Background: Kanpur is not only the biggest city of the Uttar Pradesh but also 9th most populated city of the India and is the main centre of commercial and industrial activities. Kanpur is situated at the bank of holy river Ganga. It is very crowded city and facing the problems of population influx from neighboring towns and villages. Apart from fame for industry, Kanpur lies between two rivers Ganga and Pandu. The land of Kanpur district is plain and fertile with Cultivable Barren Land 185480 Hectare. Kanpur is an only notified metropolitan area by UP Government under Code of Criminal Procedure 1973, and therefore has a Chief Metropolitan Magistrate. Poisoning is an important public health issue in India and worldwide. The present study is aimed to assess the epidemiological variables of fatal poisonings in Kanpur.Methods: All medico legal autopsies of the city were conducted in the GSVM Medical College mortuary, Kanpur. During the study period, 582 cases of fatal poisoning were autopsied. Only autopsies with confirmed diagnosis of poisoning were included in this prospective study.Results: A total of 7648 medico legal autopsies were performed at the aforementioned centre. Poisoning deaths comprised 582 cases (7.6%) of the total autopsies conducted during the study period.Conclusions: Suicidal poisoning is accountable for majority of poisoning deaths in India. Societies at large owe a collective responsibility to this manner of death and mere condemnation or sympathy is not sufficient to curb these avoidable deaths.

Introduction: When girls get married, this heralds a major change in their immediate environment. There is a change of guardianship, separation from the parents and family and creation of a new family. All this creates a stressful environment around them, which is further aggravated by pregnancy, the upbringing of children, managing the household and office works. Eventually, when the tolerance breaks down, the brides are forced to take the extreme step of ending their miserable lives. In the majority of female unnatural deaths, the family members (parents, husbands, in-laws) may be directly or indirectly responsible for precipitating the circumstances leading to the death of the victim.Methodology: Material for the present study comprised of all information from the relatives, guardians, police or investigating officers pertaining to the cases of 'unnatural deaths of females within seven years of their marriage', brought to the District Mortuary, Kanpur during the period of one year. Conclusion:The incidence of unnatural deaths in females who died within seven years of their marriage was estimated to be 4.17% of the total cases autopsied. Maximum numbers of victims were rural Hindu housewives belonging to lower-middle or middle socioeconomic classes between 18-22 years of age and most of them had died within three years of their marriage. In cases of homicidal deaths burning and throttling/strangulation were found as the most common method used Dowry was the most common motive in homicidal deaths. As such husbands and in-laws were the most common human offenders in homicidal cases. Hanging was the most common method used in suicidal cases followed by burning. Whereas family quarrel and marital disharmony were the most common motives behind such deaths.

CONTEXT- Histopathological examination of oral premaligant and malignant lesions, presenting the fundamental aspects of this cancer, focused on squamous cell carcinoma of the oral cavity (OSCC), moving from its denition and epidemiological aspects, addressing the oral carcinogenesis, oral potentially malignant disorders, epithelial precursor lesions and experimental methods for its study, therapies and future challenges. Also immunoexpression of genes p53 and bcl2 attributed in pathogenesis of development of oral cancer. AIMS- Histopathological analysis of oral premalignant and malignant lesions and immunoexpression of Bcl 2 and p53 in these lesions. MATERIAL AND METHODS- This study was done in department of pathology, GSVM medical college, Kanpur. This was prospective study done from 2019-2021. A total of 200 cases were studied. Specimen received were xed in 10% formalin, processed and sections of 3-4 micron were prepared, stained with H and E. Histopathological examination was done. Anti p53, anti bcl2 antibody was used. Staining and evaluation of immunohistochemistry was done using Ab-5 (clone DO-7) ready to use as monoclonal primary antibody. RESULTS- th Maximum number of cases [24%] were in their 4th and 5 decades of life. Males predominated over females with male:female ratio of 3:1. In present study the most common site of oral mucosal lesions was buccal mucosa which accounted for 42% of total cases. . 88% cases had history of tobacco use, this data strongly suggest close association between tobacco and oral cancer. Most of the pre-neoplastic and neoplastic lesions of oral cavity & oropharynx occur after 20-30 years of exposure to tobacco (37%), followed by 27% each after 0-20 years and 30-40 years of exposure. Gutkha chewing (tobacco) was the commonest observed in almost 50% cases. 69.5%belong to rural areas whereas only 30.5% cases were belong to urban areas. . Among premalignant cases, majority were of leukoplakia (30%) cases.Majority of the malignant cases were well differentiated squamous cell carcinoma. [23%]. Expression of p53 was found in 772.8% of the pre-malignant cases and 90.7% of the malignant lesions of the oral cavity. . It was found that 54.34% of premalignant lesions and 66.6% of malignant lesions showed strong p53 positivity. Most of the premalignant lesion showed mild positivity [50%]. 35% cases showed moderate positivity while none of the premalignant cases showed strong positivity. 52% cases of malignant lesions showed weak positivity. 45% cases showed moderate positivity and 13% had strong positivity. Intensity of staining increases with increasing grade of dysplasia and cancer. CONCLUSION- Pro apoptotic and anti apoptotic genes like p53 and bcl2 play an important role in early pathogenesis of oral cancer and their development from premalignant to malignant lesions. However, they are not the only genes involved as their tumorigenesis seemsmultifactorial.Targettedstudy towards thesegenes canstillbringfutureprospectsofgenetherapy tolight.