Treatment options for malignant hemangioendotheliomas of the thyroid

Rhomberg, Walter; Boehler, Franz; Eiter, Helmut; Fritzsche, H; Breitfellner, G

doi:10.1016/j.ijrobp.2004.03.023

Cited by 17 publications

(9 citation statements)

References 12 publications

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“…28 Thyroid HAS is usually regarded as an extremely aggressive neoplasm with a dismal prognosis, similar to anaplastic carcinoma. However, our cases, as well as those reported by certain other authors, 3,12 show that HAS can behave in a less aggressive way, particularly if there is no extrathyroidal spread of the tumour at the time of operation. 19 Of course, the number of cases in the present series is too small to allow us to draw any definitive prognostic conclusions about this tumour entity and further studies are needed.…”

Section: Discussionsupporting

confidence: 86%

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Epithelioid haemangiosarcoma of the thyroid gland. Report of six cases from a non‐Alpine region

et al. 2004

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Section: Discussionsupporting

confidence: 86%

“…Haemangiosarcoma (HAS), or malignant haemangioendothelioma, has been classically described in Alpine regions, namely in Switzerland, Austria and northern Italy, 1–6 representing 2–10% of all thyroid malignancies in different series 1,7–9 . In other areas it is extremely rare with only sporadic cases being reported 10–13 .…”

Section: Introductionmentioning

confidence: 99%

Epithelioid haemangiosarcoma of the thyroid gland. Report of six cases from a non‐Alpine region

et al. 2004

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“…While aggressive surgical resection to achieve local control of cancer remains the cornerstone of primary treatment [3], most patients develop postoperative early systemic metastasis; this observation leads to the hypothesis that undetected systemic micrometastases are present at the time of diagnosis. So the proposal to use adjuvant chemotherapy for systemic control and radiotherapy for local control in the treatment of angiosarcoma has been widely accepted [3,4,7,9]. In spite of chemotherapy the present patient did not get much benefit from this therapy.…”

Section: Discussionmentioning

confidence: 71%

A Case of Hemangiosarcoma in Thyroid with Severe Anemia due to Bone Marrow Metastasis

et al. 2005

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Abstract.A 56-year-old woman presented with rapidly enlarging thyroid mass and deep anemia. There was no history of gastrointestinal bleeding, and endoscopic examinations of the gastrointestinal system were normal. Fine needle aspiration cytology from the thyroid nodule was suspicious. After blood transfusion, total thyroidectomy was performed. Postoperative histopathological examination of the specimen revealed hemangiosarcoma of the thyroid. After establishment of the diagnosis chemotherapy was started. But hemoglobin values decreased again and hepatosplenomegaly developed at the second month of surgery. Bone marrow aspiration cytology which was performed demonstrated the same tumoral cells infiltrating bone marrow. The patient died at 12th week after surgery. Thyroid hemangiosarcoma can metastasize to the bone marrow and anemia may be an indicator of the advanced disease. In the differential diagnosis of the anemia, bone marrow metastasis and bone marrow biopsy should be considered in suspected cases.

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“…Most European authors think that these lesions represent true vascular neoplasms. 6,8,9,14,15,17,20,22,23,25 Authors who accept the vascular nature of these specimens base their assertion on the factor VIII immunoreactivity of the neoplastic cells. 21,28,29 The vascular nature has been corroborated by several ultrastructural studies that have supported an endothelial origin.…”

Section: Discussionmentioning

confidence: 99%