Treatment of Unresectable Hepatocellular Carcinoma with Use of 90Y Microspheres (TheraSphere): Safety, Tumor Response, and Survival

Salem, Riad; Lewandowski, Robert J.; Atassi, Bassel; Gordon, Stuart C.; Gates, Vanessa L.; Barakat, Omar; Sergie, Ziad; Wong, Ching Yee Oliver; Thurston, Kenneth G.

doi:10.1097/01.rvi.0000184594.01661.81

Cited by 375 publications

(202 citation statements)

References 36 publications

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“…13), 14) For the thermal coagulation therapy, the magnetic materials containing glass ceramics have been studied for the embolization method. Fe 3 O 4 microspheres with a 20 30¯m diameter range were synthesized by melting the powder in a high frequency induction thermal plasma at high temperature and by precipitation from an aqueous solution.…”

Section: )mentioning

confidence: 99%

Development of nano-sized superparamagnetic ferrites having heat generation ability in an AC magnetic field for thermal coagulation therapy

Aono

2014

J. Ceram. Soc. Japan

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Thermal coagulation therapy using powdered magnetic materials in an alternating (AC) magnetic field has been expected as a treatment of cancerous tissues. For nano-sized superparamagnetic particles, the magnetic energy is mainly converted to a heat generation ability by the rotation of the magnetic moment (Néel relaxation) along with the rotation of the particles (Brownian relaxation). Fe 3 O 4 (magnetite) nanoparticles have been mainly investigated as the candidate material for this type of therapy. In this review, an outline of the ferrite materials having heat generation ability in the AC magnetic field is described for the application of the thermal coagulation therapy. In particular, I focused on the preparation of a nano-sized magnetic material using physical bead milling to develop a magnetic material of Y 3 Fe 5 O 12 and its high heat generation ability. The preparation of Y 3 Fe 5 O 12 microspheres with a 2032¯m diameter range using the bead-milled powder was also described for the embolization method of cancer treatment.

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Section: )mentioning

confidence: 99%

Development of nano-sized superparamagnetic ferrites having heat generation ability in an AC magnetic field for thermal coagulation therapy

Aono

2014

J. Ceram. Soc. Japan

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“…Yttrium-90 microspherers using TheraSphere µ and SIR-Sphere µ have already been used for the radioembolization of liver tumors. 16), 17) In the case of thermal coagulation therapy, magnetic materials containing glass ceramics have been studied for the embolization method. Kawashita et al reported the synthesis of FeFe 2 O 4 microspheres with a 2030¯m diameter range prepared by melting the powder in a high frequency induction thermal plasma and by precipitation from an aqueous solution.…”

Section: )13)mentioning

confidence: 99%

Preparation of MgFe2O4 microsphere using spray dryer for embolization therapy application

Aono

Naohara

Maehara

et al. 2010

J. Ceram. Soc. Japan

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MgFe 2 O 4 microspheres having a 2032 µm diameter range were prepared by a spray dryer using bead-milled nano-sized particles. A commercial powder having a several µm particle size was bead-milled to an approximate 6.2 nm crystallite size. The microspheres were obtained using the spray dryer when the air pressure was low (0.03 MPa). The yield of the MgFe 2 O 4 2032 µm microspheres was improved by combination of a low air pressure and high ferrite concentration in the slurry. The heat generation ability in an AC magnetic field (370 kHz, 1.77 kA/m) was improved by the bead milling.

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“…Y-90 labeled microsphere radioembolization can provide a safe and effective therapeutic method for both hepatocellular carcinoma and metastatic hepatic tumor [6,[12][13][14][15][16]. In the randomized trial by Hazel et al [12], among patients with hepatic metastasis of colorectal cancer, the group treated with combination regimen of cheomotherapy plus single Y-90 microsphere administration demonstrated significantly increased therapeutic response and survival than the chemotherapy-only control group.…”

Section: Introductionmentioning

confidence: 99%

“…Many hepatic malignant tumors cannot be surgically resected because they are locally advanced or involving both hepatic lobes at the time of diagnosis. A variety of therapeutic methods have been introduced for unresectable hepatic tumors, such as systemic chemotherapy, external radiation therapy, trans-arterial chemoembolization, percutaneous ethanol injection, and percutaneous radiofrequency ablation [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Usefulness of Bremsstrahlung Images after Intra-arterial Y-90 Resin Microphere Radioembolization for Hepatic Tumors

Kim

et al. 2010

Nucl Med Mol Imaging

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Purpose Y-90 resin microsphere radioembolization is used to treat inoperable hepatic tumors. After injection of Y-90 resin microsphere, the only method to visualize the distribution of Y-90 is the scintigraphic imaging of bremsstrahlung radiation. The purpose of this study was to evaluate the characteristics and usefulness of bremsstrahlung imaging in Y-90 resin microsphere treatment. Methods Twenty patients (22 administrations) underwent intra-arterial Y-90 resin microsphere treatment. For pretreatment planning, images of Tc-99m albumin macroaggregate (MAA) arterial injection and hepatic contrast angiography were obtained. Post-treatment bremsstrahlung images were taken and compared with pre-treatment images. The extrahepatic activity was evaluated on bremsstrahlung images. To correlate the size and vascularity of the tumors with tumor visualization on bremsstrahlung images, the individual tumors were grouped according to visualization on each image and compared with one another by size and tumor-to-normal ratio. Results All post-therapeutic bremsstrahlung images showed similar contours of the liver with pre-treatment angiography. No extrahepatic activity was seen in all cases. The visualized tumors on bremsstrahlung images were significantly larger than the non-visualized tumors. Tumor-to-normal ratios of the visualized tumors on bremsstrahlung images were significantly higher than those of the non-visualized tumors. Conclusions Bremsstrahlung images after intra-arterial Y-90 resin microsphere treatment are useful in evaluating the intrahepatic distribution of radioisotope and detecting possible extrahepatic activity.

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Treatment of Unresectable Hepatocellular Carcinoma with Use of 90Y Microspheres (TheraSphere): Safety, Tumor Response, and Survival

Cited by 375 publications

References 36 publications

Development of nano-sized superparamagnetic ferrites having heat generation ability in an AC magnetic field for thermal coagulation therapy

Development of nano-sized superparamagnetic ferrites having heat generation ability in an AC magnetic field for thermal coagulation therapy

Preparation of MgFe2O4 microsphere using spray dryer for embolization therapy application

Usefulness of Bremsstrahlung Images after Intra-arterial Y-90 Resin Microphere Radioembolization for Hepatic Tumors

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