Trends in conjunctivochalasis research from 1986 to 2017

Zhao, Yanqing; Huang, Li; Xiang, Minhong; Li, Qingsong; Wang, Miao; Lou, Zhengchi

doi:10.1097/md.0000000000012643

Cited by 12 publications

(9 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 In recent decades, studies related to CCH have gradually increased. 5 Researchers have speculated in a variety of ways in implicating the pathogenesis of CCH. For example, degenerative structural changes, especially elastotic degeneration and collagenolysis by overexpression of matrix metalloproteinases (MMPs), have long been speculated to contribute to the pathogenesis of CCH.…”

mentioning

confidence: 99%

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

Xiang

Zhan

et al. 2019

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

PURPOSE. Conjunctivochalasis (CCH) is a common ocular disease and has received extensive attention recently. However, its exact pathogenesis remains largely unknown. Owing to the high morbidity of CCH in older people, this study aimed to investigate whether cellular senescence contributes to CCH progression and the underlying mechanism. METHODS. Loose conjunctival tissues from CCH patients (n ¼ 13) and normal conjunctival tissues from age-matched persons (n ¼ 12) were obtained and the fibroblasts were separately induced and obtained. Cellular senescence, and the expression of senescence-associated genes (p53 and p21) and p38 in CCH conjunctival tissues and normal controls, were determined by senescence-associated b-galactosidase (SA-b-Gal) staining and quantitative (q)RT-PCR, respectively. To explore the effects of p38 on cellular senescence in CCH fibroblasts, small interfering RNA (siRNA) targeting p38 (siP38) and p38-specific inhibitor SB203580 was performed in CCH fibroblasts. Then, cellular senescence, cell viability, reactive oxygen species (ROS) production, and gene expression were detected according to the corresponding methods. RESULTS. CCH conjunctival tissues had significantly more senescent cells, evidenced by more SA-b-Gal-positive cells, and higher expression of senescence-associated genes (p53 and p21) and p38. CCH fibroblasts transfected with siP38 or treated with SB203580 had obviously reduced numbers of senescent cells, decreased ROS production, and increased cell viability, as well as reduced expression of senescence-associated genes. Meanwhile, blocking p38 signaling decreased the expression of p53 and p21. CONCLUSIONS. Therefore, these findings indicate that cellular senescence might be a causative factor for CCH. P38 signaling might play an important role in the progress of cellular senescence in CCH fibroblasts via manipulation of p53/p21 signaling.

show abstract

mentioning

confidence: 99%

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

Xiang

Zhan

et al. 2019

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…At the same time, search for synonyms of “cancer”, mainly including carcinoma, neoplasm, and tumor. Firstly, we input the Web of Science database with English Subject words= “cancer” OR “tumor” OR “carcinoma” OR “neoplasm”, and TS= “pain”, and TS= “acupuncture” OR “Acupuncture Therapy” OR “Acupuncture, Ear” OR “Acupuncture Points” OR “Acupuncture Analgesia”, 19 respectively. Next is Web of Science database settings: literature was retrieved online through the Science Citation Index-Expanded of the Web of Science Core Collection on October 25, 2020, 20 and the language of the literature is not limited.…”

Section: Methodsmentioning

confidence: 99%

Knowledge Mapping of Acupuncture for Cancer Pain: A Scientometric Analysis (2000–2019)

Huang¹,

Zhao²,

Xiang³

2021

JPR

Self Cite

View full text Add to dashboard Cite

Objective This study aimed to demonstrate the state of the present situation and trends concerning the global use of acupuncture for cancer pain in the past 20 years. Methods Searched the Web of Science database from 2000 to 2019 related to acupuncture for cancer pain, and then used CiteSpace to conduct scientometric analysis to acquire the knowledge mapping. Results Yearly output has increased year by year, and the growth rate has become faster after 2012. According to the cluster analysis of institutions, authors, cited references, and keywords, 4, 4, 15, and 14 categories were obtained, respectively. The most productive countries, institutions, and authors are the USA, Mem Sloan Kettering Cancer Center, and Mao JJ, whose frequencies are 196, 24, and 17, respectively. However, the most important of them are Australia, Univ. Maryland, and Bao T, owing to their highest centrality, they are 0.90, 0.21, and 0.09 separately. Moreover, cited references that contributed to the most co-citations are Crew KD (2010), however, the most key cited reference is Roscoe JA (2003). Keywords such as acupuncture, pain, breast cancer, palliative care, and quality of life are the most frequently used. But auricular acupuncture is the crucial keyword. In the cluster analysis of institutions, authors, cited references, and keywords, the more convincing research categories are multiple myeloma, placebo effect, neck malignancies, and early breast cancer, with S values of 0.990, 0.991, 0.990, and 0.923, respectively. Therefore, they can be regarded as research hotspots in this field. Conclusion Based on the scientometric analysis in the past 20 years, the knowledge mapping of the country, institution, author, cited reference, and the keyword is gained, which has an important guiding significance for quickly and accurately positioning the trend in this field.

show abstract

“…The basic parameter settings of Citespace software were the same as those of Zhao Y. [ 6 ] On this basis, we adopted VOS viewer and Carrot software to perform cluster analysis and comparison on keywords and drew a visual map. In the network graph, different nodes represented various elements such as authors, institutions, countries, and keywords, while the size of nodes reflected the number or frequency of publications.…”

Section: Methodsmentioning

confidence: 99%

Bibliometric analysis of acute pancreatitis in Web of Science database based on CiteSpace software

et al. 2020

View full text Add to dashboard Cite

Objectives: Recent years have witnessed some controversial viewpoints in clinical and basic research, which exert a great influence on the research trend of acute pancreatitis (AP). We aimed to analyze the literature on AP by metrology, co-occurrence, co-citation, and visualization, and to explore the research status and trend in this field in the past 5 years. Methods: The relevant literature collected in Web of Science Core Collection (WoSCC) database from 2015 to 2019 was searched using “acute pancreatitis” as the title word, and the co-occurrence analysis of authors, institutions, countries, and keywords was carried out by using CiteSpace V. On this basis, the keywords were clustered and analyzed by using VOSviewer 1.6.8 and Carrot 2 software, and a visual map was drawn. Results: A total of 2035 articles were included, with an average annual volume of more than 400. The high-yield authors were mainly Chinese, among which Li WQ was the most prominent. Most of these articles were from universities and institutions of high-yielding countries including China, the United States, and India. The main sources of journals were professional journals, among which Pancreas and Pancreatology have the most literature collection volume (both over 100), including clinical and basic research. Among the funds, the National Natural Science Foundation of China and NIH were the main 2 sponsors. Disciplinary attributes involved multiple subjects such as gastroenterology, internal medicine, and surgery. Keyword co-occurrence and clustering results showed that the classification, mortality, and risk factors of AP were still more concerned, and the research trend of this disease was the molecular mechanism of the severity of AP. Conclusions: CiteSpace can be used to analyze the knowledge graph of AP, to show its development status initially and intuitively, and to provide a reference for topic content and its further development.

show abstract

Trends in conjunctivochalasis research from 1986 to 2017

Cited by 12 publications

References 60 publications

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

P38-Mediated Cellular Senescence in Conjunctivochalasis Fibroblasts

Knowledge Mapping of Acupuncture for Cancer Pain: A Scientometric Analysis (2000–2019)

Bibliometric analysis of acute pancreatitis in Web of Science database based on CiteSpace software

Contact Info

Product

Resources

About