Treatment outcome of childhood nasopharyngeal carcinoma: A single institution experience

Nikitović, Marina; Popovic-Vukovic, Marija; Stanić, Dragana; Bokun, Jelena; Paripovic, Lejla; Ilić, Vesna; Mišković, Ivana; Sarić, Milan

doi:10.1016/j.ijporl.2018.07.031

Cited by 11 publications

(7 citation statements)

References 45 publications

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“…We have shown that IMRT resulted in a favorable prognosis for children and adolescent NPC (5-year DFS, 81.5%), especially in patients with low pretreatment EBV DNA load (5-year DFS, 86.9%), which indicated that pretreatment EBV DNA level is an important prognostic factor in this age group. In young patients, the predominant histology of NPC is an undifferentiated variant of disease (27)(28)(29), which was confirmed in our study where 98.0% of pediatric patients were histologically WHO type III. On the other hand, ∼96.0% of our patients presented in advanced clinical stage III or IV, similar to other reports with stage III-IV patients accounting for 92.0-97.3% (5,7,29).…”

Section: Discussionsupporting

confidence: 87%

Clinical Implications of Plasma Epstein–Barr Virus DNA in Children and Adolescent Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy

Qiu

Guo

et al. 2020

Front. Oncol.

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Section: Discussionsupporting

confidence: 87%

Clinical Implications of Plasma Epstein–Barr Virus DNA in Children and Adolescent Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy

Qiu

Guo

et al. 2020

Front. Oncol.

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“…A meta-analysis by Langendijk et al demonstrated that concurrent chemotherapy was associated with a pooled hazard ratio (HR) of 0.48 (95% CI, 0.32-0.72) which corresponded to a 20% improvement in five-year OS compared to RT alone while neoadjuvant chemotherapy was associated with improved locoregional control with a decreased rate of distant metastases [100]. Similar results have been documented throughout the literature [101][102][103][104][105]. Despite these advances, many patients continue to present with locoregional or systemic recurrence with most relapses occurring within the first two years (median 8 months) following treatment [98,106,107].…”

Section: Nasopharyngeal Carcinomamentioning

confidence: 57%

Pediatric Head and Neck Malignancies

Silverman¹,

Wanner²,

Walz³

et al. 2021

Surgical Management of Head and Neck Pathologies

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Head and neck malignancies are a part of the differential diagnosis of head and neck masses seen in the pediatric age group. It is critical to make prompt diagnosis and employ proper treatment. We will review the most common malignant pathologies as well as their specific clinical presentations and management. Centers that are able to provide multidisciplinary care for pediatric patients with head and neck pathology can help achieve the best outcomes.

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“…Radiation of 50 Gy is often desirable for neck nodes. The chemotherapy includes methotrexate, bleomycin, and cisplatin [17]. Nasopharyngeal carcinomas are more radiosensitive [18].…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal carcinoma among the pediatric patients in a non-endemic region: our experience at a tertiary care teaching hospital in Eastern India

Swain

Samal

Mohanty

et al. 2020

Egypt Pediatric Association Gaz

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Background: Nasopharyngeal carcinoma (NPC) is an extremely rare malignant lesion among the pediatric age group. The relative rarity of pediatric NPC makes the diagnosis difficult. This rarity is often associated with delayed diagnosis which may lead to advanced loco-regional disease. Here, we study the clinical presentations, investigations, and treatment of nasopharyngeal carcinoma in the pediatric age group in a non-endemic region. Result: This is a retrospective study where 21 pediatric patients were enrolled with age under 18 years. They were managed at a tertiary care teaching hospital between December 2010 and January 2019. Majority of the patients in this study were boys (66.7%). All children diagnosed with NPC were treated with radiotherapy covering entire nasopharynx and some children with chemotherapy. Until the patient is in a late stage, most children diagnosed with NPC were presenting with symptoms of neck mass (90.5%), bleeding from the nose (66.7%), nasal blockage (57.1%), and hearing loss (47.6%). Pathological report revealed WHO type III in the majority of the patients. All patients were treated with radiotherapy to primary and enlarged neck nodes. Conclusion: Children with NPC have excellent survival except for those with distant metastatic disease. NPC in the pediatric age is usually not suspected clinically until patient in late stage. The TNM staging has the most relevant prognostic factor. Unfortunately, NPC tends to be locally advanced at the time of diagnosis in the pediatric age group and is sometimes associated with distant metastasis. In our study, most children were diagnosed with NPC along with neck node enlargement and were treated with radiotherapy. The diagnosis of pediatric NPC should prompt timely treatment.

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Treatment outcome of childhood nasopharyngeal carcinoma: A single institution experience

Cited by 11 publications

References 45 publications

Clinical Implications of Plasma Epstein–Barr Virus DNA in Children and Adolescent Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy

Clinical Implications of Plasma Epstein–Barr Virus DNA in Children and Adolescent Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy

Pediatric Head and Neck Malignancies

Nasopharyngeal carcinoma among the pediatric patients in a non-endemic region: our experience at a tertiary care teaching hospital in Eastern India

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