Treatment of Ulcers on the Legs With Hyperbaric Oxygen

Fischer, Boguslav H.

doi:10.1111/j.1524-4725.1975.tb00098.x

Cited by 25 publications

(11 citation statements)

References 2 publications

(3 reference statements)

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“…In 1969, Fisher introduced the topical HBO treatment with a small chamber for an open wound on the lower leg extremity for 2 -3 h twice a day and achieved good results [10,11]. Ravina et al reported a simple, disposable, hyperbaric oxygen device with a polyethylene bag for the treatment of wounds [12].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of topical hyperbaric oxygen for refractory foot ulcer

Ishii

Ushida

Tateishi

et al. 2004

Materials Science and Engineering: C

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Section: Discussionmentioning

confidence: 99%

Efficacy of topical hyperbaric oxygen for refractory foot ulcer

Ishii

Ushida

Tateishi

et al. 2004

Materials Science and Engineering: C

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“…A large number of observational studies reported successful results with TOT. [21][22][23][24] In a recent observational case series study, Gordillo et al, reported promising results with TOT in patients with non-healing chronic wounds who achieved good wound healing, an observation which was confirmed by a significant increase in VEGF expression on biopsy samples obtained from the edge of the wounds. 25 In a more recent non-randomized controlled study conducted by Blackman et al on 28 patients with diabetic foot ulcers (DFUs), the mean healing duration was shown to be significantly shorter with TOT as compared with standard wound care [56 days in 14 of the 17 (82.4%) patients vs. 93 days in 5 of the 11 patients (45.5%)].…”

Section: Introductionmentioning

confidence: 99%

Topical Oxygen for Chronic Wounds: A PRO/CON Debate

Mutluoğlu

Cakkalkurt

Uzun³

et al. 2013

Journal of the American College of Clinical Wound Specialists

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The role of oxygen in wound healing is universally accepted and does not require any further evidence; however the controversy as to whether oxygen delivery systems have the potential to improve wound healing remains to be concluded. Topical oxygen treatment (TOT) involves the delivery of 100% oxygen for a mean of 90 min, once a day at an atmospheric pressure slightly above 1 atm abs. The use of TOT gained increasing interest recently. The current manuscript will summarize the pros and cons of TOT in the view of the available literature.

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“…Fisher (3,4) and others (5)(6)(7) have reported marked acceleration of wound healing in patients with leg and foot ulcers of various etiologies (including diabetes mellitus) as a result of treatment with topical hyperbaric oxygen (THO). However, because these studies were retrospective and uncontrolled (3)(4)(5)(6) or the assignment of subjects to oxygen versus control therapy was apparently arbitrary (7), the validity of their conclusions is subject to scientific criticism.…”

mentioning

confidence: 99%

Randomized Controlled Trial of Topical Hyperbaric Oxygen for Treatment of Diabetic Foot Ulcers

et al. 1988

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The effect of 2 wk of topical hyperbaric oxygen (THO) treatment on the healing of diabetic foot ulcers without associated gangrene was evaluated in a prospective, controlled, and randomized manner in 28 patients. There were 12 patients in the THO group (group 1) and 16 in the control group (group 2). Clinical management of the two patient groups was similar except for THO treatment in the group 1 patients. Clinical parameters, including age, sex, baseline fasting serum glucose levels, duration of diabetes mellitus, duration of foot ulcers, presence of peripheral neuropathy or arterial insufficiency, and evidence of osteomyelitis as determined by radiographs and/or radionuclide scans, were comparable in both groups of patients. No statistical differences (Student's t test) were seen in the number of microorganisms isolated from curettage cultures of the base of the ulcer at days 0, 7, and 14 of the study between groups 1 and 2. In contrast to previous studies, there was a paucity of anaerobic microorganisms isolated from these foot ulcers without associated gangrenous changes. Ulcer areas were estimated by multiplying the maximum width by the maximum length in millimeters at days 0, 7, and 14. Analysis of variance and Student's t test revealed progressive significant reductions in the ulcer areas in both groups when days 0, 7, and 14 were compared and in ulcer depths in both groups when days 0 and 14 were compared. However, such ulcer size changes did not differ statistically between the control and THO groups. A trend toward slower healing was observed in the THO group. Healing of diabetic foot ulcers was not accelerated by THO in this study.

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Treatment of Ulcers on the Legs With Hyperbaric Oxygen

Abstract: Skin ulcerations present in patients being treated for other conditions with hyperbaric oxygen were noted to heal at an accelerated rate. This observation led to the concept of topical exposure to hyperbaric oxygen as a treatment of intractable cutaneous ulcers.

Cited by 25 publications

References 2 publications

Efficacy of topical hyperbaric oxygen for refractory foot ulcer

Efficacy of topical hyperbaric oxygen for refractory foot ulcer

Topical Oxygen for Chronic Wounds: A PRO/CON Debate

Randomized Controlled Trial of Topical Hyperbaric Oxygen for Treatment of Diabetic Foot Ulcers

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