Trends in diabetes care with special emphasis to medicinal plants: Advancement and treatment

Tripathy, Bichitrananda; Sahoo, Nityananda; Sahoo, Sudhir Kumar

doi:10.1016/j.bcab.2021.102014

Cited by 12 publications

(8 citation statements)

References 140 publications

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“…Overall, enzyme inhibitory agents are gaining in importance in the medicinal and pharmaceutical fields. Although some enzyme inhibitors are made chemically, most have unpleasant side effects [ 56 , 57 ]. We therefore need novel and effective inhibitors from natural sources, especially from plants.…”

Section: Resultsmentioning

confidence: 99%

LC-MS/HRMS Analysis, Anti-Cancer, Anti-Enzymatic and Anti-Oxidant Effects of Boerhavia diffusa Extracts: A Potential Raw Material for Functional Applications

et al. 2021

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Boerhavia diffusa is a great tropical plant and is widely used for various traditional purposes. In the present study, we examined the influence of solvents (dichloromethane, ethyl acetate, methanol and infusion (water)) on chemical composition and biological capabilities of B. diffusa. An UHPLC-HRMS method was used to determine the chemical characterization. The biological ability was examined for antioxidant, enzyme inhibitory and anti-cancer effects. To evaluate antioxidant effects, different chemical methods (ABTS, DPPH, CUPRAC, FRAP, metal chelating and phosphomolybdenum) were applied. With regard to enzyme inhibitory properties, cholinesterases, amylase, glucosidase and tyrosinase were used. The MDA-MB-231 breast cancer cell line was chosen to determine anticancer activity. Based on the UHPLC-HRMS analysis, 37 specialized metabolites were dereplicated and identified in the studied extracts. Results revealed the presence of 15 hydroxybenzoic, hydroxycinnamic, acylquinic acids, and their glycosides, one rotenoid, seven flavonoids, 12 fatty acids and two other glycosides. Among the tested extracts, the methanol extract showed a stronger antioxidant ability compared with other extracts. The methanol extract also showed the best inhibitory effects on tyrosinase and glucosidase. In the anti-cancer evaluation, the methanol extract showed stronger anticancer effects compared with water extract. In summary, our observations can contribute to the establishment of B. diffusa as a potential candidate for functional applications in the preparation.

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Section: Resultsmentioning

confidence: 99%

LC-MS/HRMS Analysis, Anti-Cancer, Anti-Enzymatic and Anti-Oxidant Effects of Boerhavia diffusa Extracts: A Potential Raw Material for Functional Applications

et al. 2021

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“…Nowadays, diabetes has become the most frequent endocrine illness. It is considered a metabolic disorder characterized by an imbalance of carbohydrate and lipid metabolism, giving rise to high glucose levels (Tripathy et al, 2021). Diabetes incidence is continuously growing, and synthetic antidiabetic drugs are the most widely used therapeutic intervention to treat the disease.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Fig “Ficus carica L.” and its by-products: A decade evidence of their health-promoting benefits towards the development of novel food formulations

Ayuso

Carpena

Taofiq

et al. 2022

Trends in Food Science & Technology

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“…In this context, medicinal plants have a well-established record of circumventing the problems mentioned about the conventional use of drugs [ 73 ]. Medicinal compounds derived from plants could provide new, straightforward approaches to preventing and treating T2DM and its complications [ 74 , 75 , 76 ]. Traditional knowledge and practices have enabled the development of most modern medicines [ 73 , 77 ].…”

Section: Introductionmentioning

confidence: 99%

Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential

Lahlou,

Carvalho,

Pereira

et al. 2024

Pharmaceutics

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The Serra da Estrela Natural Park (NPSE) in Portugal stands out as a well-preserved region abundant in medicinal plants, particularly known for their pharmaceutical applications in diabetes prevention and treatment. This comprehensive review explores these plants’ botanical diversity, traditional uses, pharmacological applications, and chemical composition. The NPSE boast a rich diversity with 138 medicinal plants across 55 families identified as traditionally and pharmacologically used against diabetes globally. Notably, the Asteraceae and Lamiaceae families are prevalent in antidiabetic applications. In vitro studies have revealed their significant inhibition of carbohydrate-metabolizing enzymes, and certain plant co-products regulate genes involved in carbohydrate metabolism and insulin secretion. In vivo trials have demonstrated antidiabetic effects, including glycaemia regulation, insulin secretion, antioxidant activity, and lipid profile modulation. Medicinal plants in NPSE exhibit various activities beyond antidiabetic, such as antioxidant, anti-inflammatory, antibacterial, anti-cancer, and more. Chemical analyses have identified over fifty compounds like phenolic acids, flavonoids, terpenoids, and polysaccharides responsible for their efficacy against diabetes. These findings underscore the potential of NPSE medicinal plants as antidiabetic candidates, urging further research to develop effective plant-based antidiabetic drugs, beverages, and supplements.

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Trends in diabetes care with special emphasis to medicinal plants: Advancement and treatment

Cited by 12 publications

References 140 publications

LC-MS/HRMS Analysis, Anti-Cancer, Anti-Enzymatic and Anti-Oxidant Effects of Boerhavia diffusa Extracts: A Potential Raw Material for Functional Applications

LC-MS/HRMS Analysis, Anti-Cancer, Anti-Enzymatic and Anti-Oxidant Effects of Boerhavia diffusa Extracts: A Potential Raw Material for Functional Applications

Fig “Ficus carica L.” and its by-products: A decade evidence of their health-promoting benefits towards the development of novel food formulations

Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential

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