TREM-1; is It a Pivotal Target for Cardiovascular Diseases?

Abstract

Cardiovascular Diseases (CVDs) are still menacing and killing adults worldwide, notwithstanding the tremendous effort, to decrease their related mortality and morbidity. Lately, a growing body of evidences indicated that inflammation plays a pivotal role in the pathogenesis and complications of CVDs. A receptor of the immunoglobulin superfamily, triggering receptor expressed on myeloid cells -1 (TREM-1) was shown to induce and to amplify the inflammation in both acute and chronic diseases pathogenesis and progression and hence it is one of the important factors that complicates CVDs. Thus, studies endeavored to investigate the role played by TREM-1 in CVDs with respect to their etiologies, complications and possible therapeutics. We examined here, for the first time, the most relevant studies regarding TREM-1 involvement in CVDs. We summarized the finding after critically analyzing them and made some suggestions for furtherance of the investigations with the aim to utilize TREM-1 and its pathways for diagnostic, management and prognosis of CVDs. Overall, TREM-1 was found to be involved in the pathogenesis of acute and chronic cardiovascular conditions like Acute myocardial infraction (AMI) and atherosclerosis as well. Although most therapeutic approaches are yet to be elucidated, present research outcome displays a promising future to utilize TREM-1 pathway as potential target to understand and manage CVDs.

The Role of Chemokines in Psoriasis—An Overview

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The Role of Histone Acetylation and the Microbiome in Phytochemical Efficacy for Cardiovascular Diseases

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Pathogenesis and prevention of risk of cardiovascular events in patients with pneumococcal community‐acquired pneumonia

“…In this context, there has also been a revival of interest in the clinical utility of measurement of circulating soluble triggering receptor expressed on myeloid cells (sTREM‐1), described in an earlier study as being a useful pro‐inflammatory biomarker in the diagnosis and prognosis, including mortality, in patients with severe all‐cause CAP . A more recent study has identified sTREM‐1 as being a contributor to the pathogenesis of acute and chronic CV conditions, including AMI, with the authors contending that measurement of this biomarker has significant implications for diagnosis, management and prognosis of CV disorders .…”