Treatment Outcomes in the Tube Versus Trabeculectomy (TVT) Study After Five Years of Follow-up

Gedde, Steven J.; Schiffman, Joyce C.; Feuer, William J.; Herndon, Leon W.; Brandt, James D.; Budenz, Donald L.

doi:10.1016/j.ajo.2011.10.026

Cited by 922 publications

(793 citation statements)

References 44 publications

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“…Secondary measures were reduction of medications and failure rates. Failure (using criteria of the Tube versus Trabeculectomy trial) [14] was defined as any one of IOP < 6, IOP > 21, or a smaller than 20% decrease from baseline at any two consecutive visits after the 90 day immediate postoperative period, or the need for a subsequent glaucoma procedure.…”

Section: Methodsmentioning

confidence: 99%

Longer-term Baerveldt to Trabectome glaucoma surgery comparison using propensity score matching

Kostanyan

Shazly

Kaplowitz

et al. 2017

Graefes Arch Clin Exp Ophthalmol

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1 AbstractPurpose: To apply propensity score matching to compare Baerveldt glaucoma drainage implants (BGI) to trabectome-mediated ab interno trabeculectomy (AIT). Recent data suggests that AIT can produce results similar to BGI which is traditionally reserved for more severe glaucoma.Methods: BGI and AIT patients with at least one year of follow-up were included. The primary outcome measures were intraocular pressure (IOP), number of glaucoma medications, and a Glaucoma Index (GI) score. GI reflected glaucoma severity based on visual field, the number of preoperative medications, and preoperative IOP. Score matching used a genetic algorithm consisting of age, gender, type of glaucoma, concurrent phacoemulsification, baseline number of medications, and baseline IOP. Patients with neovascular glaucoma, with prior glaucoma surgery or without a close match were excluded.Results: Of 353 patients, 30 AIT patients were matched to 29 BGI patients. Baseline characteristics including, IOP, the number of glaucoma medications, type of glaucoma , the degree of VF loss and GI were not significantly different between AIT and BGI. BGI had a preoperative IOP of 21.6±6.3 mmHg compared to 21.5±7.4 for AIT on 2.8±1.1 medications and 2.5±2.3, respectively. At 30 months, the mean IOP was 15.0±3.9 mmHg for AIT versus 15.0±5.7 mmHg for BGI (p>0.05), while the number of drops was 1.5±1.3 for AIT (change: p=0.001) versus 2.4±1.2 for BGI (change: p=0.17; AIT vs BGI: 0.007). Success, defined as IOP<21 mmHg, <20% reduction and no reoperation, was achieved at 1 year in 56% of AIT versus 55% of BGI (p>0.05) and 50% versus 52% at 2.5 years. Conclusions:A propensity score matched comparison of AIT and BGI demonstrated a similar IOP reduction through one year. AIT required fewer medications.2

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Section: Methodsmentioning

confidence: 99%

Longer-term Baerveldt to Trabectome glaucoma surgery comparison using propensity score matching

Kostanyan

Shazly

Kaplowitz

et al. 2017

Graefes Arch Clin Exp Ophthalmol

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“…Recent studies have demonstrated good short‐term results with early postoperative complication rates even lower than after trabeculectomy (Gedde et al. 2012a,b). …”

Section: Introductionmentioning

confidence: 99%

Corneal endothelial cell loss after Baerveldt glaucoma drainage device implantation in the anterior chamber

Tan

Webers

Berendschot

et al. 2016

Acta Ophthalmologica

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PurposeTo investigate central and peripheral corneal endothelial cell density (ECD) in relation to Baerveldt (BV) glaucoma drainage device (GDD) tube corneal (TC) distance.MethodsProspective study of all patients scheduled for glaucoma tube surgery with 36 months follow‐up. A BV GDD was inserted into the anterior chamber (AC). Anterior segment optical coherence tomography (AS‐OCT) scans were made to determine the TC distance. Central and peripheral ECD was measured, preoperatively and at 3, 6, 12, 24 and 36 months postoperatively.ResultsFifty‐three eyes were included [primary open‐angle glaucoma, (n = 13); secondary glaucoma, (n = 30); and primary angle‐closure glaucoma, (n = 10)]. Central ECD significantly decreased during follow‐up, with a mean decrease of 4.54% per year (p < 0.001), and 6.57% in the peripheral quadrant closest to the BV GDD tube (PQC, p < 0.001). In the PQC, a yearly decrease of 1.57% was shown after transiridial tube placement versus 7.43% after placement ‘free’ into the AC (p = 0.006). Endothelial cell (EC) loss was related to TC distance (mean 1.69 mm), with a central loss of 6.20% and 7.25% in the PQC per year with shorter TC distances, versus a central loss of 4.11% and 5.77% in the PQC per year with longer TC distances (outside mean ± 2SD, p < 0.001). A difference in EC loss by glaucoma subtype was not identified.ConclusionThe TC distance is of significant influence on corneal ECD, a shorter TC distance causing more severe EC loss, especially in the PQC. Transiridial placement of the BV GDD tube seems safer than placement ‘free’ into the AC.

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“…Reported percentages vary from 2.0%, 5.0% and 8.3% to 8.5% (Gedde et al. 2012a,b; Ng et al. 2015; Trubnik et al.…”

Section: Discussionmentioning

confidence: 99%

“…When comparing the number of tube exposures from our donor sclera cohort to the exposure rates reported in other studies using other patch graft materials, we observed a substantially lower rate (Gedde et al. 2012a,b; Trubnik et al. 2015).…”

Section: Discussionmentioning

confidence: 99%

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Donor sclera versus bovine pericardium as patch graft material in glaucoma implant surgery and the impact of a drainage suture

Wijsard

Haan

Rietveld

et al. 2018

Acta Ophthalmologica

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PurposeTo compare the use of human donor sclera with bovine pericardium as patch graft material for a glaucoma drainage device (GDD), with respect to the incidence of tube exposure, and to study the role of a drainage suture.MethodsAll GDD surgeries between 2010 and 2014 performed at the VU Medical Center were examined in this comparative, retrospective cohort study. A total of 244 cases were included; 163 in the human donor sclera cohort and 81 in the bovine pericardium cohort with a median follow‐up of 31 and 36 months, respectively. The primary outcome measure was occurrence of tube exposure. Survival analysis for tube exposure was carried out and Kaplan–Meier curves compared. Secondary outcomes were postoperative intraocular pressure (IOP), number of glaucoma medications and the effect of a drainage suture.ResultsIn the bovine pericardium cohort, eleven (13.6%) eyes developed tube exposure compared to none in the human donor sclera cohort. Their Kaplan–Meier survival curves differed significantly from each other (χ² = 21.1, p < 0.001, log‐rank test). Mean IOP and number of glaucoma medications did not differ significantly between patch graft materials at three months of follow‐up. The use of a drainage suture directly lowered IOP after surgery in both cohorts. Within the bovine pericardium cohort, eyes with a drainage suture experienced more tube exposure, although this difference was not statistically significant (p = 0.09).ConclusionHuman donor sclera leads to less tube exposure than bovine pericardium. A drainage suture directly lowers IOP after surgery. With bovine pericardium, but not with donor sclera, exposure tends to be enhanced by a drainage suture.

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Treatment Outcomes in the Tube Versus Trabeculectomy (TVT) Study After Five Years of Follow-up

Abstract: openAccessArticle: FalsePage Range: 789-789doi: 10.1016/j.ajo.2011.10.026Harvest Date: 2016-01-12 15:11:45issueName:cover date: 2012-05-01pubType: Original articl

Cited by 922 publications

References 44 publications

Longer-term Baerveldt to Trabectome glaucoma surgery comparison using propensity score matching

Longer-term Baerveldt to Trabectome glaucoma surgery comparison using propensity score matching

Corneal endothelial cell loss after Baerveldt glaucoma drainage device implantation in the anterior chamber

Donor sclera versus bovine pericardium as patch graft material in glaucoma implant surgery and the impact of a drainage suture

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