Trends and Causes of Congenital Anomalies in the Pleven Region, Bulgaria

Kovacheva, K; Simeonova, M; Velkova, A

doi:10.2478/v10034-009-0007-7

Cited by 7 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the numbers for the malformations of the specific body system were small for any statistical power in the analysis. Similar observations have been made in other long-term studies from the developed countries [ 7 , 13 , 22 , 30 , 31 , 35 ]. There were no long-term population based studies from the English speaking Caribbean region available for comparison.…”

Section: Discussionsupporting

confidence: 90%

“…The present study demonstrates a significant increase in the prevalence of MCMs when the prevalence rate for the period 1993 to 2002 was compared with those from the period 2003-2012. Long-term studies from other countries have reported varying secular trends in the prevalence of CMs [ 7 , 13 , 22 , 30 , 31 , 35 ]. Studies from UK and the USA have reported an overall decreasing trend and have attributed the decline to increasing prenatal diagnosis and termination of pregnancy in addition to the factors mentioned above [ 22 , 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Major Congenital Malformations in Barbados: The Prevalence, the Pattern, and the Resulting Morbidity and Mortality

Singh

Krishnamurthy

Greaves

et al. 2014

ISRN Obstetrics and Gynecology

View full text Add to dashboard Cite

Objectives. To study the prevalence and the pattern of major congenital malformations and its contribution to the overall perinatal morbidity and mortality. Methods. It is a retrospective population based study. It includes all major congenital malformations in newborns during 1993-2012. The data was collected from the birth register, the neonatal admission register and the individual patient records at the Queen Elizabeth Hospital where over 90% of deliveries take place and it is the only facility for the care of sick newborns in this country. Results. The overall prevalence of major congenital malformations among the live births was 59/10,000 live births and that among the stillbirths was 399/10,000 stillbirths. Circulatory system was the most commonly affected and accounted for 20% of all the major congenital malformations. Individually, Down syndrome (4.1/10, 000 live births) was the commonest major congenital malformation. There was a significant increase in the overall prevalence during the study period. Major congenital malformations were responsible for 14% of all neonatal death. Conclusions. Less than 1% of all live newborns have major congenital malformations with a preponderance of the malformations of the circulatory system. Major congenital malformations contribute significantly to the overall neonatal morbidity and mortality in this country.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Major Congenital Malformations in Barbados: The Prevalence, the Pattern, and the Resulting Morbidity and Mortality

Singh

Krishnamurthy

Greaves

et al. 2014

ISRN Obstetrics and Gynecology

View full text Add to dashboard Cite

show abstract

“…In the current review, the pooled proportion of chromosomal disorders in Africa was 8.94 (CI: 7.02, 10.86: I 2 : 98.8%; p < 0.001). The result of this meta analyses is comparable with a large-scale study conducted in Bulgaria: in which the proportion of chromosomal disorders was 8.2% among births with congenital anomalies [ 97 ]. The current result is higher compared to the study conducted in industrialized nations, in which only 6% of chromosomal disorders accounted for among births with congenital anomalies [ 98 ].…”

Section: Discussionsupporting

confidence: 82%

Proportion of Chromosomal Disorders and Their Patterns among Births with Congenital Anomalies in Africa: A Systematic Review and Meta-Analyses

Gebremeskel

Gedion

2022

The Scientific World Journal

View full text Add to dashboard Cite

Introduction. Worldwide, surveys have shown that the frequency of chromosomal disorders among births with congenital anomalies varies greatly from country to country. It is well known that chromosomal disorders are an important cause of premature death or life-long disability; however, the absence of local epidemiological data on their birth prevalence and outcomes impedes policy and service development in many countries and continents. Therefore, the current systematic review and meta-analysis intend to show the pooled proportion of chromosomal disorders among births with congenital anomalies in Africa. Methods. From PubMed, Cochrane Library, and Google Scholar, we systematically reviewed and meta-analyzed the studies that examined the incidence, prevalence, and types of chromosomal disorders using PRISMA guidelines. A weighted inverse variance random-effects model was used to estimate the pooled proportion of chromosomal disorders among births with congenital anomalies. Results. From the total of 3,569 studies identified, 1,442 were from PubMed, 108 were from Cochrane Library, 1,830 were from Google Scholar, and 189 were from other sources. After duplication was removed, a total of 844 articles remained (2725 were removed by duplication). Finally, 144 full-text studies were reviewed and 60 articles with 52,569 births having congenital anomalies met the inclusion criteria and were selected for this meta-analysis. The pooled proportion of chromosomal disorders among births with congenital anomalies was 8.94% (95% CI; 7.02, 10.86; I2 = 98.8%; p < 0.001 ). Conclusions and Future Implications. In the current systematic review and meta-analysis, the pooled proportion of chromosomal disorders among births with congenital anomalies in Africa was small. Down syndrome (trisomy 21) accounted for more than 80% of chromosomal disorders. The pooled proportion of chromosome disorders was the highest in North African regions and countries compared to other regions of the continent. Healthcare managers should focus on establishing proper cytogenetic diagnostic facilities in collaboration with well-trained genetic counseling services in the continent.

show abstract

“…8,9 The study of missing frequency of congenital cardiac anomalies will be important in planning for prevention strategies, medical care, and surgical treatment of newborn babies. 10,3 Infants with congenital cardiac diseases may not even be diagnosed until a paediatric cardiologist visits them for some other medical reasons. 11,12 The aim of this study was to estimate the missing frequency of congenital cardiac anomalies at the time of delivery or after birth.…”

mentioning

confidence: 99%

“…Early diagnosis and screening of congenital cardiac anomalies is vital because the lack of proper diagnosis of congenital cardiac malformation will result in a high risk of mortality in children and decrease life expectancy of newborn infants 8 , 9 . The study of missing frequency of congenital cardiac anomalies will be important in planning for prevention strategies, medical care, and surgical treatment of newborn babies 10 , 3 . Infants with congenital cardiac diseases may not even be diagnosed until a paediatric cardiologist visits them for some other medical reasons 11 , 12 .…”

mentioning

confidence: 99%

Early diagnosis and screening of congenital cardiac anomalies

2010

View full text Add to dashboard Cite

Considerable numbers of congenital cardiac anomalies are missed at the time of delivery. Study reports show that congenital cardiac anomalies are the second most common birth defect in many countries. Despite this fact, our previous study showed that the prevalence of congenital cardiac anomalies is the fifth most common one, indicating that many of these defects might not be properly diagnosed at the time of delivery and birth. The aim of this study was to estimate the missing frequency of congenital cardiac anomalies at the time of delivery and birth. The population of the study was 185,650 births in the Northwest region of Iran covered by the Tabriz Registry of Congenital Anomalies. A total of 451 children with congenital cardiac anomalies were studied in the region from 2000 to 2009. The expected prevalence of congenital cardiac anomalies at birth was estimated to be 24.2 per 10,000 births while a prevalence of 9.2 per 10,000 births was observed at the same time and place. This indicated that 59.1% of children with congenital cardiac anomalies were not identified at birth (p-value less than 0.05). This proportion increased by 13% over the study period from 2000 to 2009 (p-value greater than 0.1). Our findings indicated that a remarkable frequency of congenital cardiac anomalies was not diagnosed at birth because there was no paediatric cardiologist available at the time of birth in the gynaecology and obstetrics wards.

show abstract

Trends and Causes of Congenital Anomalies in the Pleven Region, Bulgaria

Cited by 7 publications

References 15 publications

Major Congenital Malformations in Barbados: The Prevalence, the Pattern, and the Resulting Morbidity and Mortality

Major Congenital Malformations in Barbados: The Prevalence, the Pattern, and the Resulting Morbidity and Mortality

Proportion of Chromosomal Disorders and Their Patterns among Births with Congenital Anomalies in Africa: A Systematic Review and Meta-Analyses

Early diagnosis and screening of congenital cardiac anomalies

Contact Info

Product

Resources

About