Treatment of Unresectable Differentiated Thyroid Carcinoma With Upfront External Radiotherapy and Salvage Surgery: A STROBE-Compliant Retrospective Cohort Study

Carrillo, José F.; Flores, Jesús Manuel; Espinoza, Gilberto; Vázquez-Romo, Rafael; Ramírez-Ortega, Margarita; Carrillo, Liliana C.; Cortés-García, Beatriz Y.; Ochoa‐Carrillo, Francisco Javier; Oñate‐Ocaña, Luis F.

doi:10.3389/fonc.2020.572958

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…Finally, the role of adjuvant cervical EBRT remains controversial [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Although this study includes the course of seven patients receiving adjuvant EBRT, only two (28.6%) of them took benefit of treatment in terms of cervical clearance of disease.…”

Section: Discussionmentioning

confidence: 99%

Radioiodine Refractory Follicular Thyroid Cancer and Surgery for Cervical Relapse

Chiapponi

Hartmann

Schmidt

et al. 2021

Cancers

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Compared to its more common counterpart papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) has a less favorable outcome, due to its higher incidence of distant metastases and advanced stages at diagnosis. Despite radioiodine (RAI) avidity, metastatic FTC often progresses after radioiodine treatment (RAIT). We aimed at evaluating the indications and outcomes of surgery for cervical relapse of radioiodine refractory FTC. Patients receiving RAIT between 2005 and 2015 at the University Hospital of Cologne, Germany, were screened. Patients with FTC were identified. Demographics, clinic-pathologic characteristics, treatment, and outcome of patients diagnosed with RAI refractory FTC, who underwent cervical surgery in the course of disease, were analyzed. FTC accounted for 8.8% of all thyroid carcinomas undergoing RAIT. In 35.2% of FTC patients, disease persisted or recurred despite a cumulative mean RAI activity of 18.7 GBq ± 11.6 (follow-up 83.5 ± 56.7 months). Distant metastases were diagnosed in 75% of these patients, as bone (57.6%), lung (54.6%), and liver metastases (12.1%). Cervical relapse occurred in 63.6% of these patients and was treated in 57.1% with surgery with, and without, external beam radiation therapy (EBRT). Despite surgery and EBRT, in 75% of patients, cervical relapse recurred again. In conclusion, surgery for cervical radioiodine refractory FTC relapse is often performed in metastatic setting. With and without EBRT, cure is rare, although metastases can appear radioiodine avid. Early biological marker and systemic treatments for these patients are still needed.

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Section: Discussionmentioning

confidence: 99%

Radioiodine Refractory Follicular Thyroid Cancer and Surgery for Cervical Relapse

Chiapponi

Hartmann

Schmidt

et al. 2021

Cancers

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“…Patients with ECOG performance status≤2 received doses above 56 Gy and a palliative dose of 30-50 Gy was used for patients with poor performance status. IMRT followed by salvage surgery was associated with increased Progression Free Survival and Overall Survival [16].…”

Section: Un-resectable Dtcmentioning

confidence: 97%

External Beam Radiotherapy in Differentiated Thyroid Cancer

Nair¹,

Ravikumar²,

Rafi³

et al. 2023

Thyroid Cancer - The Road From Genes to Successful Treatment

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Differentiated thyroid cancer is treated by surgery, radioiodine treatment, and Thyroid Stimulating Hormone (TSH) suppression. The role of external beam radiotherapy is mainly palliation of radio-iodine non avid metastatic lesions and in inoperable tumors. Metastasis involving weight-bearing bones and vertebral metastasis with impending spinal cord compression are primarily treated by external radiation. External Beam Radiotherapy improves loco-regional control in patients with gross residual disease after surgical resection. Patients with extra-thyroidal disease and positive margins are treated by adjuvant external beam radiotherapy, especially when the post op radio-iodine scan is negative. External beam radiotherapy is the treatment of choice for radio-iodine non avid inoperable loco-regional recurrence. SRS alone or surgery followed by SRS is the preferred treatment for solitary brain metastasis. Whole brain radiotherapy is the treatment of choice for multiple brain metastatic disease.

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“…Finally, Zhou et al highlight that radiotherapy plus chemotherapy contributes to prolonged overall survival and cancer specific survival compared with radiotherapy alone in anaplastic thyroid cancer patients, regardless of surgical resection and distant metastasis, reinforcing the new concepts explored by Wang and Zaffereo and their group on targeted agents ( 5 ). In the same venue to explore the role of radiotherapy in thyroid carcinoma, recent reports on the use of upfront radiation treatment followed by rescue surgery have appeared ( 6 ), which in combination with new targeted therapies could constitute a new approach for unresectable malignancies.…”

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confidence: 99%

Editorial: New strategies in treatment of differentiated thyroid carcinoma

et al. 2022

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Thyroid carcinoma, treatment strategies in thyroid cancer, thyroid cancer surgery, thyroid cancer diagnosis, thyroid cancer biomarkers, radionuclide I 131, thyroid cancer radiotherapy, thyroid cancer targeted therapy Editorial on the Research Topic New strategies in the treatment of thyroid carcinomaIn this Research Topic of manuscripts on New Strategies In Treatment of Thyroid Carcinoma (TC), edited by the journal Frontiers in Endocrinology, papers have been gathered that, from the perspective of basic sciences, can potentially contribute to provide issues for a better understanding of clinical problems.Moreover, molecular biology and studies designed to improve the intrinsic behavior of papillary carcinoma are pivotal in the development of targeted therapies. The study by Yang el al. tries to ellucidate the role of estrogen receptors on the stimulation of cancer cells, through a significant decrease on the levels of endogenous PPARg ligands PGJ2 and 15(S)-HETE. These findings open a venue to development of endogenous ligands PGJ2 and 15(S)-HETE, to treat papillary thyroid cancer.The role of primary cilia alterations in differentiated TC and its absence in the anaplastic variety is described, as well as its relationship to the presence of the Aurore kinase protein, which is linked to disassembly of these cilia in TC. The article by Ma et al. describes these phenomenae, as well as the possibility of other biochemical pathways implicated with these organelles like Nek1 and Plk1, with the possibility of developing drugs which could restore the physiology of primary cilia of thyroid cells like U0126 and ganetespib.TC has increased its incidence and prevalence during the last 20 years. This is secondary to a better understanding of its presentation, as well as of diagnostic studies performed at present, from which, different image tests like high definition ultrasound, CT scan and aspiration biopsy represent the most relevant ones.On the other hand, a significant number of reports attest to efforts to improve the diagnosis potential of the aforementioned tests. In this e-book the report by Zhang et al., establishes the modification of plasma N-glycome alteration in Thyroid Carcinoma and Frontiers in Endocrinology frontiersin.org 01

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Treatment of Unresectable Differentiated Thyroid Carcinoma With Upfront External Radiotherapy and Salvage Surgery: A STROBE-Compliant Retrospective Cohort Study

Cited by 7 publications

References 22 publications

Radioiodine Refractory Follicular Thyroid Cancer and Surgery for Cervical Relapse

Radioiodine Refractory Follicular Thyroid Cancer and Surgery for Cervical Relapse

External Beam Radiotherapy in Differentiated Thyroid Cancer

Editorial: New strategies in treatment of differentiated thyroid carcinoma

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