TREE NUTS ALLERGY: Knowledge, gaps and practical implications

Echeverría-Zudaire, L.

doi:10.1016/j.aller.2020.05.001

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…The epithelial barrier dysfunction characteristic of atopic dermatitis is a confirmed risk factor for the development of allergic sensitization, food allergy and other allergic diseases. Many recent studies have demonstrated the connection between skin and digestive tract [23,24]. Damaged keratinocytes produce IL-33, that stimulates group 2 innate lymphoid cells (ILC2) in the small intestine.…”

Section: Discussionmentioning

confidence: 99%

Tree Nut and Peanut Allergy in a Portuguese Pediatric Cohort- Clinical Characterization and Anaphylaxis PredictorsLeonor Esteves

Caldeira

2023

PAPN

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Background: Tree nuts and peanuts (TN/P) are frequent causes of anaphylaxis in children. Our aim was to characterize a Portuguese pediatric cohort with TN/P allergy and to assess skin tests (ST), specific IgE (sIgE) and molecular components (mcIgE), as well as sIgE/total IgE ratio's utility in anaphylaxis prediction. Methods:Retrospective study (2017-2021) of pediatric patients with TN/P allergy, grouped according to reaction severity (group 1-anaphylaxis vs group 2-milder reaction). ST mean papule diameter (MPD), sIgE (ImmunoCAP®), mcIgE (ISAC®) and sIgE/total IgE ratio were compared (SPSS®, p<0.05: statistically significant).Results: A total of 98 patients were included, 64% male. 88% had concomitant allergic disease and 40% had allergy family history. The more common culprit nuts were peanut (47%), walnut (31%) and hazelnut (13%). Index reaction symptoms were mostly cutaneous (46%), followed by anaphylaxis (36%). Chestnut and cashew sensitization were significantly associated with anaphylaxis (OR=5.023, p=0.002; OR=2.901, p=0.018). MPD was higher in G1 for almond, cashew, and pistachio (p<0.05). sIgE was not a good severity predictor for any TN/P, however, a significantly higher sIgE/total IgE ratio was found in G1 for walnut (p=0.023). McIgE was obtained in 49%: peanut Ara h2 and Ara h6 were more represented in G1 (2.8 vs 0 ISU-E, p=0.042; 1.3 vs 0 ISU-E, p=0.020). Conclusion:Peanut, hazelnut and walnut were the most frequent nuts involved in TN/P allergy. Anaphylaxis was the first manifestation in 36% of the patients, significantly more frequent in chestnut and cashew allergic children. The authors suggest that MPD should be valued not only for diagnosis, but also for anaphylaxis risk prediction in almond, cashew, and pistachio allergic patients. sIgE/total IgE ratio seems to be useful in anaphylaxis prediction.

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Section: Discussionmentioning

confidence: 99%

Tree Nut and Peanut Allergy in a Portuguese Pediatric Cohort- Clinical Characterization and Anaphylaxis PredictorsLeonor Esteves

Caldeira

2023

PAPN

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“…These in turn produce IL-4 and IL-13, which leads to the expansion of activated mast cells, resulting in an increment of intestinal permeability and consequent transmission of allergens that can trigger food allergy. 19,20 Nut reactions may be severe on the first contact. About one third of our patients presented with anaphylaxis, and more than half were polysensitized to several nuts, which in accordance with recent data of international cohorts.…”

Section: Discussionmentioning

confidence: 99%

Tree nut and peanut allergy in a Portuguese pediatric cohort -- clinical characterization and anaphylaxis predictors

Brás

Caldeira

Varandas

et al. 2023

Preprint

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Background: Tree nuts and peanuts (TN/P) are frequent causes of anaphylaxis in children. Aim: to characterize a Portuguese pediatric cohort with TN/P allergy and to assess skin tests (ST), specific IgE (sIgE) and molecular components (mcIgE), as well as sIgE/total IgE ratio’s utility in anaphylaxis prediction. Methods: Retrospective study (2017-2021) of pediatric patients with TN/P allergy, grouped according to reaction severity (anaphylaxis–G1 vs milder reaction–G2). ST mean papule diameter (MPD), sIgE (ImmunoCAP®), mcIgE (ISAC®) and sIgE/total IgE ratio were compared (SPSS®, p<0.05: statistically significant). Results: 98 patients, 64% male, 88% concomitant allergic disorder, 40% allergy family history. Major culprit nuts: peanut (63%), hazelnut (59%) and walnut (53%). Index reaction manifestations were mostly cutaneous (46%), followed by anaphylaxis (36%). Chestnut and cashew sensitizations were significantly associated with anaphylaxis (OR=5.023, p=0.002; OR=2.901, p=0.018). MPD was higher in G1 for almond, cashew and pistachio (p<0.05). sIgE was not a good severity predictor for any TN/P, however, a significantly higher value of sIgE/total IgE ratio was found in G1 for walnut (p=0.023). mcIgE was obtained in 49%: peanut Ara h2 and Ara h6 were more represented in G1 (2.8 vs 0 ISU-E, p=0.042; 1.3 vs 0 ISU-E, p=0.020). Conclusion: Peanut, hazelnut and walnut were the most frequent nuts. Anaphylaxis was the first manifestation in 36%, significantly higher in chestnut and cashew allergic children. MPD should be valued not only for diagnosis, but also for anaphylaxis risk prediction in almond, cashew and pistachio allergic patients. sIgE/total IgE ratio seems to be useful in anaphylaxis prediction.

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Identification and Annotation of Peptide Allergens in Prunus dulcis

Singh

Upadhyay²

2022

Int J Pept Res Ther

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Approximately, 10% of the world population is facing the challenge of food allergy in direct or indirect way. In this study, a genome-wide identi cation and annotation of the novel putative allergen from Almond is performed. Initially, the whole proteome of Almond (31,000 proteins) was scanned by Allergenonline, a publically available database of already reported allergens from different sources. The detailed analysis suggests that there are 430 putative allergens which reduced to 45 on motif-based screening using AllFam database. These predicted allergens are annotated for their function by using PFAM, GO databases and orthology analysis. To validate our prediction, we have used structural insights of allergen and antibody interactions for one of the predicted putative allergen protein, homologous to Pru ar 3.0101allergen from Apricot. The structure of putative allergen was modeled and molecular docking studies were performed against the antibody. The best docked conformation was subjected to molecular simulation studies to con rm the stable binding of these two molecules. This detailed analysis suggests that the identi ed allergen will show cross reactivity similar to Pru ar 3.0101 allergen from Apricot. This is one of the rst report of identifying and annotating the homologous of Pru ar 3.0101 allergen in Almond.

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TREE NUTS ALLERGY: Knowledge, gaps and practical implications

Cited by 3 publications

References 22 publications

Tree Nut and Peanut Allergy in a Portuguese Pediatric Cohort- Clinical Characterization and Anaphylaxis PredictorsLeonor Esteves

Tree Nut and Peanut Allergy in a Portuguese Pediatric Cohort- Clinical Characterization and Anaphylaxis PredictorsLeonor Esteves

Tree nut and peanut allergy in a Portuguese pediatric cohort -- clinical characterization and anaphylaxis predictors

Identification and Annotation of Peptide Allergens in Prunus dulcis

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