Treatment of Tumoral Calcinosis with Phosphorus Deprivation

Mozaffarian, G.

doi:10.7326/0003-4819-77-5-741

Cited by 92 publications

(39 citation statements)

References 15 publications

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“…Most patients reported in the literature were adolescents or young adults and were from the tropical and subtropical regions of Africa [1,22,30,31,42]. Hyperphosphatemia has been found in some individuals, but serum calcium and parathyroid hormone levels are reported normal [3,21,22,24,26,32,34,35,38,45]. An apparent inherited disorder of phosphate and vitamin D metabolism has also been described [8,19,28,34,37,38,48].…”

Section: Discussionmentioning

confidence: 99%

Tumoral calcinosis-like lesion of the proximal linea aspera

et al. 1990

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Abstract. Tumoral calcinosis is presently a poorly defined disease. In its classic form, it consists of multiple large foci of benign mineralization in the soft tissuc adjacent to bone near large joints. Patients are generally of African descent and are adolescents or young adults at presentation. Both metabolic and traumatic etiologies have been proposed. We report six adult Caucasian patients with lesions that pathologically resembled tumoral calcinosis. All lesions were small (less than 3 x 3 cm) and were located along the proximal 1inca aspera of the femur. All patients presented with pain. Because of the atypical patient population and the unusual size and location of the lesions, we refer to this process as a "tumoral calcinosis-like lesion." A typical radiographic appearance and location, together with appropriate clinical history, can strongly suggest this diagnosis.

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Section: Discussionmentioning

confidence: 99%

Tumoral calcinosis-like lesion of the proximal linea aspera

et al. 1990

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“…By only the fourth month of therapy the patient experienced a marked reduction of the periarticular calcinosis and resolution of pain. This was significantly faster than the 8-10 months reported using only a glucocorticoid and aluminum hydroxide [5,45], Although combination therapy prevents a proper identifi cation of the most effective drug, the reduction in calcino sis was most likely due to the use of aluminum hydroxide and bisphosphonate. Even though the 25-hydroxyvitamin D levels were in the upper limits of normal after 4 months of therapy, initial attempts to discontinue prednisone resulted in hypercalcemia.…”

Section: Treatment O F Vitamin D Intoxicationmentioning

confidence: 68%

“…Large doses of aluminum-hydroxide-containing antacids have been used successfully to maintain phosphorus de privation and decrease the calcified masses in a patient with tumoral calcinosis [45] and calcinosis in renal failure patients [5].…”

Section: Treatment O F Vitamin D Intoxicationmentioning

confidence: 99%

Calcinosis and Metastatic Calcification due to Vitamin D Intoxication

Allen¹,

Shah²

1992

Horm Res

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Vitamin D, a fat-soluble vitamin, can be associated with significant morbidity when prescribed in large doses. We describe a hypoparathyroid patient with vitamin D intoxication who developed painful periarticular calcinosis, nephrocalcinosis with hypertension and chronic renal failure in addition to band keratopathy and hearing loss. He was treated with combination therapy including prednisone, phosphate-binding antacid, phenytoin and disodium etidronate. After 20 months of follow-up there was a significant reduction of periarticular calcinosis, but no improvement in renal function, band keratopathy or hearing loss and possible calcification of the ossicles. The clinicopathologic features of metastatic calcification and the various treatment modalities are reviewed.

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“…10 There is no evidence to infer that such treatment causes demineralisation of normal bone. 11 The most effective treatment is a combination of surgical excision, phosphate deprivation, and use of acetazolamide. 12,13 …”

Section: Treatmentmentioning

confidence: 99%

Tumoral Calcinosis: A Case Report

Leung

Lai

2011

J Orthop Surg (Hong Kong)

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An 11-year-old girl presented with a progressive swelling of the right elbow after a contusion. Radiography and magnetic resonance imaging showed a densely calcified lesion with no periosteal reaction or fracture. The underlying bone and muscles had normal signal intensity. A bone scan revealed increased uptake over the right elbow and the left buttock and acetabulum. Blood tests revealed no abnormality. As the mass progressively increased in size and malignancy could not be excluded, excision was performed 4 months after presentation. A lobulated, yellowish mass with a pseudo-capsule measuring 9x7x4 cm was excised. It was not attached to surrounding muscles, and some chalky, well-defined material emerged from the surface. Histological findings confirmed the diagnosis of tumoral calcinosis. The mass was transversed by fibrous septa with fibroblastic proliferation. Foreign body giant cells and histiocytic cells were found within the septa. There was no evidence of malignancy. Four months later, excision of the left elbow and buttock lesions was performed, and histology of both revealed the same diagnosis. At the 4-year follow-up, there was no recurrence.

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Treatment of Tumoral Calcinosis with Phosphorus Deprivation

Cited by 92 publications

References 15 publications

Tumoral calcinosis-like lesion of the proximal linea aspera

Tumoral calcinosis-like lesion of the proximal linea aspera

Calcinosis and Metastatic Calcification due to Vitamin D Intoxication

Tumoral Calcinosis: A Case Report

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