Treatment with Acarbose in Severe Hypoglycaemia Due to Late Dumping Syndrome

Wang, Congcong; Pang, Shuguang; Jiang, Qiang; Duan, Guanglan; Sun, Yongmei; Li, Mei

doi:10.7727/wimj.2012.266

Cited by 5 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Little effort has gone into finding effective options to decrease severity and frequency of DS events; moreover, the frequency of severe DS and number of DS-related deaths are likely under reported. Acarbose has been shown to be an inexpensive option that substantially improves overall quality of life of post-bariatric subjects affected by DS, particularly the late dumping 14–16…”

Section: Discussionmentioning

confidence: 99%

“…was additionally prescribed. The dose of 50 mg before meals has been extensively studied and standardized,14–16 whereas the addition of simethicone was thought to attenuate the most important adverse effects of acarbose use (abdominal cramps, bloating, and flatulence).…”

Section: Methodsmentioning

confidence: 99%

“…Acarbose, a glucosidase inhibitor that slows carbohydrate digestion and is primarily prescribed as an antidiabetic agent has been shown to be effective in late DS,6,14–16 but has not been studied for early DS; rationale of protection of late dumping by acarbose is based on the fact that this drug delays glucose absorption; thus, hyperinsulinemic hypoglycemia due to excessive insulin release by incretin and by direct glucose stimulation is prevented by acarbose 14,16. Furthermore, acarbose has the potential benefit to prevent beta-cell hypertrophy and hyperplasia; indeed, hyperinsulinemic hypoglycemia, one of the main cornerstone aspects of DS, has a significant improvement by acarbose 6,17,18…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients

Cadegiani¹,

Silva²

2016

DMSO

View full text Add to dashboard Cite

ObjectiveAcarbose is a glucosidase inhibitor that slows carbohydrate digestion. It could thus be effective to promote remission of dumping syndrome (DS). Previous studies associating acarbose and late dumping, although not early dumping, have been reported. Herein, we aimed to evaluate the role of acarbose in dumping syndrome prevention and treatment and in resistive exercises resistance in bariatric subjects.MethodsBariatric patients with DS and complete adherence to diet plan and resistive exercises were included (n=25). Number of early and late episodes, self-referred intensity of each episode, and ability to increase intensity of resistive exercise were evaluated, on a 0–10 scale. Acarbose was administered orally (50 mg) for 6 months, 4–5 times a day before meals.ResultsAcarbose administration was associated with a decrease in the number of early (2.18–0.31) and late (2.79–0.12) episodes per week and intensity of each episode (6.10–1.65) and an increase in the ability to perform resistive exercises (3.03–7.12). Complete remission of DS was seen in 21 patients (84%), which persisted for 6 months with the use of acarbose.ConclusionAcarbose prevented dumping in almost all studied subjects and helped improve exercise capacity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients

Cadegiani¹,

Silva²

2016

DMSO

View full text Add to dashboard Cite

show abstract

“…α-Glukosidase-Inhibitoren reduzieren die Glukoseresorption in Duodenum und Jejunum und hemmen dadurch die GLP-1-und Insulinsekretion [1,19,20]. Es ist mit gastrointestinalen Nebenwirkungen (Diarrhoen, Flatulenzen, abdominelle Schmerzen) zu rechnen, die oftmals zum Abbruch der Therapie führen.…”

Section: Introductionunclassified

Unklare Lymphadenopathie mit Panzytopenie bei einer Patientin mit rezidivierenden Hypoglykämien

Lindmeyer

Nauck

2021

Diabetologie und Stoffwechsel

View full text Add to dashboard Cite

ZusammenfassungEine Patientin wurde aufgrund rezidivierender postprandialer Hypoglykämien nach Roux-en-Y-Magenbypass mit Diazoxid behandelt, nachdem eine Ernährungsumstellung keine Symptomlinderung erzielt hatte. Nach Eindosierung von Diazoxid mit guter Akutverträglichkeit wurde die Patientin entlassen. Eine Woche nach Therapieeinleitung kam es zu einer Lymphadenopathie und Panzytopenie. Es fanden sich keine Hinweise auf das Vorliegen eines Infekts. Nach Absetzen von Diazoxid sistierten die Beschwerden. Unser Fallbericht weist auf seltene unerwünschte hämatologische Arzneimittelwirkungen unter Diazoxid hin.

show abstract

“…Current treatment for dumping syndrome includes pharmacological and surgical interventions. Dietary supplements (pectin, guar gum, acarbose 25-30 ), somatostatin analogs (pasireotide, 5,31-33 octreotide 31 ), miglitol, 34-36 iraglutide, 37 exendin-(9-39), 38 and diazoxide 39 are prescribed for postprandial hypoglycemia or hyperglycemia caused by dumping syndrome. The GLP-1 receptor blocker can improve hypoglycemia caused by dumping syndrome.…”

Section: Introductionmentioning

confidence: 99%

Herbal Medicine for Dumping Syndrome: A Systematic Review and Meta-Analysis

Hong

Park²,

Noh

et al. 2019

Integr Cancer Ther

View full text Add to dashboard Cite

Background: Dumping syndrome is a common complication of surgical treatment of gastric cancer, but conventional therapy has limitations related to symptom care due to its structural cause and the decreased quality of life. Objectives: The objective of this review was to assess the clinical evidence for the effectiveness of herbal medicine as a treatment for dumping syndrome. Methods: A literature review was conducted using 16 databases from their inceptions to March 2018. All randomized controlled trials (RCTs) of herbal medicine used to treat dumping syndrome patients were included and meta-analyzed. Methodological quality was assessed using the Cochrane Handbook for Systematic Reviews of Interventions. Results: A total of 174 dumping syndrome patients of 3 trials met all inclusion criteria. Two trials assessed the effectiveness of herbal medicine on the symptom response rate compared with conventional pharmacotherapy. Their results suggested significant effects in favor of herbal medicine (risk ratio [RR] = 1.37, 95% confidence interval [CI] = 1.16-1.63, P = .0003, heterogeneity τ2 = 0, χ2 = 0.02, P = .88, I2 = 0%). One trial assessed its effectiveness on the improvement rate of overall symptoms compared with conventional conservative complex therapy, such as postural management, diet regulation, and counseling (RR = 1.23, 95% CI = 0.96-1.58). Conclusions: Due to the small sample size, scarcity of reported articles, and lack of quality of the current RCTs, it was concluded that the effectiveness of herbal medicine in treating dumping syndrome is unclear.

show abstract

Treatment with Acarbose in Severe Hypoglycaemia Due to Late Dumping Syndrome

Cited by 5 publications

References 5 publications

Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients

Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients

Unklare Lymphadenopathie mit Panzytopenie bei einer Patientin mit rezidivierenden Hypoglykämien

Herbal Medicine for Dumping Syndrome: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About