Treatment Outcome of Mineral Trioxide Aggregate or Calcium Hydroxide Direct Pulp Capping: Long-term Results

Mente, Johannes; Hufnagel, Sarah; Leo, Meltem; Michel, Annemarie; Gehrig, Holger; Panagidis, Dimos; Saure, Daniel; Pfefferle, Thorsten

doi:10.1016/j.joen.2014.07.019

Cited by 171 publications

(191 citation statements)

References 36 publications

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“…2,3,4,5 This aggression may be enough to cause impaired regenerative potential and loss of pulp vitality, depending on the previous condition of the pulp tissue. 25,26 Moreover, the loss of progenitor cells during this process has an aging effect that may reduce the regenerative capability of the pulp to withstand future challenges. 6 Therefore, the development of biomaterials that facilitate pulp regeneration of the remaining vital pulp tissues is desired to promote dental pulp self-repair, and regenerate dentin on exposed pulp.…”

Section: Discussionmentioning

confidence: 99%

Chitosan-collagen biomembrane embedded with calcium-aluminate enhances dentinogenic potential of pulp cells

et al. 2016

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The development of biomaterials capable of driving dental pulp stem cell differentiation into odontoblast-like cells able to secrete reparative dentin is the goal of current conservative dentistry. In the present investigation, a biomembrane (BM) composed of a chitosan/collagen matrix embedded with calcium-aluminate microparticles was tested. The BM was produced by mixing collagen gel with a chitosan solution (2:1), and then adding bioactive calcium-aluminate cement as the mineral phase. An inert material (polystyrene) was used as the negative control. Human dental pulp cells were seeded onto the surface of certain materials, and the cytocompatibility was evaluated by cell proliferation and cell morphology, assessed after 1, 7, 14 and 28 days in culture. The odontoblastic differentiation was evaluated by measuring alkaline phosphatase (ALP) activity, total protein production, gene expression of DMP-1/DSPP and mineralized nodule deposition. The pulp cells were able to attach onto the BM surface and spread, displaying a faster proliferative rate at initial periods than that of the control cells. The BM also acted on the cells to induce more intense ALP activity, protein production at 14 days, and higher gene expression of DSPP and DMP-1 at 28 days, leading to the deposition of about five times more mineralized matrix than the cells in the control group. Therefore, the experimental biomembrane induced the differentiation of pulp cells into odontoblast-like cells featuring a highly secretory phenotype. This innovative bioactive material can drive other protocols for dental pulp exposure treatment by inducing the regeneration of dentin tissue mediated by resident cells.

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Section: Discussionmentioning

confidence: 99%

Chitosan-collagen biomembrane embedded with calcium-aluminate enhances dentinogenic potential of pulp cells

et al. 2016

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“…The clinical success rate of calcium hydroxide pastes for direct pulp capping over a 10-year period of time was reported to be 59.0% (59 teeth total). The failures included subsequent root canal treatment (15 teeth), pulp necrosis (1 tooth), asymptomatic apical periodontitis (2 teeth), clinical signs and symptoms (1 tooth), and extractions (5 teeth) 10) . Another clinical study showed that the success rate of direct pulp capping of 1,075 permanent teeth with calcium hydroxide was 80.1, 68.0 and 58.7% after 1, 5 and 9 years, respectively 11) .…”

Section: Calcium Hydroxide and Resin-modified Calcium Hydroxidementioning

confidence: 99%

“…The success rate of MTA (ProRoot) for direct pulp capping was reported to be 80.3% (195 cases) after 2 year-recall, which was higher than that of calcium hydroxide (Life, Kerr) (68.5%, 181 cases) 29) . Another clinical trial showed the overall success rate for MTA (ProRoot) was 80.5% (170 teeth total), with 33 failed teeth (19.5%) in 10 years 10) . The success rate was higher than that of calcium hydroxide (59%).…”

Section: Calcium Silicates and Resin-modified Calcium Silicatesmentioning

confidence: 99%

“…The success rate was higher than that of calcium hydroxide (59%). The failure included subsequent root canal treatment (25 teeth), pulp necrosis (2 teeth), asymptomatic apical periodontitis (4 teeth), and extraction (2 teeth) 10) . In another paper, 98% of teeth (49 teeth total) capped with MTA received favorable outcomes on the basis of radiographic appearance, subjective symptoms, and cold testing, over an observation period of nine years 3) .…”

Section: Calcium Silicates and Resin-modified Calcium Silicatesmentioning

confidence: 99%

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Cytotoxicity and biocompatibility of resin-free and resin-modified direct pulp capping materials: A state-of-the-art review

Chen¹,

Suh²

2017

Dental Materials Journal

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Direct pulp capping is the placement of a dental material directly over exposed pulp to prevent dental pulp from dying and avoid the need for root canal treatments. Calcium hydroxide and calcium silicates/mineral trioxide aggregates (MTA) have been commonly used for direct pulp capping with great success clinically. In recent years, resin-modified calcium hydroxide and calcium silicates have been developed with the advantages of precise placement, command set, and superior physical strength. As pulp capping materials would be in direct contact with the pulp, the cytotoxicity and biocompatibility is of particular importance in order to avoid pulp irritation and maintain pulp vitality. Therefore, this review article will summarize the cytotoxicity and biocompatibility of direct pulp capping materials, particularly resin-modified materials.

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“…Rates are more than 90% after 1 to 2 years and drop from 82% to 37% after 2 to 5 years 48) , or to 80%, 68% and 59% after 1, 5 and 9 years, respectively 49) . Although aqueous calcium hydroxide has been well-accepted clinically, it has drawbacks, including a lack of setting properties and gradual resorption after placement.…”

Section: Calcium Hydroxidementioning

confidence: 97%

Current status of direct pulp-capping materials for permanent teeth

Komabayashi

Zhu

Eberhart

et al. 2016

Dental Materials Journal

128

125

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Direct pulp-capping is a method for treating exposed vital pulp with dental material to facilitate the formation of reparative dentin and to maintain vital pulp. Two types of pulp-capping materials, calcium hydroxide and mineral trioxide aggregate, have been most commonly used in clinics, and an adhesive resin has been considered a promising capping material. However, until now, there has been no comprehensive review of these materials. Therefore, in this paper, the composition, working mechanisms and clinical outcome of these types of pulp-capping materials are reviewed.

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Treatment Outcome of Mineral Trioxide Aggregate or Calcium Hydroxide Direct Pulp Capping: Long-term Results

Cited by 171 publications

References 36 publications

Chitosan-collagen biomembrane embedded with calcium-aluminate enhances dentinogenic potential of pulp cells

Chitosan-collagen biomembrane embedded with calcium-aluminate enhances dentinogenic potential of pulp cells

Cytotoxicity and biocompatibility of resin-free and resin-modified direct pulp capping materials: A state-of-the-art review

Current status of direct pulp-capping materials for permanent teeth

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