Treatment outcome in patients with presumed tubercular uveitis at a tertiary referral eye care centre in Singapore

Ang, Leslie; Kee, Aera; Yeo, Tun Hang; Dinesh, V.; Ho, Su Ling; Teoh, Stephen C.; Agrawal, Rupesh

doi:10.1007/s10792-016-0401-6

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…We found the same results when selecting only the cases of tubercular panuveitis. These findings are the opposite of the conclusion of Ang et al 31 In their study, 36 out of 53 patients received ATT, and ATT was combined with systemic steroids in 28 of these patients. None of the patients received intravitreal or periocular steroids.…”

Section: Time (Months)contrasting

confidence: 72%

Uveitis associated with latent tuberculosis: A comparative study of the impact of antitubercular therapy combined or not with systemic corticosteroids

Nahon-Estève

Martel

Maschi

et al. 2020

European Journal of Ophthalmology

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Purpose: To study the outcome of latent tubercular uveitis (LTBU) treated with antitubercular therapy (ATT) combined or not with adjuvant systemic corticosteroids. Methods: Twenty patients (27 eyes) with LTBU were included in a monocentric retrospective study and evaluated for the absence of active disease after treatment. Data on the clinical outcomes (active inflammation), vision (best-corrected visual acuity, BCVA) and treatment were collected retrospectively. Results: Fourteen patients received ATT alone and six patients received ATT combined with systemic corticosteroids. The two groups were not comparable in terms of proportion of tubercular panuveitis cases and initial BCVA (59.3 ± 8.2 letters vs 44.2 ± 15.2 letters). There was no significant difference in remission rate and in BCVA between both groups 3 months after ATT discontinuation. Conclusion: Patients with LTBU treated with ATT alone had visual and inflammatory outcomes at least comparable to those of patients treated with ATT combined with systemic corticosteroids.

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Section: Time (Months)contrasting

confidence: 72%

Uveitis associated with latent tuberculosis: A comparative study of the impact of antitubercular therapy combined or not with systemic corticosteroids

Nahon-Estève

Martel

Maschi

et al. 2020

European Journal of Ophthalmology

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“…Variable rates of ocular findings and complications have been reported in literature from individual centers, ranging from 9% to 45% for choroiditis, 4% to 61% for retinal vasculitis, 8% to 67% for vitritis, 7.5% to 45% for cystoid macular edema, 26% to 51% for optic disc involvement, 6% to 33% for snowball and 4% to 8% for snowbanking. [14][15][16][17][18][19][20][21][22]…”

Section: Clinical Featuresmentioning

confidence: 99%

Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1

Testi

Agrawal

Mahajan

et al. 2019

Ocular Immunology and Inflammation

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“…According to these studies, the proportion of successful outcomes in patients who undergo ATT is greater than in patients who do not. 6,20,26–28 In our cohort, most patients had treatment success. When analyzing patients who experienced recurrences, we still found a reduction in the number of recurrences following ATT.…”

Section: Discussionmentioning

confidence: 74%

“…25 Many authors suggest prolonged anti-mycobacterial therapy for OTB because it is associated with a significant reduction in inflammation recurrence and treatment failure. 6,[25][26][27] Given the strong medical evidence supporting more extended treatment, the majority of patients in our cohort were treated for 9 months or more.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and management of presumed ocular tuberculosis: A long-term follow-up cohort study in a tertiary referral center in Brazil

Zamora

Finamor

Silva

et al. 2021

European Journal of Ophthalmology

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Purpose: To evaluate the clinical features and management of presumed ocular tuberculosis (OTB). Method: A prospective 3-year follow-up study of patients with ocular inflammation that performed Interferon-gamma release assay (IGRA) and tuberculin skin test (TST) was conducted in a tertiary referral center in Brazil. Patients with clinical signs highly suspect of OTB with a positive TST and/or IGRA with other causes ruled out were prescribed anti-tuberculosis therapy (ATT) during 9 months. Clinical features and treatment outcomes were recorded. Results: Seventy-two patients (mean age 48.3 ± 15.7 years) were included in the study, and most were female (65.3%, n = 47). Posterior uveitis (43.1%, n = 31) was the main clinical feature. Multifocal choroiditis (25%, n = 18) was the most common choroidal involvement. Concomitant oral prednisone (45.8%, n = 33) during ATT was associated with more recurrences ( p = 0.04). A significant difference ( p < 0.001) between initial and final best-corrected visual acuity after ATT conclusion was observed. Cure or remission was observed in 58 (85.3%) patients that completed follow-up ( n = 68). Conclusion: In our cohort some variation in demographics and ocular phenotypes of presumed OTB was observed. The high rates of cure or remission of our patients strongly support the ATT in presumed OTB. Oral corticosteroids during ATT were associated with higher recurrences rates.

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Treatment outcome in patients with presumed tubercular uveitis at a tertiary referral eye care centre in Singapore

Abstract: The use of ATT, with or without concurrent corticosteroid, may not have a statistically significant impact in improving treatment success in patients with presumed TBU.

Cited by 7 publications

References 25 publications

Uveitis associated with latent tuberculosis: A comparative study of the impact of antitubercular therapy combined or not with systemic corticosteroids

Uveitis associated with latent tuberculosis: A comparative study of the impact of antitubercular therapy combined or not with systemic corticosteroids

Tubercular Uveitis: Nuggets from Collaborative Ocular Tuberculosis Study (COTS)-1

Clinical features and management of presumed ocular tuberculosis: A long-term follow-up cohort study in a tertiary referral center in Brazil

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