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Introduction: In the Sverdlovsk Region, the risks posed by cadmium, arsenic and lead exposures account for higher disease rates in the most sensitive groups of population. Recent studies have shown that these toxicants have an effect on mineral metabolism, damage to liver cells, kidneys, immunity indicators, and the nervous system. Objective: To assess the levels of cadmium, lead and arsenic in biological fluids of preschool children aged 3–6 years, living in towns with developed non-ferrous metallurgy, and possible changes in the health status at the detected level of toxicity. Materials and methods: The study was conducted in six towns of the Sverdlovsk Region with developed non-ferrous metallurgy. Environmental pollution in the study areas was assessed based on data of socio-hygienic monitoring. Biological monitoring was carried out to establish the levels of toxicants in blood and urine of children. A descriptive analysis of chronic morbidity in preschool children was performed, and the results of a special health examination of children (including that by a pediatrician and a neurologist) were presented. Mathematical modeling using decision trees was carried out. Results: Health monitoring data indicate an excess of the average regional prevalence rates in the studied preschoolers in nine disease categories. According to the results of an in-depth examination of the preschool children, diseases of the skin and subcutaneous tissue, diseases of the respiratory system, blood diseases and individual disorders involving the immune mechanism, and digestive diseases prevailed. Among concomitant diseases, the most prevalent were diseases of the digestive, nervous, and respiratory systems. Assessment of the neurological status showed that the largest percentage of children had residual cerebral insufficiency, attention deficit hyperactivity disorder, and cerebrastenic syndrome. Biomonitoring results indicated a higher level of lead, arsenic and cadmium in the biological fluids of those children. Mathematical modeling demonstrated statistically significant correlations between lead, cadmium, and arsenic concentrations in environmental objects, biomonitoring results, and clinical and laboratory examination data of children (the blood levels of alanine aminotransferase, zinc, total protein, phagocytic index, and the carrier of the marker of apoptosis CD95+). Conclusions: The results of biological monitoring were consistent with data on chronic morbidity in preschool children. Modeling data provided the body burden of toxicants, above which deviations of clinical and laboratory parameters from the reference values may occur. The findings can be used in implementation of targeted measures for disease prevention.
Introduction: In the Sverdlovsk Region, the risks posed by cadmium, arsenic and lead exposures account for higher disease rates in the most sensitive groups of population. Recent studies have shown that these toxicants have an effect on mineral metabolism, damage to liver cells, kidneys, immunity indicators, and the nervous system. Objective: To assess the levels of cadmium, lead and arsenic in biological fluids of preschool children aged 3–6 years, living in towns with developed non-ferrous metallurgy, and possible changes in the health status at the detected level of toxicity. Materials and methods: The study was conducted in six towns of the Sverdlovsk Region with developed non-ferrous metallurgy. Environmental pollution in the study areas was assessed based on data of socio-hygienic monitoring. Biological monitoring was carried out to establish the levels of toxicants in blood and urine of children. A descriptive analysis of chronic morbidity in preschool children was performed, and the results of a special health examination of children (including that by a pediatrician and a neurologist) were presented. Mathematical modeling using decision trees was carried out. Results: Health monitoring data indicate an excess of the average regional prevalence rates in the studied preschoolers in nine disease categories. According to the results of an in-depth examination of the preschool children, diseases of the skin and subcutaneous tissue, diseases of the respiratory system, blood diseases and individual disorders involving the immune mechanism, and digestive diseases prevailed. Among concomitant diseases, the most prevalent were diseases of the digestive, nervous, and respiratory systems. Assessment of the neurological status showed that the largest percentage of children had residual cerebral insufficiency, attention deficit hyperactivity disorder, and cerebrastenic syndrome. Biomonitoring results indicated a higher level of lead, arsenic and cadmium in the biological fluids of those children. Mathematical modeling demonstrated statistically significant correlations between lead, cadmium, and arsenic concentrations in environmental objects, biomonitoring results, and clinical and laboratory examination data of children (the blood levels of alanine aminotransferase, zinc, total protein, phagocytic index, and the carrier of the marker of apoptosis CD95+). Conclusions: The results of biological monitoring were consistent with data on chronic morbidity in preschool children. Modeling data provided the body burden of toxicants, above which deviations of clinical and laboratory parameters from the reference values may occur. The findings can be used in implementation of targeted measures for disease prevention.
Introduction. The fulfillment of effective measures to manage the level of dust pollution in the atmospheric air of settlements requires correct hygienic assessments of the situation and reliable data on the sources of particulate emissions. The purpose of the study was to substantiate what is need to take into account the entire set of solid emitted components when conducting hygienic assessments of the situation, including the consideration and approval of draft standards for permissible emissions and projects of sanitary protection zones. Materials and methods. On the example of a large industrial enterprise, calculations of the dust emissions dispersion were made with and without taking into account the total mass of solid components. Source parameters are taken according to the enterprise inventory list. Dispersion calculations were carried out using the standardized program “Ecolog-City”. Results. For each individual solid substance at the border of the sanitary protection zone and at the points of the nearest housing no violations of hygienic standards were established to be recorded. The situation was characterized as normative, not requiring measures to improve the safety of the population. The total release of the solid component of emissions (TSP) created an excess of the hygienic standard for the group “suspended substances” (0.5 mg/m3) at the border of the sanitary protection zone. The zone of excess pollution (more than 1 MPC) extended to the residential area. The level of pollution calculated from the totality of solid substances was satisfactorily corresponded with the data of instrumental measurements. Limitations. The limitation of the study is related to the fact that the obtained results characterize a particular enterprise, however, the principal approaches used can be applied to any similar studies. Conclusion. It seems appropriate to harmonize the concept of “suspended matter” with the definition adopted by the World Health Organization, establishing that suspended matter is the total amount of solid particles of organic and inorganic substances. Fixing such a concept in sanitary rules and regulations ensures the correctness of the hygienic assessment of the situation, the comparability of calculated and natural data, the absence of contradictions between the established emission standards for each type of dust and the results of a health risk assessment (performed taking into account the sum of all particulate matter). The use of MPCs for various types of dust remains an important tool for identifying emission sources and preventing the negative impact of dusts with carcinogenic or highly toxic properties.
Introduction. Ambient air pollution determines high levels of risk to public health, causing excess mortality. The purpose of the study is to analyze the dependence of the seasonal dynamics of pollutants and mortality from major non-infectious diseases in the population of the industrial center of Eastern Siberia. Materials and methods. Air pollution in Bratsk was assessed based on data from monitoring systems for 2017–2022, taking into account one-time, average monthly and annual concentrations. Hazard indices and mortality rates (MR) from major causes were calculated. The annual trend in indicators are assessed using seasonality indices (SI). Results. Features of the seasonal dynamics of pollutants were revealed: maximum fluctuations in SI are characteristic of benzo(a)pyrene (22% in the warm season, 214% in the cold season), formaldehyde (219 and 65%, respectively). The SI for mortality had significant fluctuations throughout the year and varied across age groups and disease classes. Changes in seasonality have been noted during the COVID-19 pandemic. Average monthly MR in the older group is associated with concentrations of PM2.5, formaldehyde, NO2. Limitations of the study are related to the limited data on monitoring pollutants, inevitable errors in conditional division into seasons, and the impossibility of accurately determining the cause of death during a pandemic. Conclusion. The use of average monthly data on MR values and pollutant concentrations confirms the dependence of population mortality on air pollution when studying this phenomenon in medium-sized cities with high levels of hazard indices.
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