Treatment with piroxicam before embryo transfer increases the pregnancy rate after in vitro fertilization and embryo transfer

Administration of the nonsteroidal anti-inflammatory drug tolfenamic acid at embryo transfer improves maintenance of pregnancy and embryo survival in recipient mice

“…Similar results were found in women undergoing IVF and receiving 75 mg of aspirin daily from the day of embryo transfer until pregnancy test in which higher pregnancy rates were reported [28]. Moreover, treatment of women with piroxicam, an oxicam kind of NSAID, administrated 1-2 h before embryo transfer increased implantation and pregnancy rates, in both fresh and frozen-thawed embryo transfer cycles [29]. The mechanisms involved in these effects are still not clear.…”

Oxytocin antagonists may improve infertility treatment

“…Progesterone supplementation, even when acting on uterine receptivity, improving endometrial status, and decreasing uterine contractions, shows no benefit for pregnancy rates after IVF-ET (7). Studies assessing the effectiveness of piroxicam (cyclooxygenase inhibitor) and ritodrine (b 2 -adrenoreceptor agonist) have shown a positive effect on pregnancy rates (8,9), but these drugs have failed to enter routine clinical use because of safety concerns.Oxytocin antagonists constitute a new class of drugs introduced for the tocolytic treatment of preterm labor. Atosiban (TRACTOCILE; Ferring Pharmaceuticals A/S, Copenhagen, Denmark), a mixed vasopressin V 1A /oxytocin antagonist registered in Europe for the treatment of imminent premature birth, is more uterine selective and has minimal side effects compared with b 2 -adrenoreceptor agonists (10).…”

“…Progesterone supplementation, even when acting on uterine receptivity, improving endometrial status, and decreasing uterine contractions, shows no benefit for pregnancy rates after IVF-ET (7). Studies assessing the effectiveness of piroxicam (cyclooxygenase inhibitor) and ritodrine (b 2 -adrenoreceptor agonist) have shown a positive effect on pregnancy rates (8,9), but these drugs have failed to enter routine clinical use because of safety concerns.…”

Myoinositol Causes Myometrial Contractions in Isolated Non-Pregnant Rat Myometrium

“…After the observation of increased frequency of uterine contraction during ovarian stimulation cycles compared with the corresponding phase of natural menstruel cycles in a number of studies, a new pharmaterapeutic target arised and investigation of drugs reducing the contractility of uterus increased and conflicting results are found (25,26). Moon and colleagues reported that piroxicam, a nonsteroidal anti-inflammatory drug (NSAID), increased the implantation and pregnancy rate in women undergoing assistedreproductive technology (ART) (27). In contrast, indomethacin which is a different type of NSAID did not improve the implantation rates (28).…”