Treatment outcome of patients with stages I–II nasopharyngeal carcinoma after late course accelerated hyperfractionation radiotherapy alone

He, Xianghuo; Yue, Ming; Guo, Xiaomao; Pan, Ziqiang; Zhang, Zhen; He, Shasha; Liu, Taifu

doi:10.1016/j.oraloncology.2012.05.008

Cited by 15 publications

(17 citation statements)

References 26 publications

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“…The upper limit was reported at 34 years, and the lower limit at 1 year . Case reports and case series examining radiation‐associated LCNP are summarized in Supporting Information Tables S1 and S2 . Incidence reports from cohort studies and latency data are summarized in Table and Supporting Information Tables S1 and S2, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Delayed lower cranial neuropathy after oropharyngeal intensity‐modulated radiotherapy: A cohort analysis and literature review

et al. 2017

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Background To examine swallowing-related lower cranial nerve palsy (LCNP) in oropharyngeal cancer (OPC) survivors after intensity modulated radiotherapy (IMRT). Methods Patients treated with definitive IMRT (66–72 Gy) were pooled from trial databases. Prospective analyses on parent trials included videofluoroscopy, clinical LCNP examination, and questionnaires pre- and 6-, 12-, and 24-months post-IMRT. Time-to-event and incidence of LCNP was estimated with competing risk methods. Literature review (1977–2015) summarized published LCNP outcomes. Results Three of 59 OPC survivors with a minimum 2-year follow-up developed hypoglossal palsy ipsilateral to the index tumor (median latency: 6.7 years, range: 4.6–7.6). At a median of 5.7 years, cumulative incidence of LCNP was 5%. LCNP preceded progressive dysphagia in all cases. Published studies found median incidence of radiation-associated LCNP was 10.5% after NPC, but no OPC-specific estimate. Conclusions While uncommon, the potential for late LCNP preceding swallowing deterioration highlights the importance of long-term functional surveillance in OPC survivorship.

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Section: Resultsmentioning

confidence: 99%

“…25 Case reports and case series examining radiation-associated LCNP are summarized in Supporting Information Tables S1 3,7,8,15,19-21,24-32 and S2. [3][4][5][6][7][8] Incidence reports from cohort studies and latency data are summarized in Table 3 33,34 and Supporting…”

Section: Literature Reviewmentioning

confidence: 99%

Delayed lower cranial neuropathy after oropharyngeal intensity‐modulated radiotherapy: A cohort analysis and literature review

et al. 2017

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“…Chua et al reported that the 5‐year OS rate was significantly higher in the chemotherapy combined with RT group (79%) than the RT‐alone group (67%). Recently, He et al also reported the outcome of early stages NPC treated by late course accelerated hyperfractionation RT alone and showed that the 5‐year OS was 83.4% and patients with N1 had a relatively lower survival rate, which suggested that chemotherapy might be indicated.…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes for early-stage nasopharyngeal carcinoma with predominantly WHO II histology treated by intensity-modulated radiation therapy with or without chemotherapy in nonendemic region of China

et al. 2013

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“…Treatment outcomes of Stage II NPC patients being treated with 2D-RT alone have been demonstrated to be far from satisfactory; most of them indicated that systemic treatment is needed because of the relatively high incidence of distant metastases and poor long-term survival after RT alone, and the addition of chemotherapy to RT may be translated into substantial improvements in long-term survival (4)(5)(6)(7)(8)(9)(10)(11). Data from the most recent publications have shown that intensity-modulated radiation therapy (IMRT) can greatly increase the treatment outcomes and improve the quality of life of NPC patients when compared with 2D-RT (12).…”

Section: Introductionmentioning

confidence: 99%

Long-term survival of nasopharyngeal carcinoma patients with Stage II in intensity-modulated radiation therapy era

Guo¹,

Lu²,

Shen³

et al. 2016

Jpn. J. Clin. Oncol.

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Objectives: To evaluate the long-term survival and the role of chemotherapy in nasopharyngeal carcinoma (NPC) patients in Stage II treated by intensity-modulated radiation therapy (IMRT). Methods: Three hundred and eleven NPC patients in Stage II were reviewed. All were treated with IMRT with or without chemotherapy, with 191, 20 and 100 patients being defined as T1N1M0, T2N0M0 and T2N1M0 stage, respectively. Results: At a median follow-up of 57 months, the 5-year overall survival, disease-specific survival, distant metastasis-free survival, loco-regional relapse-free survival (LRRFS) and progression-free survival were 91.1, 93.5, 90.6, 95.9 and 87.6%, respectively. T2N1 patients had significant poorer survival outcomes than T1N1 patients, with T2N0 patients in between. Further analysis showed that the addition of chemotherapy could only improve LRRFS [hazard ratio (HR) 0.263, 95% confidence interval (CI) 0.083-0.839, P = 0.024], especially for T1N1 patients (HR 0.209, 95% CI 0.046-0.954, P = 0.043). For those in the T2N1M0 group, chemotherapy, as used in our series, added no benefit to any endpoint. Conclusions: IMRT in NPC patients in Stage II was quite therapeutic; however, different subgroups have distinct survival outcomes. Distant metastasis was the main failure pattern, especially for those with T2N1 disease, and the chemotherapy currently in use failed to treat subclinical metastatic foci effectively. Further prospective study is warranted to find out the role and the optimal schedule of chemotherapy in this subgroup of patients.

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Treatment outcome of patients with stages I–II nasopharyngeal carcinoma after late course accelerated hyperfractionation radiotherapy alone

Cited by 15 publications

References 26 publications

Delayed lower cranial neuropathy after oropharyngeal intensity‐modulated radiotherapy: A cohort analysis and literature review

Delayed lower cranial neuropathy after oropharyngeal intensity‐modulated radiotherapy: A cohort analysis and literature review

Clinical outcomes for early-stage nasopharyngeal carcinoma with predominantly WHO II histology treated by intensity-modulated radiation therapy with or without chemotherapy in nonendemic region of China

Long-term survival of nasopharyngeal carcinoma patients with Stage II in intensity-modulated radiation therapy era

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