Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006~2011)

Dobly, Alexandre; Heyden, Sara Van der; Roels, Stefan

doi:10.4142/jvs.2013.14.1.45

Cited by 16 publications

(14 citation statements)

References 38 publications

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“…The frequencies of the Comparing our data with observations in other European countries during the past decade was noted that, the more common allele in Belgium (79.3%) and in Great Britain (52.3%) was ARR (Dobly et al, 2013;OrtizPelaez et al, 2014); these values are quite higher than the ARR frequency observed in this study, probably due to the effect of different European Genetic Selection Plans against this disease. The highest two genotypic frequencies were ARR/ARQ and ARQ/ARQ ( Figure 3); the observed values were comparable to that reported by Vaccari et al (2009) in the Sarda breed and to the ones reported by Pongolini et al (2009) in other Italian breeds (Appenninica, Comisana and Sarda breeds).…”

Section: Resultscontrasting

confidence: 55%

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Biodiversity and Genetic Polymorphisms Against Scrapie inSopravissanaSheep Breed

Curcio

Lasagna

Sarti

et al. 2015

Italian Journal of Animal Science

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Scrapie is a neurodegenerative disease affecting ovine and it is one of several transmissible spongiform encephalopathies (TSEs). Scrapie is recognized as two forms -classical and atypical. Susceptibility or resistance to classical scrapie is strongly regulated by the polymorphisms at codons 136, 154 and 171 of the PRNP gene. Genetic role in atypical scrapie has been described at codons 141 and 154, these ones are involved in the occurrence of the disease at different risk degrees. The aim of this study was to assess the allelic and genotypic frequencies in Sopravissana breed, an endangered autochthon breed of central Italy; in addition, the presence and the frequency of potential protective ARQ allele variants able to increase scrapie resistance by preserving a higher variability of PRNP were evaluated. Three alleles (ARQ, ARR and AHQ) and seven genotypes were observed based on codons 136, 154 and 171 with different frequencies. Moreover, the entire coding sequence of prion protein (PRNP) of the ARQ/ARQ was sequenced; two non-synonymous L141F (23.8%) and H143R (16.7%), also two synonymous polymorphisms (codons 231 and 237) were found. The results showed that the ARQ/ARQ sheep should be considered as a genetic class, which may potentially include animals with different scrapie susceptibility because of the presence of additional polymorphisms. This may allow the application of alternative strategies for breeding programmes in this endangered breed.

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Section: Resultscontrasting

confidence: 55%

“…The ARR/ARQ genotype was the most frequent also in British sheep population (29.5%) (Baylis et al, 2004). A Belgian sheep population resulted to have ARR/ARR as dominant genotype (Dobly et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Biodiversity and Genetic Polymorphisms Against Scrapie inSopravissanaSheep Breed

Curcio

Lasagna

Sarti

et al. 2015

Italian Journal of Animal Science

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“…The frequency of these genotypes, as well as of all the genotypes belonging to Risk Groups 3,4 and 5, could be significantly decreased as a result of the implementation of selective breeding programs, resulting in lower incidence of classical scrapie in the future. Experience with the successful implementation of selective breeding programs in the European countries (UK, France, Cyprus, the Netherlands, Belgium) has shown an impressive reduction in the incidence of the disease (Dawson et al,2008, Palhiere et al,2008, Hagenaars et al,2010, Nodelijk et al,2011, Ortiz-Pelaez and Bianchini,2011, Dobly et al,2013. For example, 3,063 classical scrapie cases in sheep were reported in Cyprus in the period 2002-2015.…”

Section: Discussionmentioning

confidence: 99%

“…The five most common haplotypes are ARR, ARQ, AHQ, ARH and VRQ (Baylis et al, 2004, Dobly et al,2013. Additional haplotypes (TRQ, ARK, VRR, AHR, VHQ and TRR) have been reported so far (Kutzer et al,2002, De Silva et al,2003, Acutis et al,2004, Billinis et al,2004, F. Guan et al,2011, Psifidi et al,2011, Oner et al,2011, Alvarez et al,2011, Zhao et al,2012, Meydan et al,2012, Granato et al,2013.…”

Section: Introductionmentioning

confidence: 96%

Prion protein gene polymorphisms in classical scrapie-affected flocks of sheep in Central Macedonia

Kioutsioukis

Papadogiannakis

Palaska

et al. 2018

J Hellenic Vet Med Soc

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Research articlesheep, 340 were of Chios breed, 633 Chios crossbred and 483 crossbred. The examined sheep showed high genotype variability, as a total of 7 haplotypes and 23 different genotypes were found. The predominant allele and the predominant genotype were ARQ and ARQ/ARQ respectively, in all breeds studied, followed by the ARR allele and the ARR/ ARQ genotype. The TRQ allele was frequent in Chios and Chios crossbred, while the VRQ allele was rare for all the breeds. Interestingly, 3 genotypes (ARH/TRQ, ARR/ARK and ARK/VRQ) were detected for the first time in Greece and two of them (ARH/TRQ and ARK/VRQ) have, to our knowledge, never been previously reported. Furthermore, it is emphasized that our country outnumbers all European countries in classical scrapie cases of sheep every year.Therefore, there is an urgent need to reduce the incidence of classical scrapie through the implementation of selective breeding programs. This is supported by the fact that the prevalence of classical scrapie in the Greek sheep population is highly associated with the predominant genotype ARQ/ARQ. Therefore, the elimination of the ARQ/ARQ and the other susceptible genotypes (belonging to Risk Groups 3 and 5, according to the National Scrapie Plan of Great Britain) would reduce dramatically the incidence of classical scrapie in Greece. αλληλόμορφα και 23 διαφορετικοί γονότυποι. Ο κυρίαρχος γονότυπος σε όλες τις φυλές ήταν ο ARQ/ARQ, ακολουθούμενος από τον ARR/ARQ. Ο απλότυπος TRQ ήταν συχνός στα Χιώτικα και στα ημίαιμα Χίου πρόβατα, ενώ ο απλότυπος VRQ ήταν σπάνιος σε όλες τις φυλές. Είναι αξιοσημείωτο ότι 3 γονότυποι (ARH/TRQ, ARR/ARK και ARK/VRQ) ανιχνεύθηκαν για πρώτη φορά στην Ελλάδα. Επιπλέον, 2 από αυτούς τους γονότυπους (ARH/TRQ, και ARK/VRQ) δεν έχουν, καθ' όσον γνωρίζουμε, αναφερθεί ποτέ μέχρι σήμερα. Επίσης, δίνεται έμφαση στο γεγονός ότι στη χώρα μας παρατηρούνται τα περισσότερα κρούσματα κλασσικής τρομώδους νόσου των προβάτων κάθε χρόνο σε όλη την Ευρώπη. Συνεπώς είναι επιτακτική ανάγκη να μειωθεί η επίπτωση της νόσου στην Ελλάδα, μέσω της εφαρμογής προγραμμάτων επιλογής/αναπαραγωγής ανθεκτικών προβάτων (selective breeding programs) ως προς την κλασσική τρομώδη νόσο. Σε αυτό συνηγορεί το γεγονός ότι ο επιπολασμός της νόσου στην Ελλάδα συνδέεται με τον γονότυπο ARQ/ARQ, ο οποίος είναι ο πιο συχνός γονότυπος. Άρα η δραστική μείωση του ARQ/ARQ και άλλων ευαίσθητων γονότυπων θα προκαλέσει δραματική μείωση της επίπτωσης της νόσου, προς όφελος της προβατοτροφίας και της εθνικής μας οικονομίας. .Λέξεις-Κλειδιά: τρομώδης νόσος, γονοτυπική ανάλυση, πρωτεϊνη prion, αλυσιδωτή αντίδραση πολυμεράσης

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“…Based on the positive experience of these pioneer states, the European Commission first . Successful results of selective breeding programmes in sheep were reported in many studies (Hagenaars et al, 2010;Nodelijk et al, 2011;Dobly et al, 2013;Ortiz-Pelaez et al, 2014). To achieve scrapie-free status, as described by the World Organization for Animal Health (OIE), in the United States has been similarly applied the National Scrapie Surveillance Plan.…”

Section: Introductionmentioning

confidence: 99%

Review: A review on classical and atypical scrapie in caprine: Prion protein gene polymorphisms and their role in the disease

Curcio

Sebastiani

Lorenzo

et al. 2016

Animal

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Scrapie is a naturally occurring transmissible spongiform encephalopathy in sheep and goat. It has been known for~250 years and is characterised by the accumulation of an abnormal isoform of a host-encoded prion protein that leads to progressive neurodegeneration and death. Scrapie is recognised in two forms, classical and atypical scrapie. The susceptibility to both types of scrapie is influenced by polymorphisms of the prion protein gene (PRNP). Sheep susceptibility or resistance to classical scrapie is strongly regulated by the polymorphisms at codons 136, 154 and 171 of the PRNP. The genetic role in atypical scrapie in sheep has been defined by polymorphisms at codons 141, 154 and 171, which are associated with different degrees of risk in the occurrence of the ovine disease. Progress has been achieved in the prevention of scrapie in sheep due to efficient genetic breeding programmes based on eradication and control of the disease. In Europe, the success of these programmes has been verified by applying eradication and genetic selection plans. In general terms, the ovine selection plans aim to eliminate and reduce the susceptible allele and to enrich the resistant allele ARR. During outbreaks all susceptible animals are slaughtered, only ARR/ARR resistant rams and sheep and semi-resistant females are preserved. In the occurrence of scrapie positive goats a complete cull of the flock (stamping out) is performed with great economic loss and severe risk of extinction for the endangered breeds. The ability to select scrapie-resistant animals allows to define new breeding strategies aimed to boost genetic progress while reducing costs during scrapie outbreaks. Allelic variants of PRNP can be protective for caprine scrapie, and the knowledge of their distribution in goats has become very important. Over the past few years, the integration of genetic information on goat populations could be used to make selection decisions, commonly referred to as genetic selection. The objective of this review was to summarise the main findings of polymorphisms of the caprine prion protein (PrP) gene and to discuss the possible application of goat breeding schemes integrating genetic selection, with their relative advantages and limitations.

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Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006~2011)

Cited by 16 publications

References 38 publications

Biodiversity and Genetic Polymorphisms Against Scrapie inSopravissanaSheep Breed

Biodiversity and Genetic Polymorphisms Against Scrapie inSopravissanaSheep Breed

Prion protein gene polymorphisms in classical scrapie-affected flocks of sheep in Central Macedonia

Review: A review on classical and atypical scrapie in caprine: Prion protein gene polymorphisms and their role in the disease

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