Treatment strategies in cancer from past to present

Yildizhan, Hatice; Barkan, Nezehat Pınar; Turan, Seçil Karahisar; Demiralp, Özerk; Demiralp, Fatma Duygu Özel; Uslu, Bengi; Özkan, Síbel A.

doi:10.1016/b978-0-12-813689-8.00001-x

Cited by 18 publications

(9 citation statements)

References 72 publications

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“…Cancer treatment options are usually decided by physicians considering the patient’s condition. For example, patients with specialized diseases cannot be assigned cancer as one disease . Indeed, the status of the patient and patient properties (age, gender, health status) are all important factors considered before planning the therapy.…”

Section: Introductionmentioning

confidence: 99%

The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

Nuzulia,

Mart,

Ahmed

et al. 2024

ACS Biomater. Sci. Eng.

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Embolization therapy involving biomaterials has improved the therapeutic strategy for most liver cancer treatments. Developing biomaterials as embolic agents has significantly improved patients' survival rates. Various embolic agents are present in liquid agents, foam, particulates, and particles. Some of the most applied embolic agents are microparticles, such as microspheres (3D micrometer-sized spherical particles). Microspheres with added functionalities are currently being developed for effective therapeutic embolization. Their excellent properties of high surface area and capacity for being loaded with radionuclides and alternate active or therapeutic agents provide an additional advantage to overcome limitations from traditional cancer treatments. Microspheres (nonradioactive and radioactive) have been widely used and explored for localized cancer treatment. Non-radioactive microspheres exhibit improved clinical performance as drug delivery vehicles in chemotherapy due to their controlled and sustained drug release to the target site. They offer better flow properties and are beneficial for the ease of delivery via injection procedures. In addition, radioactive microspheres have also been exploited for use as an embolic platform in internal radiotherapy as an alternative to cancer treatment. This short review summarizes the progressive development of non-radioactive and radioactive embolic microspheres, emphasizing material characteristics. The use of embolic microspheres for various modalities of therapeutic arterial embolization and their impact on therapeutic performance are also discussed.

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Section: Introductionmentioning

confidence: 99%

The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

Nuzulia,

Mart,

Ahmed

et al. 2024

ACS Biomater. Sci. Eng.

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“…Globally, cancer kills a staggering 9.3 million people annually [ 1 ]. Conventional methods to treat cancer, such as chemotherapy, are associated with severe and often debilitating systemic side effects [ 2 ]. Therefore, the encapsulation of anti-cancer drugs in nano-sized carrier systems has been proposed as an approach to increase the drug(s) concentration at a localized site while reducing their detrimental side effects.…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive Nanocarriers in Cancer Therapy

et al. 2022

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A number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they enable the safe delivery of the drugs while controlling their release at the tumor sites. Different intrinsic and extrinsic stimuli can be used to trigger drug release such as temperature, redox, ultrasound, magnetic field, and pH. The intracellular pH of solid tumors is maintained below the extracellular pH. Thus, pH-sensitive nanoparticles are highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review provides a survey of the different strategies used to develop pH-sensitive nanoparticles used in cancer therapy.

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“…In contrast to surgery and radiation, chemotherapy is used to treat cancer throughout the whole body, making it an invaluable tool for the treatment of disseminated or metastatic cancer. On the other hand, hormone therapy can only be used in the treatment of hormone-sensitive types of cancer and aims to stop hormone synthesis and prevent hormone-positive effects on cancer cells. − …”

Section: Introductionmentioning

confidence: 99%

Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment

AlSawaftah¹,

Pitt

Husseini³

2021

ACS Pharmacol. Transl. Sci.

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The delivery of chemotherapeutics to solid tumors using smart drug delivery systems (SDDSs) takes advantage of the unique physiology of tumors (i.e., disordered structure, leaky vasculature, abnormal extracellular matrix (ECM), and limited lymphatic drainage) to deliver anti-cancer drugs with reduced systemic side effects. Liposomes are the most promising of such SDDSs and have been well investigated for cancer therapy. To improve the specificity, bioavailability and anti-cancer efficacy of liposomes at the diseased sites, other strategies such as targeting ligands and stimulus-sensitive liposomes have been developed. This review highlights relevant surface functionalization techniques and stimuli-mediated drug release for enhanced delivery of anti-cancer agents at tumor sites, with a special focus on dual functionalization and design of multi-stimuli responsive liposomes.

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Treatment strategies in cancer from past to present

Cited by 18 publications

References 72 publications

The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

pH-Responsive Nanocarriers in Cancer Therapy

Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment

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