Treatment of Vitiligo With the 308-nm Xenon Chloride Excimer Laser

Evaluation of a novel 308-nm monochromatic excimer light delivery system in dermatology: a pilot study in different chronic localized dermatoses

“…Previous studies using the 308-nm excimer laser have demonstrated its efficacy in localized plaque-type psoriasis 2-6 and in vitiligo. [7][8][9] Various protocols have been used, but all the authors demonstrated successful clearing of dermatoses in fewer overall treatments with a much lower cumulative UVB dose. As little as one single high-dose (8-16 MED) excimer laser treatment can be effective for localized plaque-type psoriasis.…”

Short-term Effects of 308-nm Xenon-chloride Excimer Laser and Narrow-band Ultraviolet B in the Treatment of Vitiligo: A Comparative Study

“…This permits the variation of some important phototherapeutic parameters, such as impulse frequency and intensity. It has been suggested that these optical properties of the excimer laser should make it more effective than NBUVB in the treatment of vitiligo (9). …”

Stable Vitiligo Treated by a Combination of Low-Dose Oral Pulse Betamethasone and Autologous, Noncultured Melanocyte-Keratinocyte Cell Transplantation

“…Various most widely accepted nonsurgical treatment modalities include topical steroids, Narrow Band UVB, 3 and a 308 nm excimer laser. 4,5 The degree of repigmentation that defines the success has been set somewhat arbitrarily at 50 to 75% repigmentation based on the global impression of the overall response. 3 The period required to achieve this degree of success may range from months to years.…”

“…3 Recently xenon chloride (XeCl) excimer laser-generated 308 nm UVB radiation has been proposed as a targeted phototherapy to vitiligo lesions. 4,5 Based on the autoimmune etiologic theory of vitiligo, the use of oral corticosteroids to suppress the disease is justified. Recently oral pulse betamethasone 6 and dexamethasone 7 have been used effectively in doses of 10 to 20 mg/week to treat active and stable vitiligo.…”