2015
DOI: 10.1002/jso.24038
|View full text |Cite
|
Sign up to set email alerts
|

Treatment strategies for primary early‐stage sinonasal adenocarcinoma: A retrospective bi‐institutional case‐control study

Abstract: Our preliminary results suggest that endoscopic endonasal surgery could be used as a single treatment modality for primary early-stage low-grade sinonasal adenocarcinoma, resected with negative margins. Surgery followed by poRT offers the best treatment strategy not only for advanced-stage lesions but also for high-grade adenocarcinomas, regardless of the stage of disease at presentation.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
24
0
1

Year Published

2016
2016
2024
2024

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 33 publications
(25 citation statements)
references
References 24 publications
0
24
0
1
Order By: Relevance
“…Like Nicolai et al [9], we advocate a complete centripetal ethmoid sinus resection even for limited tumours. Recent studies advocate for a bilateral ethmoidectomy to prevent local recurrences controlaterally, in particular in the cases of ascertained occupational exposure [19,20]. Our attitude is strengthened by observations of preneoplastic and neoplastic foci in macroscopically uninvolved ethmoid areas in particular in patients exposed to carcinogenetic dusts [21].…”
Section: Discussionmentioning
confidence: 79%
See 1 more Smart Citation
“…Like Nicolai et al [9], we advocate a complete centripetal ethmoid sinus resection even for limited tumours. Recent studies advocate for a bilateral ethmoidectomy to prevent local recurrences controlaterally, in particular in the cases of ascertained occupational exposure [19,20]. Our attitude is strengthened by observations of preneoplastic and neoplastic foci in macroscopically uninvolved ethmoid areas in particular in patients exposed to carcinogenetic dusts [21].…”
Section: Discussionmentioning
confidence: 79%
“…Nicolai et al [9] limited the indications of RT to patients with advanced lesions or positive margins. In a recent multicentric retrospective study comparing patients with pT1 pT2 ITAC treated with or without postoperative RT, Turri-Zanoni et al showed that postoperative RT could be avoided in selected pT1 low-grade ITAC [19]. However, the previous studies showed that adjuvant RT improves local control regardless of surgical margins [27].…”
Section: Discussionmentioning
confidence: 97%
“…This is the largest study to date investigating SNAC, specifically evaluating demographics, grade, and treatment modalities as they relate to OS outcomes in patients with SNAC. Although high‐grade histology has been shown to be associated with worse OS, the literature is sparse regarding survival differences between low‐grade and high‐grade SNAC as moderated by demographics and treatment modalities. Our analysis suggested that the five‐year OS rate for SNAC is 54%; this is in agreement with what has been previously reported, which ranges from 54.5% to 66.8% …”
Section: Discussionmentioning
confidence: 99%
“…The current grading system of SNAC follows the general scheme of 1 (well differentiated), 2 (moderately differentiated), 3 (poorly differentiated), and 4 (undifferentiated), with grade 2 being the most common . Although low‐grade SNAC is known to have a more favorable OS than high‐grade SNAC based on small retrospective case series, no large database study has compared the survival benefit of different treatment modalities between low‐grade and high‐grade SNAC.…”
Section: Introductionmentioning
confidence: 99%
“…patients affected by low grade lesions treated with surgery alone or with adjuvant radiotherapy 32 In our report a single modality treatment, with surgery alone, was performed in case of radical surgical resection only for low stage and low grade diagnosis. None of them developed recurrence during follow-up and RT in these selected patients could be addressed as an overtreatment.…”
Section: Accepted Manuscriptmentioning
confidence: 92%