Trekrezan as a stimulator of muscle strength and endurance. Possible molecular mechanisms of action

Contribution of the Scientific School of Academician M.G. Voronkov to the Development of the Chemistry of Biologically Active Atranes (Protatranes and Hydrometallatranes) (A Review)

“…Administration of chlorocrezacin significantly enhances the expression of matrix RNA of tryptophanyl-tRNA-synthase (by 60% in the 15 mg/kg dose). It should be noted that trecresan increases the activity of TRSase by only 20% in comparison with the control in the dose almost twice higher (25 mg/kg) than that of chlorocrezacin [56]. Chlorocrezacin is more efficient than trecresan in the inhibition of thrombocytes aggregation, it improves the antithrombotic properties of the vascular cells, decelerates peroxide oxidation of lipids, and enhances the tolerance of the blood cells to the action of disintegrating agents [57].…”

“…Its protective activity and efficiency exceed these of a known antitumor drug 5-fluorouracil [54]. Chlorocrezacin can enhance the resistance of the vascular system to cholesterol during atherosclerotic process [55].…”

“…-inhibition of acid phospholipase Al and suppression of general activity of alkaline phospholipase A2 of mononuclear leucocytes by zincatrane [114,115] -promotion of the expression of matrix RNA of tryptophanyl-tRNA-synthase (exhibiting prominent antiangiogenic and antiatherogenic action) by zincatrane [112][113][114][115][116];…”

“…-zincatrane-stimulated expression of the gene of coactivator PGC-1α, the use of which increases the content of mitochondria in the muscle tissue and enhancement in the ability to work of the cross-striped muscular system [119].…”