Abstract-Emphasizing wide application potential of designing of ultra-low power instrumentation, a dynamic reconfigurable SoC is designed, wherein Analog and Mixed Signal (AMS) based VLSI design is employed. Measurement of concentration of Dissolved Oxygen (DO) and its temperature dependence is essential for typical chemical processes. Therefore, present prototype is designed using Programmable System on Chip (PSoC) for monitoring of the temperature compensated DO concentration. The Clark's Polarographic cell and semiconductor temperature sensor wired off-chip deploying the SoC is designed about Cypress PSoC5. Here, excluding sensors, the system is designed on single chip. By reconfiguration of highly featured on-chip resources such as voltage source, operational amplifiers, analog multiplexer, programmable gain amplifier, delta-sigma ADC, LCD block, etc., and on integration of the same by Cypress PSoC Creator, an Integrated Development Environment (IDE), the design of SoC is realized. The low power on-chip VDAC for excitation of the DO cell. Analog signals from both DO and temperature are multiplexed on-chip. The preciseness of SoC is achieved configuring ƩΔADC having 10-bit resolution. The developed system is calibrated to the standard temperature and DO units against the standard electronic meter. On implementation it is found the DO is not only sensitive to the temperature but also for atmospheric pressure. Results are interpreted in this paper.