Trends in Diabetes Prevalence Among American Indian and Alaska Native Children, Adolescents, and Young Adults

Acton, Kelly J.; Burrows, Nilka Ríos; Moore, Kelly; Querec, Linda J.; Geiss, Linda S.; Engelgau, Michael M.

doi:10.2105/ajph.92.9.1485

Cited by 164 publications

(122 citation statements)

References 33 publications

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“…The prevalence of type 2 diabetes in this population was also similar to other reports of American-Indian women of childbearing age (28). In the present study, consistent with many studies, both age and obesity were strongly associated with diabetes (19).…”

Section: Resultssupporting

confidence: 92%

Hepatitis C Infection and Type 2 Diabetes in American-Indian Women

Wilson

2004

Diabetes Care

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OBJECTIVE -The aim of this study was to describe the association between hepatitis C virus (HCV) infection and type 2 diabetes among a group of American-Indian women who were screened for both conditions. RESEARCH DESIGN AND METHODS -The study population was a convenience sample of women who were receiving prenatal care. All women were systematically screened for both HCV and diabetes.RESULTS -A total of 426 women were included in the sample. HCV infection was detected in 13 (3.1% [95% CI 1.7-5.0]) and type 2 diabetes in 22 (5.2%, [3.3-7.6]) women. Women diagnosed with type 2 diabetes were more obese and had higher serum alanine aminotransferase activity compared with women without diabetes. Four of 13 (30.8% [10.6 -58.7]) HCV-infected women and 18 of 413 (4.4% [2.7-6.7]) women without evidence of HCV infection had type 2 diabetes. (odds ratio 9.8 [95% CI 2.4 -34.0], Fisher's exact test P ϭ 0.003). In a logistic regression model, increasing age (10-year increments), obesity (by standard deviations from the mean BMI), and positive HCV status were each independently related to the diagnosis of diabetes.CONCLUSIONS -Among American-Indian women, type 2 diabetes is more common in those with than in those without HCV infection. This association and its potential mechanisms may have clinical implications. Investigation into the mechanisms linking HCV infection to the expression of type 2 diabetes may also help to define processes that promote the development of type 2 diabetes in susceptible individuals.

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Section: Resultssupporting

confidence: 92%

Hepatitis C Infection and Type 2 Diabetes in American-Indian Women

Wilson

2004

Diabetes Care

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“…The prevalence of diagnosed diabetes among American Indians aged 15-19 years, as reported right across the Indian Health Service, increased from 0.32 to 0.54% from 1990 to 1998 (30). Although the prevalence of type 2 diabetes was higher among females, the relative increase over this time period was greater among males (0.23 to 0.41% for males vs. 0.42 to 0.68% for females).…”

Section: Population-based Studiesmentioning

confidence: 81%

Type 2 Diabetes in the Young: The Evolving Epidemic

Alberti

Zimmet

Shaw³

et al. 2004

Diabetes Care

412

251

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“…68,69 AI/AN in all regions have a higher prevalence of obesity than NHW and AI/AN have an elevated prevalence of diabetes. 56,70,71 It is likely that NASH plays a significant role in the development of HCC in AI/AN.…”

Section: Discussionmentioning

confidence: 99%