Treatment-Related Radiation Toxicity Among Cervical Cancer Patients

Rubinsak, Lisa; Kang, Le; Fields, Emma C.; Carter, Jori S.; McGuire, William P.; Temkin, Sarah M.

doi:10.1097/igc.0000000000001309

Cited by 15 publications

(8 citation statements)

References 37 publications

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“…In cervix cancer, Rubinsak et al [35] reported that White women had increased toxicity and considered the effect multifactorial, potentially involving socioeconomic factors, access to care and willingness to seek care for toxicity symptoms. In their cohort, White women were more likely to smoke; smoking is linked with increased toxicity [33,34], probably mediated by vasculotoxic effects exacerbating radiation-induced damage [35]. However, other factors might play a role.…”

Section: Other Cancersmentioning

confidence: 99%

Effect of Race and Ethnicity on Risk of Radiotherapy Toxicity and Implications for Radiogenomics

et al. 2022

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Section: Other Cancersmentioning

confidence: 99%

Effect of Race and Ethnicity on Risk of Radiotherapy Toxicity and Implications for Radiogenomics

et al. 2022

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“…A sustentação teórica para a análise dos dados foi pautada em resultados de outros estudos relacionados à temática em questão, que abordam os significados e os desconfortos ocasionados pela braquiterapia (7,10,(12)(13)(14)(15)(16)(17)(18)(19) , e na Teoria do Conforto (20) .…”

Section: Métodounclassified

“…Os significados e os desconfortos abrangem as alterações físicas e emocionais decorrentes da doença e tratamento e seus efeitos colaterais (7,10,(12)(13)(14)(15)19) , as incertezas no futuro, as relações de afeto como estímulo ao enfrentamento da doença (7,10) , a religiosidade e a psicologia como suporte emocional (16,17) e o manejo da dor (18) .…”

Section: Métodounclassified

“…Quanto aos efeitos colaterais decorrentes da braquiterapia, relatados pelas participantes, eles replicam as evidências científicas. Estudo aponta que 21,2% das mulheres em braquiterapia pélvica apresentam toxicidades no trato gastrointestinal (17,3%) e geniturinárias (10%) (12,13) . Outro destaca a presença de sangramentos do tumor ou lesão relacionada (14) .…”

Section: Medo Do Tratamento E Desconfortos Relacionadosunclassified

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Mulheres com câncer ginecológico: significado da braquiterapia

Rosa

Duarte²,

Hames

et al. 2021

Cienc. Cuid. Saúde

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Objetivo: conhecer o significado da braquiterapia em mulheres com câncer ginecológico. Métodos: pesquisa qualitativa, descritiva e exploratória realizada com 32 mulheres, submetidas à braquiterapia em instituição oncológica de Santa Catarina, Brasil. Na coleta de dados, entre setembro de 2017 e julho de 2018, aplicou-se entrevista semiestruturada. As comunicações foram submetidas à análise de conteúdo, incluindo regras de enumeração para análise dos dados sociodemográficos, clínicos e para quantificação dos relatos agrupados. Publicações relacionadas com o tema e a Teoria do Conforto sustentaram teoricamente a inferência dos dados. Emergiram cinco categorias temáticas, neste artigo apresentam-se três. Resultados: a categoria “O medo e as crenças pessoais no enfrentamento do câncer ginecológico e da braquiterapia” destaca o medo da morte, o desejo pela cura e o apego à família e à religiosidade; “Medo do tratamento e desconfortos relacionados” retrata as alterações relacionadas aos contextos físico, psicológico e ambiental; “Dor como significado” revela a percepção dolorosa sentida pelas mulheres em decorrência da doença ou da braquiterapia. Conclusão: conhecer o significado da braquiterapia permite que os enfermeiros possam repensar a coleta de dados e o planejamento de enfermagem para melhor educação em saúde e redução dos desconfortos.

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“…The standard of care therapy for cervical cancer is based on combinations of radiation and chemotherapy. These modalities are highly toxic and cause significant morbidity ( 2 , 3 ). Although recent FDA approvals have added immune-based therapy to this armament, cervical cancer lags behind most other cancers in having molecular-based drugs available for therapeutic use.…”

Section: Introductionmentioning

confidence: 99%

Distinct mechanism of cervical cancer cell death caused by the investigational new drug SHetA2

Rai

Chandra²,

Kennedy³

et al. 2022

Front. Oncol.

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Drug-targetable vulnerabilities of cancer cells include their dependence on heat shock proteins (HSPs) to support elevated mitochondrial metabolism and counteract cell death factors. The investigational new drug SHetA2 targets these vulnerabilities in ovarian and endometrial cancer cells by disrupting complexes of the mortalin HSP with its client proteins (mitochondrial support proteins, metabolic enzymes, p53) leading to mitochondrial leakage of cytochrome c and apoptosis-inducing factor (AIF), and caspase-dependent apoptosis. Our objective was to evaluate the roles of mitochondrial damage and another SHetA2-target HSP protein, cytoplasmic heat shock cognate 70 (hsc70), in the mechanism of SHetA2 killing of cervical cancer cells. Cervical cancer cells responded to SHetA2 with excessive mitophagy that did not deter AIF leakage into the cytoplasm. Then, hsc70 was unable to prevent cytoplasmic AIF nuclear translocation and promotion of DNA damage and cell death, because SHetA2 disrupted hsc70/AIF complexes. The Cancer Genome Atlas analysis found that overexpression of hsc70, but not mortalin, was associated with worse cervical cancer patient survival. Use of specific inhibitors documented that AIF and mitophagy, but not caspases, contributed to the mechanism of SHetA2-induced cell death in cervical cancer cells. As validation, excessive mitophagy and lack of caspase activation were observed in SHetA2-inhibited xenograft tumors.

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Treatment-Related Radiation Toxicity Among Cervical Cancer Patients

Abstract: In patients with cervical cancer, radiation toxicity is correlated with lower body mass index, white race, and smoking. Despite technologic advances in radiotherapy planning and delivery, toxicity remains high and interventions to reduce the burden of treatment are needed.

Cited by 15 publications

References 37 publications

Effect of Race and Ethnicity on Risk of Radiotherapy Toxicity and Implications for Radiogenomics

Effect of Race and Ethnicity on Risk of Radiotherapy Toxicity and Implications for Radiogenomics

Mulheres com câncer ginecológico: significado da braquiterapia

Distinct mechanism of cervical cancer cell death caused by the investigational new drug SHetA2

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