The southwest of Songnen Plain, Northeast China, has an arid climate and is a typical concentrated distribution area of saline-alkali soil. The terrain here is low-lying, with many small, shallow lakes that are vulnerable to climate change. This paper used Landsat satellite remote sensing images of this area from 1985 to 2015 to perform interpretation of lake water bodies, to classify the lakes according to their areas, and to analyze the spatial dynamic characteristics of lakes in different areas. During the 30 years from 1985 to 2015, the number of lakes in the study area decreased by 71, and the total lake area decreased by 266.85 km2. The decrease was more serious in the east and northeast, and the appearance and disappearance of lakes was drastic. The Mann–Kendall test method was used to analyze trends in meteorological factors (annual mean temperature, annual precipitation, and annual evaporation) in the study area and perform mutation tests. Through correlation analysis and multiple generalized linear model analysis, the response relationship between lake change and climate change was quantified. The results showed that the average temperature in the area is rising, and the annual precipitation and evaporation are declining. Temperature and precipitation mainly affected lakes of less than 1 km2, with a contribution rate of 31.2% and 39.4%, and evaporation had a certain correlation to the total lake area in the study area, with a contribution rate of 60.2%. Small lakes are susceptible to climatic factors, while large lakes, which are mostly used as water sources, may be influenced more by human factors. This is the problem and challenge to be uncovered in this article. This research will help to improve our understanding of lake evolution and climate change response in saline-alkali areas and provide scientific basis for research into lakes’ (reservoirs’) sustainable development and protection.