Treatment of Tuberculosis With Sulphetrone

Sulphetrone: Therapeutics and Toxicology

“…That an essentially similar condition develops in man is im plicit in the case reportea by Madigan (1948), Anderson and Strachan (1948), and Clay and Clay (1948) . The problem was studied intensively in 2 female patients presenting bilateral fibro caseous disease, and both at first gravely ill. Sulphetrone-balarice experiments were.…”

“…Nevertheless, during this period of adjustment mild symptoms of toxicity are seen (Madigan 1948 The results of an experiment on dogs in which sulphetrone was injected first into the large and then into the small intestine, the ileocecal junction having been tied, support the view that absorptioa is largely confined to the small intestine. It follows that optimal conditions of absorption are likely to follow uniformly divided doses.…”