Treatment-Related Mortality From Infectious Complications in an Acute Leukemia Clinic

Torres-Flores, Jorge; Espinoza-Zamora, Ramiro; García-Méndez, Jorge; Cervera-Ceballos, Eduardo; Sosa-Espinoza, Alejandro; Zapata-Canto, Nidia

doi:10.14740/jh751

Cited by 14 publications

(12 citation statements)

References 45 publications

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“…The pathologic involvement of alveoli (ground glass shadow, GGO), interstitia (interlobular septal thickening, interlobular line, or central lobular shadow), and airways was exhibited by pulmonary imaging results in the youngsters (such as gas retention, bronchial wall thickening, bronchiectasis, or tree bud sign). The most widespread lesions were alveolar (n = 33 [65 %], peak RSI 5 [ [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] ]), followed by interstitial lesions (n = 6 [12 %], peak RSI 2 [ [1] , [2] , [3] ]) and airway lesions (n = 7 [14 %], peak RSI 2 [ [1] , [2] , [3] ]). The GGO was the most common finding (33/51, 65 %); patchy solid shadow (18/51, 35 %); and nodular shadow (15/51, 30 %) were also observed.…”

Section: Resultsmentioning

confidence: 99%

“…Treatment-related mortality (TRM) has recently been reported in child ALL-treatment clinical trials, ranging from 2 % to 5 % [ 5 ]. Infection is the most prevalent cause of TRM [ 6 ], and infection-related mortality (IRM) accounts for 64–73 % of all TRM cases [ [6] , [7] , [8] , [9] , [10] ], possibly due to the predominantly immunosuppressive effect of chemotherapy regimens. The evidence of infection sites revealed that 29–35 % of infections were respiratory, which is a higher ratio than the bloodstream [ 11 ], gastrointestinal, and central nervous system infections [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Retrospective computed tomography assessment of chemotherapy-related pneumonia with severity screening in pediatric acute lymphoblastic leukemia by radiological imaging

Gao,

Wei,

Chen

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Retrospective computed tomography assessment of chemotherapy-related pneumonia with severity screening in pediatric acute lymphoblastic leukemia by radiological imaging

Gao,

Wei,

Chen

et al. 2024

Heliyon

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“…Пациенты с онкогематологическими заболеваниями находятся в группе повышенного риска развития бактериальных, вирусных и грибковых инфекций. Частота развития фатальных бактериальных инфекционных осложнений у больных гемобластозами может достигать 27 % [20], что определяет необходимость проведения антибактериальной терапии, в том числе профилактической. Несмотря на это рациональное использование антибиотиков может служить эффективным методом борьбы с ПМК [21].…”

Section: клинические наблюдения // Clinical Casesunclassified

Atipical course of clostridial colitis in child with Hodgkin’s lymphoma

Lyanguzov

Ignatyev

Калинина

et al. 2022

Ross. ž. det. gematol. onkol.

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The wide antibiotics use in different areas of medicine has significantly increased the incidence of pseudomembranous colitis caused by Clostridium difficile. Strong necessity of antibacterial therapy in hematological patients is the reason of a higher frequency of this complication after programmed chemotherapy and hematopoietic stem cell transplantation. The atypical course of clostridial colitis makes it difficult to diagnose, leads to delay of treatment and fatal complications. We presented the case of clostridial colitis with atypical clinical manifestations in the 8-year-old child with Hodgkin’s lymphoma. Disease was complicated by colon perforation and fecal peritonitis, which required surgery and long-term rehabilitation. The analysis of publications devoted to clostridial colitis in patients with hematological malignancies was carried out and possible reasons of its atypical course was reviewed. The ways to improve the diagnosis, treatment and prevention of this serious complication are presented.

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“…Effective and timely treatment for children with ALL complicated by pneumonia arising from chemotherapy is crucial to ensure the best outcome from chemotherapy and increase the survival rate of children with leukemia. In addition, severe pneumonia was the leading cause of death for patients who failed chemotherapy (5). Previous studies mainly focused on hematogenous infection instead of pneumonia.…”

Section: Introductionmentioning

confidence: 99%

Clinical Features and Risk Factors of Severe Pneumonia in Children With Acute Lymphoblastic Leukemia

Liu

2022

Front. Pediatr.

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ObjectiveThis study aims to analyze the clinical characteristics of pediatric acute lymphoblastic leukemia (ALL) complicated by pneumonia and the risk factors of severe cases to preliminarily construct a prediction model for ALL complicated by severe pneumonia.MethodsA retrospective analysis was carried out on the clinical data of children diagnosed with ALL complicated by pneumonia hospitalized at the Department of Pediatrics of the Affiliated Hospital of Southwest Medical University between January 2013 and December 2020. The risk factors of severe ALL complicated by pneumonia were investigated with logistic regression analysis, and the risk prediction model was constructed.ResultsA total of 116 cases of pediatric ALL complicated by pneumonia were analyzed. There were 71 cases of mild pneumonia and 45 cases of severe pneumonia. The main clinical manifestations were cough in 112 cases and fever in 109. Pathogens were detected in 23 cases. Multiple regression factor analysis indicated that the use of hormones (OR 4.001, 95% CI: 1.505–10.632), neutropenia or agranulocytosis (OR 7.472, 95% CI: 2.710–20.602), hemoglobin (Hb) < 90 g/L (OR 3.270, 95% CI: 1.256~8.516), and C-reactive protein (CRP) >15 mg/L (OR 3.253, 95% CI: 1.209~8.751) were independent risk factors that were associated with severe pneumonia. Logistic regression was used to establish the risk prediction model of ALL with severe pneumonia. The p-value was 0.659. The area under the receiver operating characteristic curve was 0.851, and the sensitivity and specificity were 84.4 and 71.8%, respectively.ConclusionThe development of severe pneumonia may be affected by the use of hormones, neutropenia or agranulocytosis, Hb < 90 g/L, and CRP > 15 mg/L. The prediction model based on the risk factors is effective, which can provide a reference for the clinical evaluation of acute lymphoblastic leukemia with severe pneumonia.

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Treatment-Related Mortality From Infectious Complications in an Acute Leukemia Clinic

Cited by 14 publications

References 45 publications

Retrospective computed tomography assessment of chemotherapy-related pneumonia with severity screening in pediatric acute lymphoblastic leukemia by radiological imaging

Retrospective computed tomography assessment of chemotherapy-related pneumonia with severity screening in pediatric acute lymphoblastic leukemia by radiological imaging

Atipical course of clostridial colitis in child with Hodgkin’s lymphoma

Clinical Features and Risk Factors of Severe Pneumonia in Children With Acute Lymphoblastic Leukemia

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