Background: World Health Organization (WHO) estimates that, globally more than three million of acute poisoning cases with 2,20,000 deaths occur annually. Of these, 90% of fatal poisoning occurs in developing countries particularly among agricultural workers. It has been reported that acute poisoning approximately constitutes 10% of admission in medical emergency departments in India. Objectives: 1. To assess the patterns of socio-demographic variables of patients admitted with acute poisoning in a rural tertiary care hospital 2. To determine the various poison related factors in relation to the outcome of patients admitted with acute poisoning in a rural tertiary care hospital of Nalgonda district. Methodology: This was a retrospective record based study conducted using patient's discharge summaries comprising of the patients admitted to the emergency medicine department for acute poisoning from July 2019 to January 2020. Data was entered and analyzed using Microsoft Excel 2010. Results: During the study period, a total of 77 acute poisoning cases were admitted, with 5 deaths, resulting in a mortality rate of 6.5%. Acute poisoning was most seen in males (58.4%) and in the 14 to 30 years (62.3%) age group. Majority of the patients were admitted for ingestion of poison (89.6%) and the most commonly consumed poison was insecticides (40.3%). Conclusion: Insecticide poisoning is the most common form of poisoning with high mortality among males. There is a need for appropriate training and counselling sessions of preventive strategies for individuals who are at risk of acute poisoning especially the younger age groups.