Treatment of Triple-Negative Breast Cancer

One of the main priorities in modern oncology is the identification and clinical application of biomarkers that can be helpful in the diagnostics and prognostication of cancer. The aim of this article was to review biomarkers for early diagnosis and prediction of prognosis of breast cancer. There were reviewed three main groups of biomarkers in this article: familial breast cancer biomarkers with high and low penetration (BRCA1, BRCA2, TP53, etc.), biomarkers of breast cancer molecular subtypes (luminal A and luminal B, HER2/neu, basal and low in claudine) and biomarkers of early stage breast cancer progression (multigenic panels).

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The role of biomarkers in the early diagnostics of breast cancer

Исмагилов

Хузина²,

Ванесян³

et al. 2021

Opuholi ženskoj reproduktivnoj sistemy

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The overview of modern approaches in treatment of triple negative breast cancer

Харитонова

Смирнова

Kiseleva

2020

Issled. prakt. med. (Print)

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By far the most aggressive subtype of breast cancer is triple negative cancer. The purpose of this review is to analyze current ideas about the pathogenesis, clinical characteristics of different subtypes of triple negative breast cancer, the nature of its metastasis, mechanisms of chemoresistance. The review presents the results of modern regimens of drug therapy of triple negative breast cancer according to the publications of domestic and foreign oncologists. On the basis of various clinical studies, the effectiveness of the use of anthracyclines, taxanes in the dose-dense regime, platinum preparations and other chemotherapy drugs for the treatment of triple-negative cancer has been shown. The presented treatment regimens allow to achieve a complete morphological response in 85% of patients, to increase the rates of relapse-free and overall survival, comparable with other subtypes of breast cancer. The review highlights the possibilities of modern targeted drugs-PARP inhibitors, chk1 inhibitors UCN‑01, immunotherapy possibilities for the treatment of this aggressive subtype of breast cancer.

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Treatment of Triple-Negative Breast Cancer

Cited by 2 publications

References 4 publications

The role of biomarkers in the early diagnostics of breast cancer

The role of biomarkers in the early diagnostics of breast cancer

The overview of modern approaches in treatment of triple negative breast cancer

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