Trends in antibiotic susceptibility of enteric fever isolates among children attending a tertiary care hospital of Peshawar, KP

Ahmad, Samreen; Zahid, Shahzada Bakhtyar; Salahuddin, Abid; Khan, Ameer; Khan, Muhammad Asim; Ali, Husnul Maab

doi:10.52442/jrmi.v6i3.186

Cited by 3 publications

(5 citation statements)

References 9 publications

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“…In addition, we are also trying to predict whether there will be sensitivity of intestinal pathogens to conventional first-line drugs reappears drug. 7 Despite the fact that there was no relation among gender overall illness incidence, our research observed that male had a greater incidence of cases (68%) than females (32%). Previous studies have indicated a somewhat different biological sex ratio which the incidence rate of male was (50.1%) and the incidence rate in female was (47.5%) (Peer et al 2021).…”

Section: Discussioncontrasting

confidence: 62%

“…It is primarily cause of local intestinal inflammation, diarrhea and intestinal perforation etc. 7 Upon ingestion into the body, its active replication takes place 7 to 10 days. After that they invade the epithethelial cell of the small intestine, which spread in mesenteric lymph nodes and hepatic cells through the portal vein.…”

Section: Introductionmentioning

confidence: 99%

“…According to World Health Organization, In Pakistan, annually 412 individuals get infected with typhoid fever in every 100,000 cases. 7 The aim of this study was to identify unique differences in antibiotic susceptibility across Salmonella typhi isolates isolated from human blood samples, providing insight into critical patterns impacting successful treatment approaches.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of <i>Salmonella typhi </i>in Blood Cultures and Antibiogram Patterns in Peshawar

Ahmad,

Sanab,

Inayat

et al. 2023

NJLHS

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Background: Typhoid fever, caused by Salmonella typhi, has become a major public health problem worldwide, particularly in developing nations like Pakistan, as a result of the emergence of resistant strains. The aim of this study was to identify unique differences in antibiotic susceptibility across Salmonella typhi isolates isolated from human blood samples, providing insight into critical patterns impacting successful treatment approaches. Methodology: 2000 patients’ blood samples collect whose sign and symptom like typhoid positive individuals were cultured on blood agar and MacConkey agar to detect Salmonella typhi. Biochemical assays were used to identify the bacterium, and the disc diffusion method on MHA agar was used to evaluate its susceptibility to eleven antibiotics. Results: Salmonella typhi (5%) was identified from patients' blood samples. Ciprofloxacin resistance was found in 32% of those tested, followed by resistance to azithromycin (41%), ceftazidime (87%), cefotaxime (88%), sulactum/cefoperazone and piperacillin/tazobactam (89%), and chloramphenicol (97%) and Tigecycline, Imipenem, Gentamicin and Amikacin along with Meropenem shows 0% resistance toward bacterium otherwise there was no Funding. Conclusion: According to our findings, Salmonella typhi very rapidly developing resistance to antimicrobial drugs as a result of virulence transfer and antibiotic resistance, this might lead to treatment failure in typhoid patients in Pakistan.

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Section: Discussioncontrasting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence of <i>Salmonella typhi </i>in Blood Cultures and Antibiogram Patterns in Peshawar

Ahmad,

Sanab,

Inayat

et al. 2023

NJLHS

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“…Moreover, state-of-the-art technologies like VITEK MS provided precision in identification, with biochemical reactions and Gram staining fortifying the characterization process. Species identification and antibiotic susceptibility were ascertained using VITEK 2 Compact (18). A comparative analysis with a study from tertiary care centers in Faisalabad and Lahore, Pakistan, further illuminated the A. baumannii landscape.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Aminoglycoside-Resistant Acinetobacter baumannii in Respiratory Specimens: Phenotypic and Molecular Insights

Safdar,

Mustafa,

Aziz

et al. 2024

JHRR

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Background: The global rise of antibiotic-resistant bacteria presents a formidable challenge to healthcare systems, with Acinetobacter baumannii standing out as a particularly resilient pathogen in hospital settings. The propensity of this organism to exhibit multidrug resistance complicates treatment protocols and underscores the need for in-depth research into its resistance mechanisms. Objective: The objective of this study was to characterize the allelotypic and molecular features of aminoglycoside-resistant Acinetobacter baumannii isolates from respiratory specimens and to determine their antibiotic susceptibility profiles to inform better clinical decision-making and treatment approaches. Methods: This cross-sectional study was conducted at the different labs of various institute of Lahore. A total of 50 respiratory specimens were cultured on selective media. The isolates underwent phenotypic characterization through colony morphology and biochemical tests. Antimicrobial susceptibility was assessed using the disc diffusion method, and molecular analysis was performed using polymerase chain reaction (PCR) to identify the armA gene associated with aminoglycoside resistance. Statistical analysis was executed using SPSS Version 25. Results: Of the 50 isolates, 54% were from male patients and 46% from female patients. Antibiotic resistance was alarmingly high, with resistance rates of 92% for TZP, 90% for FEP, CAZ, IPM, MEM, 86% for AK, 74% for CN, 54% for TOB, and 48% for DO. The presence of the armA gene was detected in 86% of the isolates, suggesting a link to the high levels of aminoglycoside resistance observed. Conclusion: The study revealed a high prevalence of multidrug-resistant Acinetobacter baumannii in respiratory specimens, with significant resistance to commonly used antibiotics. These findings highlight the necessity for continuous surveillance of antibiotic resistance patterns and call for innovative approaches to antimicrobial therapy.

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“…Its temporal scope from January 2023 to July 2023 reflects a devoted effort to capture a complete view of antibiotic sensitivity patterns in typhoid fever sufferers, losing light on capacity shifts in resistance over the years. Acknowledging the severity of typhoid fever, the study's emphasis on antibiotic susceptibility is essential in guiding appropriate healing interventions (Ahmad et al, 2020;Saito et al, 2022). As underscored by the Centers for Disease Control and Prevention (CDC), the emergence of multidrug-resistant (MDR) and drastically drug-resistant (XDR) lines of Salmonella typhi poses a powerful venture to the effective management of typhoid fever (Maharjan et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Pattern of Antibiotic Sensitivity in Typhoid Fever Patients With Positive Blood Culture: An Observational Study

KHAN,

BASIT

et al. 2024

Biol Clin Sci Res J

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Salmonella typhi is a type of bacteria that can cause typhoid fever, a severe infection that primarily affects people in developing countries. It is a significant public health concern. An antibiogram test was conducted by the Department of Medicine at MTI, LRH Peshawar, to test antibiotic susceptibility in samples that tested positive for typhoid culture from January 2023 to July 2023. The Kirby-Bauer disk diffusion method was used to evaluate the antibiotic susceptibility of Salmonella isolates on Mueller-Hinton agar. IBM SPSS version 22 was used to analyze all of the data. In total, 90 people participated in the research, with 40 percent being female and 50 percent male. Of the Salmonella isolates, 08 (28.20%) were sensitive to typhoid, 18 (68.80%) were MDR, and 01 (04%) were XDR. Of the 27 isolates, 6 (21.40%) showed Ampicillin sensitivity, while 21 (81.40%) showed resistance to the antibiotic. 90.20% of the isolates were resistant to chloramphenicol, while 15.60% were susceptible. 60.20% of the isolates were resistant to ceftriaxone, while 41.40% showed sensitivity to the drug. Nine isolates (30.40%) showed sensitivity to ciprofloxacin, while eighteen isolates (68.40%) showed resistance. 26 27 isolates (91.40%) showed sensitivity to azithromycin, while 01 (02.40%) showed resistance. Meropenem was the most effective antibiotic, with 100% of the isolates exhibiting Meropenem sensitivity. Based on the findings, azithromycin and meropenem are the most effective antibiotics against isolates of Salmonella spp. MDR and XDR strains of enteric fever are on the rise and exhibit a high degree of resistance to commonly prescribed medications. Antibiotic use without a prescription should be minimized, and prescribing practices should be modified.

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Trends in antibiotic susceptibility of enteric fever isolates among children attending a tertiary care hospital of Peshawar, KP

Cited by 3 publications

References 9 publications

Incidence of <i>Salmonella typhi </i>in Blood Cultures and Antibiogram Patterns in Peshawar

Incidence of <i>Salmonella typhi </i>in Blood Cultures and Antibiogram Patterns in Peshawar

Characterization of Aminoglycoside-Resistant Acinetobacter baumannii in Respiratory Specimens: Phenotypic and Molecular Insights

Pattern of Antibiotic Sensitivity in Typhoid Fever Patients With Positive Blood Culture: An Observational Study

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