Treatment of the hepatitis C virus in patients coinfected with HIV

Khalili, Mandana; Proietti, Nicole

doi:10.1016/j.gtc.2004.04.002

Cited by 2 publications

(2 citation statements)

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“…In a limited number of studies, treatment with a pegylated interferon and ribavirin regimen has yielded some encouraging responses in some of these patients, but the sustained virological response rates were lower than those observed in patients with HCV mono-infection [72,126,146]. The interactions between virus and host are crucial to the survival of both HIV-1 and HCV in host cells, thus future investigations into possible interference or synergism between the viral proteins of these two viruses will have important implications for the treatment and management of HIV/HCV coinfection.…”

Section: Discussionmentioning

confidence: 98%

“…This alarming prevalence of coinfections of the HIV-1 and HCV is of increasing clinical relevance, especially since the findings of several cohorts studies showed that coinfected patients suffered from high mortality that is usually related to liver diseases. The detailed findings of these studies are summarized in recent reviews [20,23,72,126,137,146]. Indeed, it seems that HIV/HCV coinfected patients treated with highly active antiretroviral therapy (HAART) may face a higher risk of liver disease, and the increase in liver toxicity associated with the HAART regimen is at least partly responsible for accelerating the progression to liver cirrhosis, hepatocellular carcinoma or other liver diseases.…”

Section: Introductionmentioning

confidence: 99%

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Understanding Human Immunodeficiency Virus Type 1 and Hepatitis C Virus Coinfection

Tan

Lim²,

Hong³

2006

CHR

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In recent years, there has been an alarming increase in the number of cases of coinfection with the human immunodeficiency virus type 1 (HIV-1) and the hepatitis C virus (HCV). It is now known that coinfection of HIV-1 patients by HCV can complicate the treatment of these patients with highly active antiretroviral therapy and the interactions between anti-HIV-1 and anti-HCV medications can also affect treatment efficacy and efficiency. Equally concerning, the bidirectional interferences between the two viruses are complex and can modify the natural history of both infections. This review aims to summarize the findings of numerous scientific investigations in the area of HIV/HCV coinfection. These investigations can be broadly classified into 3 groups; (a) immune evasion mechanisms (b) viral evolution and quasispecies diversity and (c) functions of viral proteins and their interactions with host factors. Our cumulative knowledge in this area and future research on the interplay between these two viruses will be important to the development of better antiviral therapeutics.

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Section: Discussionmentioning

confidence: 98%