Trefoil factor family domain peptides in the human respiratory tract

Silva, Elisabeth dos Santos; Ulrich, Martina; Döring, Gerd; Botzenhart, K; Gött, Peter

doi:10.1002/(sici)1096-9896(200002)190:2<133::aid-path518>3.0.co;2-b

Cited by 68 publications

(40 citation statements)

References 29 publications

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“…was undetectable (19,20,27). The current study analyzed the expression of TFF1 in human nasal mucosa using RT-qPCR and identified a significant decrease in the expression of TFF1 in the nasal mucosa of patients with CRS and NP.…”

Section: Discussionmentioning

confidence: 81%

“…TFF1, also known as pS2, contains 60 amino acid residues and is mainly expressed in the gastric mucosa as a protective factor against gastric damage (18). However, it has also been demonstrated that TFF1 is widely expressed in human and mouse nasal mucosa, suggesting that it may also regulate the inflammatory response in the respiratory tract (19)(20)(21). The expression and function of TFF1 in CRS and NP remains unclear.…”

Section: Introductionmentioning

confidence: 77%

“…TFF1 is an important regulator of epithelial cell migration and the inflammatory process in the airway, which may serve an important regulatory role in the process of airway defense and injury repair (15,20). TFF1 delays the transition from G1 to the S-phase in the cell cycle, thus regulating tumor inhibition, mucosal protection, cell apoptosis and differentiation (30).…”

Section: Discussionmentioning

confidence: 99%

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Expression of Clara cell 10-kDa protein and trefoil factor family 1 in patients with chronic rhinosinusitis and nasal polyps

Wang

2018

Exp Ther Med

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Abstract. The current study measured the expression of Clara cell 10-kDa protein (CC10) and trefoil factor family 1 (TFF1) in the sinus mucosa of patients exhibiting chronic rhinosinusitis (CRS) and nasal polyps (NP). CC10 and TFF1 expression in the sinus mucosa of the control group and patients with CRS and NP was determined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), western blotting and immunohistochemistry. The correlation between CC10 and TFF1 expression was further analyzed using Spearman's correlation analysis. The expression of TFF1 was significantly increased in the sinus mucosa of patients with CRS and NP, whereas CC10 expression was significantly decreased compared with controls. Spearman's correlation analysis identified a negative correlation between CC10 and TFF1 expression in the sinus mucosa of patients with CRS and NP. The results of immunohistochemistry and RT-qPCR were consistent with each other. Hematoxylin and eosin staining revealed notable lesions in the mucous membranes, goblet cells and cilia of sinus mucosa samples from patients with CRS and NP. The negative correlation between CC10 and TFF1 expression during the progression of CRS and NP suggest that CC10 and TFF1 may serve important roles in its pathogenesis.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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Expression of Clara cell 10-kDa protein and trefoil factor family 1 in patients with chronic rhinosinusitis and nasal polyps

Wang

2018

Exp Ther Med

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“…S3C and S3D). As all four transgenic founder lines yielded similar reporter staining patterns, we concluded that the Tff1-CreERT2 transgene replicates the expression of endogenous Tff1 (25,26), and confers recombinase activity to long-lived stem/progenitor cells, particularly within the antrum.…”

Section: Generation Of Tg(tff1-creert2) Micementioning

confidence: 99%

Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model

et al. 2016

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About 5% to 10% of human gastric tumors harbor oncogenic mutations in the KRAS pathway, but their presence alone is often insufficient for inducing gastric tumorigenesis, suggesting a requirement for additional mutagenic events or microenvironmental stimuli, including inflammation. Assessing the contribution of such events in preclinical mouse models requires Cre recombinase-mediated conditional gene expression in stem or progenitor cells of normal and transformed gastric epithelium. We therefore constructed a bacterial artificial chromosome containing transgene (Tg), comprising the regulatory elements of the trefoil factor 1 (Tff1) gene and the tamoxifen-inducible Cre recombinase (CreERT2)-coding sequence. The resulting Tg (Tff1-CreERT2) mice were crossed with mice harboring conditional oncogenic mutations in Kras or Braf. The administration of tamoxifen to the resulting adult Tg(Tff1-CreERT2);Kras LSL-G12D/þ and Tg(Tff1-CreERT2);Braf LSL-V600E/þ mice resulted in gastric metaplasia, inflammation, and adenoma development, characterized by excessive STAT3 activity. To assess the contribution of STAT3 to the spontaneously developing gastric adenomas in gp130

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“…In addition, TFF3 has also been shown to function as an epithelial anti-apoptotic factor, and neural signaling peptide [4,14,15]. TFF3 expression has also been documented in other tissues including the uterus [16], breast [17], hypothalamus/pituitary [15,18], salivary glands [19,20], conjunctiva [21,22], and respiratory tract [22,23].…”

Section: Introductionmentioning

confidence: 99%

Trefoil factor 3 overexpression in prostatic carcinoma: Prognostic importance using tissue microarrays

et al. 2004

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Trefoil factor family domain peptides in the human respiratory tract

Cited by 68 publications

References 29 publications

Expression of Clara cell 10-kDa protein and trefoil factor family 1 in patients with chronic rhinosinusitis and nasal polyps

Expression of Clara cell 10-kDa protein and trefoil factor family 1 in patients with chronic rhinosinusitis and nasal polyps

Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model

Trefoil factor 3 overexpression in prostatic carcinoma: Prognostic importance using tissue microarrays

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