Trend in gastric cancer: 35 years of surgical experience in Japan

Yamashita, Keishi; Sakuramoto, Shinichi; Nemoto, Masayuki; Shibata, Tomotaka; Mieno, Hiroaki; Katada, Natsuya; Kikuchi, Shiroh; Watanabe, Masahiko

doi:10.3748/wjg.v17.i29.3390

Cited by 59 publications

(51 citation statements)

References 20 publications

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“…However, GC is often asymptomatic during its early stage, which results in the advanced stage being generally refractory to those therapies (8). Even following radical gastrectomy, many patients experience disease recurrence and succumb to the disease within a few months to years; the 5-year survival rate of GC is ≤2/3 (9,10).…”

Section: Introductionmentioning

confidence: 99%

Molecular dysexpression in gastric cancer revealed by integrated analysis of transcriptome data

Dong

et al. 2017

Oncology Letters

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Abstract. Gastric cancer (GC) is often diagnosed in the advanced stages and is associated with a poor prognosis. Obtaining an in depth understanding of the molecular mechanisms of GC has lagged behind compared with other cancers. This study aimed to identify candidate biomarkers for GC. An integrated analysis of microarray datasets was performed to identify differentially expressed genes (DEGs) between GC and normal tissues. Gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were then performed to identify the functions of the DEGs. Furthermore, a protein-protein interaction (PPI) network of the DEGs was constructed. The expression levels of the DEGs were validated in human GC tissues using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). A set of 689 DEGs were identified in GC tissues, as compared with normal tissues, including 202 upregulated DEGs and 487 downregulated DEGs. The KEGG pathway analysis suggested that various pathways may play important roles in the pathology of GC, including pathways related to protein digestion and absorption, extracellular matrix-receptor interaction, and the metabolism of xenobiotics by cytochrome P450. The PPI network analysis indicated that the significant hub proteins consisted of SPP1, TOP2A and ARPC1B. RT-qPCR validation indicated that the expression levels of the top 10 most significantly dysexpressed genes were consistent with the illustration of the integrated analysis. The present study yielded a reference list of reliable DEGs, which represents a robust pool of candidates for further evaluation of GC pathogenesis and treatment.

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Section: Introductionmentioning

confidence: 99%

Molecular dysexpression in gastric cancer revealed by integrated analysis of transcriptome data

Dong

et al. 2017

Oncology Letters

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“…The same pre-specified questionnaire was given to the patients in the outpatient center, 3,6,9,12,18,24,36,48, and 60 months after surgery. The physicians asked patients to check the symptoms in the questionnaire during their outpatient clinic visit, but a third person did not check for symptom validity, so these symptom reports were subjective.…”

Section: Questionnairementioning

confidence: 99%

“…The mainstay of treatment is curative surgery, with open gastrectomy combined with lymph node dissection, the standard approach for gastric tumor resection [2]. In recent years, the number of operations for gastric cancer, particular early tumors, has increased as a result of advances in diagnostic techniques [3,4]. The use of laparoscopy-assisted gastrectomy including laparoscopy-assisted distal gastrectomy (LADG), described in Japan in 1994 for early (cT1) gastric cancer [5], is becoming widely accepted [4][5][6][7], because it offers excellent clinical outcomes in the short and long term.…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic versus open distal gastrectomy for early gastric cancer in Japan: long-term clinical outcomes of a randomized clinical trial

et al. 2015

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“…The incidence of adenocarcinoma of the esophago-gastric junction (EGJ) is increasing in Western (1,2) and Eastern (3)(4)(5) countries. By contrast, the prevalence of squamous cell carcinoma (SCC) remains increased in Japan compared with Western countries.…”

Section: Introductionmentioning

confidence: 99%

Prognoses of advanced esophago‑gastric junction cancer may be modified by thoracotomy and splenectomy

et al. 2017

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Abstract. Globally, the incidence of esophago-gastric junction (EGJ) cancer is rapidly increasing. However, the proposed strategies for the treatment of these types of cancer are so diverse that there is no established consensus on the optimal treatment. The aim of the present study was to identify independent prognostic factors to delineate the optimal strategies for the treatment of EGJ cancer. The medical records of 150 patients with EGJ cancer who underwent curative surgery at the Kitasato University were retrospectively reviewed. The median follow-up period was 48 months. The patients with tumors that were classified as post-treatment primary tumor stage 3 [(y)pT3] or higher had a 5-year disease-specific survival (DSS) rate of 53%, whereas those with tumors that were classified as (y)pT0-2 had a 5-year DSS rate of 90%. Therefore, prognostic analysis was restricted to those tumors that were designated (y)pT3 or higher. A multivariate Cox's proportional hazards model identified the following independent prognostic factors that negatively influenced the DSS: i) Presence of tumors classified as post-treatment regional lymph node stage 1-3 [(y)pN1-3] [hazard ratio (HR), 3.62; 95% confidence interval (CI), 1.39-12.36]; ii) not undergoing treatment with splenectomy (HR, 2.40; 95% CI, 1.15-5.15); and iii) undergoing treatment with thoracotomy (HR, 2.07; 95% CI, 1.02-4.23). In patients with (y)pN0 tumors, the DSS rate was significantly improved for those who underwent splenectomy than for those who did not (P=0.024). In patients with (y)pN1-3 tumors, the DSS rate was significantly worse for those who underwent thoracotomy compared with those who did not (P=0.004). Splenectomy and thoracotomy may critically affect prognosis in locally advanced EGJ cancer that are classified as (y)pN0 and (y)pN1-3, respectively. Surgical treatments require optimization in order to improve prognoses in advanced EGJ cancer.

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Trend in gastric cancer: 35 years of surgical experience in Japan

Abstract: In Japan, planned interventions may improve surgical gastric cancer mortality, but an unexpected trend of persistent existence of intestinal type cancer suggests the need for more robust medical intervention.

Cited by 59 publications

References 20 publications

Molecular dysexpression in gastric cancer revealed by integrated analysis of transcriptome data

Molecular dysexpression in gastric cancer revealed by integrated analysis of transcriptome data

Laparoscopic versus open distal gastrectomy for early gastric cancer in Japan: long-term clinical outcomes of a randomized clinical trial

Prognoses of advanced esophago‑gastric junction cancer may be modified by thoracotomy and splenectomy

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