Treinamento aeróbico prévio à compressão nervosa: análise da morfometria muscular de ratos

Artifon, Elisangela Lourdes; Silva, Lígia Inez; Ribeiro, Lucinéia de Fátima Chasko; Brancalhão, Rose Meire Costa; Bertolini, Gladson Ricardo Flor

doi:10.1590/s1517-86922013000100014

Cited by 5 publications

(9 citation statements)

References 25 publications

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“…Euthanize proposed in our study occurred in 3rd day and 15th day after the surgery because 3 days after peripheral nervous injury, no muscle hypotrophy characteristics were observed; ( 5 ) and within 2 weeks of injury, Wallerian degeneration is well documented, ( 15 ) i.e., the occurrence of change with visits to reduce hypotrophy can be computed by the cryotherapy.…”

Section: Discussionmentioning

confidence: 75%

“…About 30 days after the procedure, the muscle and nerve recovery spontaneously and it does not allow observation of these effects. ( 5 – 8 ) However, when muscular hypotrophy is seen, such tissue can be replaced by conjunctive, therefore, mainly formed with collagenous, which result in loss of function, when nerve regeneration does not occur appropriately. ( 9 )…”

Section: Introductionmentioning

confidence: 99%

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Analysis of the muscle tissue of Wistar rats submitted to the sciatic nerve compression model and cryotherapy

Karvat

Kakihata

Vieira

et al. 2018

Einstein (São Paulo)

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Objective:To evaluate the effects of right sciatic nerve compression and cryotherapy on muscle tissue.Methods:We used 42 male Wistar rats, subdivided in the following Groups Control, Injury 3, Injury 8 and Injury 15 submitted to nerve compression and euthanized in the 3rd, 8th and 15th day after surgery. The Cryotherapy Injury 3 was entailed treatment with cryotherapy by immersion of the animal in recipient for 20 minutes during 1 day, then animals were euthanized at the 3rd day after surgery, and the Cryotherapy Injury 8 and the Cryotherapy Injury 15 was treated for 6 days, and euthanized at the 8th and 15th day after surgery. Functional evaluation was performed by the grasping strength of the right pelvic limb. The right tibialis anterior muscles were evaluated for mass, smaller diameter and cross-sectional area. In the Cryotherapy Injury 8 and the Cryotherapy Injury 15 groups, the hydroxyproline was dosed in the right soles.Results:In the compression there was a significant difference in the Injury Groups compared with the Control Group (p<0.05). In the smaller diameter, the compression in Control Group was higher than Injury 8 (p=0.0094), Injury 15 (p=0.002) and Cryotherapy Injury 15 (p<0.001) groups. The comparison between groups with euthanasia in the same post-operative period, a significant difference (p=0.0363) was seen in day 8th after surgery, and this result in Cryotherapy Injury Group was greater than Injury Group. In the fiber area, Control Group was also higher than the Injury 8 (p=0.0018), the Injury 15 (p<0.001) and the Cryotherapy Injury 15 (p<0.001). In hydroxyproline, no significant difference was seen between groups.Conclusion:Nerve damage resulted in decreased muscle strength and trophism, the cryotherapy delayed hypotrophy, but this effect did not persist after cessation of treatment.

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Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Analysis of the muscle tissue of Wistar rats submitted to the sciatic nerve compression model and cryotherapy

Karvat

Kakihata

Vieira

et al. 2018

Einstein (São Paulo)

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“…All but one study ( 42 ) used adult, male rodents; with Wistar rats being the most common species used (6/11 studies) ( 37 , 39 , 44 – 47 ), followed by Sprague-Dawley rats (3/11 studies) ( 40 , 42 , 43 ) and mice (2/11 studies) ( 38 , 41 ) All neuropathic pain models were performed by injuring the sciatic nerve, seven included studies used a chronic constriction injury (CCI) model ( 37 , 39 – 43 , 46 ), while four studies used a nerve crush model ( 38 , 44 , 45 , 47 ). The exercise programs administered before the lesion mostly consisted of aerobic exercise (9/11 studies), such as running ( 38 , 40 – 43 , 46 ) or swimming ( 37 , 39 , 47 ), but also included aquatic resistance training programs ( 44 , 45 ). The primary outcome, neuroimmune responses, such as cytokines, neurotrophic factors, microglia, and antioxidants, were measured in six studies ( 38 , 40 – 43 , 46 ).…”

Section: Resultsmentioning

confidence: 99%

“…There were two muscle morphometric measures that were assessed by two studies (48 rodents). Muscle fibre cross-sectional area of the soleus ( 37 , 45 ) and plantaris ( 40 ) muscle following peripheral neuropathy induction was significantly larger with pre-injury exercise (pooled data, 3 studies, 4 comparisons, n=48 rodents, SMD: 0.91, 95%CI: 0.27 to 1.54) compared to non-exercise control ( Figure 7.1 ). Pre-injury exercise was not different than the non-exercise control in muscle fibre diameter (pooled data, 2 studies, n=28, SMD: 0.76, 95%CI: -0.07 to 1.60) ( Figure 7.2 ) ( 37 , 45 ).…”

Section: Resultsmentioning

confidence: 99%

“…The original search identified 17,431 records. After title and abstract screening, 128 full texts were assessed for eligibility, of which 11 articles originating from 10 experiments were included in the review (37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47). Reference lists of included studies and of relevant reviews (9,48) did not reveal additional studies.…”

Section: Study Selectionmentioning

confidence: 99%

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The potential protective effects of pre-injury exercise on neuroimmune responses following experimentally-induced traumatic neuropathy: a systematic review with meta-analysis

Koop,

Sleijser-Koehorst,

Hooijmans

et al. 2023

Front. Immunol.

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Pre-clinical evidence shows that neuropathy is associated with complex neuroimmune responses, which in turn are associated with increased intensity and persistence of neuropathic pain. Routine exercise has the potential to mitigate complications of future nerve damage and persistence of pain through neuroimmune regulation. This systematic review aimed to explore the effect of pre-injury exercise on neuroimmune responses, and other physiological and behavioural reactions following peripheral neuropathy in animals. Three electronic databases were searched from inception to July 2022. All controlled animal studies assessing the influence of an active exercise program prior to experimentally-induced traumatic peripheral neuropathy compared to a non-exercise control group on neuroimmune, physiological and behavioural outcomes were selected. The search identified 17,431 records. After screening, 11 articles were included. Meta-analyses showed that pre-injury exercise significantly reduced levels of IL-1β (SMD: -1.06, 95% CI: -1.99 to -0.13, n=40), but not iNOS (SMD: -0.71 95% CI: -1.66 to 0.25, n=82). From 72 comparisons of different neuroimmune outcomes at different anatomical locations, vote counting revealed reductions in 23 pro-inflammatory and increases in 6 anti-inflammatory neuroimmune outcomes. For physiological outcomes, meta-analyses revealed that pre-injury exercise improved one out of six nerve morphometric related outcomes (G-ratio; SMD: 1.95, 95%CI: 0.77 to 3.12, n=20) and one out of two muscle morphometric outcomes (muscle fibre cross-sectional area; SMD: 0.91, 95%CI: 0.27 to 1.54, n=48). For behavioural outcomes, mechanical allodynia was significantly less in the pre-injury exercise group (SMD -1.24, 95%CI: -1.87 to -0.61) whereas no overall effect was seen for sciatic function index. Post hoc subgroup analysis suggests that timing of outcome measurement may influence the effect of pre-injury exercise on mechanical allodynia. Risk of bias was unclear in most studies, as the design and conduct of the included experiments were poorly reported. Preventative exercise may have potential neuroprotective and immunoregulatory effects limiting the sequalae of nerve injury, but more research in this field is urgently needed.

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Therapeutic ultrasound after sciatic nerve compression of Wistar rats

Bertolini

Karvat

Kakihata

et al. 2017

Neurological Research

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Treinamento aeróbico prévio à compressão nervosa: análise da morfometria muscular de ratos

Cited by 5 publications

References 25 publications

Analysis of the muscle tissue of Wistar rats submitted to the sciatic nerve compression model and cryotherapy

Analysis of the muscle tissue of Wistar rats submitted to the sciatic nerve compression model and cryotherapy

The potential protective effects of pre-injury exercise on neuroimmune responses following experimentally-induced traumatic neuropathy: a systematic review with meta-analysis

Therapeutic ultrasound after sciatic nerve compression of Wistar rats

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