disintegrate preformed Aβ fibrils [ 18 ], reduce insoluble Aβ deposits and amyloid plaques [ 20 ]. Curcumin has already been used as a supplement for the treatment of various medical conditions such as: hair loss [ 21 ], inflammations [ 22 ], microbial and parasitic infections [ 23 , 24 ], different types of cancers [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders

et al. 2021

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The acetylcholinesterase (AChE) inhibitors are the main drugs for symptomatic treatment of neurodegenerative disorders like Alzheimer’s disease. A recently designed, synthesized and tested hybrid compound between the AChE inhibitor galantamine (GAL) and the antioxidant polyphenol curcumin (CU) showed high AChE inhibition in vitro. Here, we describe tests for acute and short-term toxicity in mice as well as antioxidant tests on brain homogenates measured the levels of malondialdehide (MDA) and glutathione (GSH) and in vitro DPPH, ABTS, FRAP and LPO inhibition assays. Hematological and serum biochemical analyses were also performed. In the acute toxicity tests, the novel AChE inhibitor given orally in mice showed LD50 of 49 mg/kg. The short-term administration of 2.5 and 5 mg/kg did not show toxicity. In the ex vivo tests, the GAL-CU hybrid performed better than GAL and CU themselves; in a dose of 5 mg/kg, it demonstrates 25% reduction in AChE activity, as well as a 28% and 73% increase in the levels of MDA and GSH, respectively. No significant changes in blood biochemical data were observed. The antioxidant activity of 4b measured ex vivo was proven in the in vitro tests. In the ABTS assay, 4b showed radical scavenging activity 10 times higher than the positive control butylhydroxy toluol (BHT). The GAL-CU hybrid is a novel non-toxic AChE inhibitor with high antioxidant activity which makes it a prospective multitarget drug candidate for treatment of neurodegenerative disorders.

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Treatment of telogen effluvium using a dietary supplement containing Boswellia serrata , Curcuma longa , and Vitis vinifera : Results of an observational study

Cited by 41 publications

References 8 publications

Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis

Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis

Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review

A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders

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